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  4. PTPRS (KK-4277 Biosimilar) Recombinant Monoclonal Antibody

PTPRS (KK-4277 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA613393MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    PTPRS (KK-4277 Biosimilar Antibody)重組單克隆抗體是一種針對(duì)蛋白質(zhì)酪氨酸磷酸酶受體S（PTPRS）的高特異性生物制劑，主要應(yīng)用于生命科學(xué)研究領(lǐng)域。該抗體通過重組DNA技術(shù)在哺乳動(dòng)物細(xì)胞表達(dá)系統(tǒng)中制備，具有高度均一性和批次穩(wěn)定性，可作為關(guān)鍵工具用于PTPRS相關(guān)的分子機(jī)制研究、信號(hào)通路分析及藥物靶點(diǎn)驗(yàn)證等科研場(chǎng)景。 PTPRS作為跨膜型酪氨酸磷酸酶家族成員，在細(xì)胞黏附、遷移、增殖及神經(jīng)發(fā)育等生理過程中發(fā)揮重要調(diào)控作用。本產(chǎn)品通過特異性識(shí)別PTPRS胞外結(jié)構(gòu)域，能夠高效結(jié)合靶蛋白并阻斷其磷酸酶活性，及某些實(shí)驗(yàn)技術(shù)。其高親和力特性（KD值<1 nM）確保在低濃度條件下即可實(shí)現(xiàn)精準(zhǔn)檢測(cè)與功能干預(yù)，適用于原代細(xì)胞、細(xì)胞系及組織樣本的研究。 該抗體經(jīng)過嚴(yán)格的質(zhì)量控制，包括純度分析（SDS-PAGE檢測(cè)純度>95%）、內(nèi)毒素檢測(cè)（<0.1 EU/μg）及活性驗(yàn)證（通過體外磷酸酶抑制實(shí)驗(yàn)確認(rèn)生物學(xué)功能），可滿足不同實(shí)驗(yàn)體系的需求。此外，產(chǎn)品提供凍干粉劑型，經(jīng)優(yōu)化緩沖液配方處理，復(fù)溶后在-20℃條件下可穩(wěn)定保存12個(gè)月以上，有效保障實(shí)驗(yàn)結(jié)果的重復(fù)性與可靠性。 作為科研用工具試劑，PTPRS (KK-4277 Biosimilar Antibody)重組單克隆抗體為探索PTPRS在腫瘤發(fā)生、神經(jīng)退行性疾病及免疫調(diào)節(jié)中的作用機(jī)制提供了有力支持，助力科研人員在細(xì)胞生物學(xué)、分子醫(yī)學(xué)等領(lǐng)域取得突破性進(jìn)展。
  • Uniprot No.：
  • 基因名：
  • 別名：
    KK4277 research-grade biosimilar; KK 4277 research-grade biosimilar ;PTPRS antibody; Receptor-type tyrosine-protein phosphatase S antibody; R-PTP-S antibody; EC 3.1.3.48 antibody; Receptor-type tyrosine-protein phosphatase sigma antibody; R-PTP-sigma antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human PTPRS protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycan. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase. Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3. Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta.
  • 基因功能參考文獻(xiàn)：
    1. Study identified several CpG sites and specifically several CpGs in the PTPRS and PER3 genes differentially methylated between obese and non-obese children, suggesting a role for DNA methylation concerning development of childhood obesity. PMID: 28614626
    2. interaction of receptor type of protein tyrosine phosphatase sigma (RPTPsigma) with a glycosaminoglycan library PMID: 29420785
    3. Receptor protein tyrosine phosphatase sigma (RPTPsigma) regulates neuronal extension and acts as a presynaptic nexus for multiple protein and proteoglycan interactions during synaptogenesis. PMID: 25385546
    4. Data demonstrate that synoviocytes are regulated by an RPTPsigma-dependent proteoglycan switch in vivo, which can be targeted for rheumatoid arthritis therapy. PMID: 25995222
    5. represents an evolutionarily conserved pDC-specific inhibitory receptor, and is required to prevent spontaneous IFN production and immune-mediated intestinal inflammation PMID: 26231120
    6. crystallographic analyses of a shared HSPG-CSPG binding site reveal a conformational plasticity that can accommodate diverse glycosaminoglycans with comparable affinities; HS and analogs induced RPTPsigma ectodomain oligomerization which was inhibited by CS PMID: 21454754
    7. Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma. PMID: 22027896
    8. Intragenic microdeletions of the EGFR phosphatase PTPRS were found frequently (26%) in head and neck cancers, identifying this gene as a target of 19p13 loss. PMID: 22065749
    9. Transgenic zebrafish carrying a promoter-driven expression vector reveal the increased density of olfactory sensory neuron-specific cell synapses. PMID: 21812780
    10. Data show that PTPsigma localizes to PtdIns3P-positive membranes in cells, and this vesicular localization is enhanced during autophagy. PMID: 21303930
    11. The receptor protein tyrosine phosphatase sigma (RPTPsigma) has now been identified as a receptor for inhibitory chondroitin sulfate proteoglycans. PMID: 20179269
    12. Transient overexpression of the short splice variant 3 of RPTPR Sigma conferred alpha-LTX induced secretion to hamster insulinoma (HIT-15) cells. In contrast, the long splice variant 2 was inactive in secretion or in a single cell assay. PMID: 16552719
    13. Three SNPs that flank exon 8 are associated with ulcerative colitis. The presence of these SNPs is associated with novel splicing that removes the third immunoglobulin-like domain (exon 9) from the extracellular portion of PTPsigma. PMID: 17614280
    14. SNPs rs1143699, rs4807015, and rs1978237 confer an increased risk of developing type 2 diabetes mellitus. PMID: 17893260
    15. In colorectal tumors, microsatellite repeats mutation rates are higher than the mean mutation frequency PMID: 19000305

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Perikaryon. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic density. Cell projection, neuron projection. Cell projection, growth cone.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Receptor class 2A subfamily
  • 組織特異性：
    Detected in peripheral blood plasmacytoid dendritic cells (at protein level). Detected in all tissues tested except for placenta and liver. Detected in peripheral blood plasmacytoid dendritic cells.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 9681

    OMIM: 601576

    KEGG: hsa:5802

    STRING: 9606.ENSP00000349932

    UniGene: Hs.744928



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