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  4. PVRIG (COM-701 Biosimilar) Recombinant Monoclonal Antibody

PVRIG (COM-701 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA721905MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    PVRIG (COM-701 Biosimilar) Recombinant Monoclonal Antibody是一種用于科研領(lǐng)域的重組單克隆抗體。作為重組抗體，它通過基因工程技術(shù)在體外表達和制備，具有高度的特異性和均一性，能夠精準識別并結(jié)合其靶標分子，為相關(guān)研究提供可靠的工具。 在科研應用中，該抗體可廣泛用于生物醫(yī)學研究的多個方面。例如，在細胞生物學研究中，可用于檢測特定靶蛋白的表達水平、亞細胞定位及相互作用；在分子生物學實驗中，可作為探針用于蛋白質(zhì)純化等技術(shù)；同時，在疾病機制研究領(lǐng)域，也能助力探索相關(guān)信號通路的調(diào)控機制，為深入理解生理和病理過程提供支持。 該重組單克隆抗體憑借其明確的分子結(jié)構(gòu)和可重復性，有助于提高實驗結(jié)果的準確性和可靠性，是生命科學研究中不可或缺的重要試劑，能夠滿足科研人員在基礎研究、藥物靶點發(fā)現(xiàn)等方面的實驗需求。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CGEN-15029 research-grade biosimilar; COM 701 research-grade biosimilar; COM701/PVRIG research-grade biosimilar ;PVRIG antibody; C7orf15 antibody; Transmembrane protein PVRIG antibody; CD112 receptor antibody; CD112R antibody; Poliovirus receptor-related immunoglobulin domain-containing protein antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human PVRIG protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
  • 基因功能參考文獻：
    1. Blockade of TIGIT or CD112R, separately or together, enhances trastuzumab-triggered antitumor response by human NK cells. PMID: 28623459
    2. Describe CD112R, a member of poliovirus receptor-like proteins, as a new coinhibitory receptor for T cells. CD112R is preferentially expressed on T cells and inhibits T cell receptor-mediated signals. PMID: 26755705
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 組織特異性：
    Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-
  • 數(shù)據(jù)庫鏈接：

    HGNC: 32190

    OMIM: 617012

    KEGG: hsa:79037

    STRING: 9606.ENSP00000316675

    UniGene: Hs.729356



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