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  4. PVRIG (GSK-4381562 Biosimilar) Recombinant Monoclonal Antibody

PVRIG (GSK-4381562 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA721905MB2HU
  • 規(guī)格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    PVRIG (GSK-4381562 Biosimilar Antibody)重組單克隆抗體是一種用于科研領域的生物試劑，專為研究程序性死亡受體1（PD-1）通路相關免疫調節(jié)機制而開發(fā)。該抗體通過基因工程技術制備，具有高度的靶向特異性，能夠精準識別并結合PVRIG（脊髓灰質炎病毒受體相關免疫球蛋白結構域蛋白），從而為探索腫瘤微環(huán)境中的免疫抑制通路提供關鍵工具。 作為研究用試劑，該抗體可應用于多種實驗場景，包括但不限于細胞水平的受體結合分析、共定位、檢測以及體外功能性實驗等。其重組表達工藝確保了批次間的穩(wěn)定性和高純度，有助于提升實驗結果的可靠性與可重復性。研究人員可借助該抗體深入探究PVRIG與PVRL2等配體的相互作用機制，以及其在腫瘤免疫逃逸中的調控作用，為開發(fā)新型免疫治療策略提供理論依據。 該產品嚴格用于科研用途，不適用于臨床診斷或治療。在使用過程中，建議根據具體實驗需求優(yōu)化抗體濃度和孵育條件，以獲得最佳檢測效果。通過特異性阻斷PVRIG信號通路，該抗體有望助力揭示免疫檢查點分子的協(xié)同調控網絡，為腫瘤免疫學及相關領域的基礎研究和藥物開發(fā)提供重要支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    GSK4381562 research-grade biosimilar; GSK 4381562 research-grade biosimilar; GSK4381562A research-grade biosimilar; GSK562 research-grade biosimilar; SRF813 research-grade biosimilar; SRF-813 research-grade biosimilar ;PVRIG antibody; C7orf15 antibody; Transmembrane protein PVRIG antibody; CD112 receptor antibody; CD112R antibody; Poliovirus receptor-related immunoglobulin domain-containing protein antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human PVRIG protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
  • 基因功能參考文獻：
    1. Blockade of TIGIT or CD112R, separately or together, enhances trastuzumab-triggered antitumor response by human NK cells. PMID: 28623459
    2. Describe CD112R, a member of poliovirus receptor-like proteins, as a new coinhibitory receptor for T cells. CD112R is preferentially expressed on T cells and inhibits T cell receptor-mediated signals. PMID: 26755705
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 組織特異性：
    Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-
  • 數據庫鏈接：

    HGNC: 32190

    OMIM: 617012

    KEGG: hsa:79037

    STRING: 9606.ENSP00000316675

    UniGene: Hs.729356



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