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  4. PVRIG (TGI-2 Biosimilar) Recombinant Monoclonal Antibody

PVRIG (TGI-2 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA721905MB4HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    PVRIG (TGI-2 Biosimilar Antibody)重組單克隆抗體是一種用于科研領(lǐng)域的生物制劑。該產(chǎn)品作為重組單克隆抗體，具有高度的特異性和靶向性，為相關(guān)研究提供了可靠的工具。 在科研應(yīng)用中，PVRIG 重組單克隆抗體可用于探究其與特定靶點(diǎn)的相互作用機(jī)制，助力研究人員深入了解相關(guān)生理和病理過(guò)程。通過(guò)特異性結(jié)合目標(biāo)分子，為疾病的基礎(chǔ)研究、藥物開發(fā)的前期探索等提供重要支持。 該抗體采用重組技術(shù)制備，能夠保證批次間的穩(wěn)定性和一致性，有利于提高實(shí)驗(yàn)結(jié)果的可靠性和可重復(fù)性。研究人員可利用其開展細(xì)胞水平和分子水平的實(shí)驗(yàn)，為揭示疾病發(fā)生發(fā)展的分子機(jī)制、篩選潛在治療靶點(diǎn)等研究方向提供有力的實(shí)驗(yàn)材料。 作為科研用試劑，PVRIG 重組單克隆抗體為生命科學(xué)領(lǐng)域的研究工作者提供了一個(gè)重要的研究工具，有助于推動(dòng)相關(guān)領(lǐng)域的科學(xué)研究進(jìn)展，為后續(xù)的臨床轉(zhuǎn)化研究奠定基礎(chǔ)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    NM1F research-grade biosimilar; NM 1F research-grade biosimilar; NM-1F research-grade biosimilar; TGI 2 research-grade biosimilar; TGI-2/NM1F research-grade biosimilar ;PVRIG antibody; C7orf15 antibody; Transmembrane protein PVRIG antibody; CD112 receptor antibody; CD112R antibody; Poliovirus receptor-related immunoglobulin domain-containing protein antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human PVRIG protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
  • 基因功能參考文獻(xiàn)：
    1. Blockade of TIGIT or CD112R, separately or together, enhances trastuzumab-triggered antitumor response by human NK cells. PMID: 28623459
    2. Describe CD112R, a member of poliovirus receptor-like proteins, as a new coinhibitory receptor for T cells. CD112R is preferentially expressed on T cells and inhibits T cell receptor-mediated signals. PMID: 26755705
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 組織特異性：
    Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 32190

    OMIM: 617012

    KEGG: hsa:79037

    STRING: 9606.ENSP00000316675

    UniGene: Hs.729356



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