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  4. PVRIG (JS-009 Biosimilar) Recombinant Monoclonal Antibody

PVRIG (JS-009 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA721905MB3HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    PVRIG (JS-009 Biosimilar Antibody)重組單克隆抗體是一種針對特定靶點設計的生物治療研究工具，主要應用于免疫學、腫瘤學等領域的基礎研究與機制探索。該抗體通過基因工程技術制備，具有高特異性和親和力，能夠精準識別并結合靶標蛋白，為研究其生物學功能及相關信號通路提供有力支持。 作為科研用重組抗體，PVRIG (JS-009) 在實驗中可用于蛋白質(zhì)檢測、細胞功能分析、動物模型構建等多個環(huán)節(jié)。其重組表達工藝確保了批次間的穩(wěn)定性和一致性，有助于提升實驗結果的可靠性與可重復性。研究人員可利用該抗體深入探究靶標分子在免疫調(diào)節(jié)、腫瘤微環(huán)境調(diào)控等過程中的作用機制，為開發(fā)新型治療策略提供理論依據(jù)。 該產(chǎn)品僅用于科研用途，不適用于臨床診斷或治療。在使用過程中，需嚴格遵循實驗室操作規(guī)范，根據(jù)具體研究需求選擇合適的應用方法，如等。通過結合先進的實驗技術，PVRIG (JS-009 Biosimilar Antibody)重組單克隆抗體能夠幫助科研人員揭示疾病發(fā)生發(fā)展的分子機制，推動生命科學領域的創(chuàng)新研究。
  • Uniprot No.：
  • 基因名：
  • 別名：
    JS-009 research-grade biosimilar; TAB009 research-grade biosimilar; TAB009/JS009 research-grade biosimilar ;PVRIG antibody; C7orf15 antibody; Transmembrane protein PVRIG antibody; CD112 receptor antibody; CD112R antibody; Poliovirus receptor-related immunoglobulin domain-containing protein antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human PVRIG protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
  • 基因功能參考文獻：
    1. Blockade of TIGIT or CD112R, separately or together, enhances trastuzumab-triggered antitumor response by human NK cells. PMID: 28623459
    2. Describe CD112R, a member of poliovirus receptor-like proteins, as a new coinhibitory receptor for T cells. CD112R is preferentially expressed on T cells and inhibits T cell receptor-mediated signals. PMID: 26755705
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 組織特異性：
    Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-
  • 數(shù)據(jù)庫鏈接：

    HGNC: 32190

    OMIM: 617012

    KEGG: hsa:79037

    STRING: 9606.ENSP00000316675

    UniGene: Hs.729356



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