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  4. OSMR (Vixarelimab Biosimilar) Recombinant Monoclonal Antibody

OSMR (Vixarelimab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA857869MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    OSMR (Vixarelimab Biosimilar Antibody)重組單克隆抗體是一種用于科研領(lǐng)域的生物制劑。該抗體通過(guò)重組DNA技術(shù)制備，具有高度的靶向性和特異性。 在結(jié)構(gòu)上，該抗體由兩條重鏈和兩條輕鏈組成，通過(guò)二硫鍵連接形成典型的Y型結(jié)構(gòu)。其可變區(qū)能夠特異性識(shí)別并結(jié)合靶分子，展現(xiàn)出優(yōu)異的結(jié)合親和力。 作為科研工具，該抗體可廣泛應(yīng)用于多種研究場(chǎng)景。它可用于蛋白質(zhì)印跡某些實(shí)驗(yàn)，助力研究人員深入探索相關(guān)分子機(jī)制和信號(hào)通路。 在細(xì)胞水平研究中，該抗體能夠特異性識(shí)別目標(biāo)抗原，為研究細(xì)胞表面受體表達(dá)、細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)等提供有力支持。同時(shí)，它也可用于相關(guān)疾病模型的構(gòu)建與研究，為疾病機(jī)制探討和潛在治療策略開(kāi)發(fā)提供實(shí)驗(yàn)基礎(chǔ)。 該抗體的制備過(guò)程嚴(yán)格遵循生物制劑生產(chǎn)標(biāo)準(zhǔn)，確保了產(chǎn)品的高純度和批次間的穩(wěn)定性，為科研實(shí)驗(yàn)的可重復(fù)性和可靠性提供保障。研究人員可根據(jù)具體實(shí)驗(yàn)需求，選擇合適的應(yīng)用方式和濃度，以獲得準(zhǔn)確的實(shí)驗(yàn)結(jié)果。 總之，OSMR (Vixarelimab Biosimilar Antibody)重組單克隆抗體作為一種重要的科研工具，為生命科學(xué)領(lǐng)域的研究工作提供了有力支持，有助于推動(dòng)相關(guān)領(lǐng)域的科學(xué)探索和創(chuàng)新發(fā)現(xiàn)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Immunoglobulin g (234-proline,303-glutamine), anti-(human oncostatin m receptor subunit .beta.) (human monoclonal kpl-716 .gamma.-chain), disulfide with human monoclonal kpl-716 .lambda.-chain, dimer research-grade biosimilar; KPL 716 research-grade biosimilar; KPL-716 research-grade biosimilar; RG6536 research-grade biosimilar ;OSMR antibody; OSMRB antibody; Oncostatin-M-specific receptor subunit beta antibody; Interleukin-31 receptor subunit beta antibody; IL-31 receptor subunit beta antibody; IL-31R subunit beta antibody; IL-31R-beta antibody; IL-31RB antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human OSMR protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.
  • 基因功能參考文獻(xiàn)：
    1. Polymorphisms of the OSMR rs2292016 locus are related to the development and outcome of DCM. PMID: 29652994
    2. Missense mutatios were found in exon 10 of the oncostatin-M specific receptor beta subunit (OSMR) gene in all of the six patients from family 1, and in exon 14 of the OSMR gene in all of the four patients from family 2. PMID: 29419851
    3. The PLAC1 expression has been demonstrated for the first time in cervical cancers. This preliminary study has further revealed a complex relationship between PLAC1 expression, cervical cancer histologic type, p53, and HPV type that requires further investigation. PMID: 28375929
    4. OSMR-beta deficiency in macrophages improved high-fat diet-induced atherogenesis and plaque vulnerability PMID: 28258089
    5. OSM and OSMR are highly expressed in inflammatory bowel disease intestinal mucosa compared to control mucosa. Intestinal stromal cells express abundant OSMR. PMID: 28368383
    6. OSM:OSMR interactions are able to induce EMT, increased cancer stem cell-like properties and enhanced lung colonisation in SCC cells PMID: 27351213
    7. the RET p.S891A mutation combined with OSMR p.G513D may underlie a novel phenotype manifesting as familial medullary thyroid carcinoma and cutaneous amyloidosis PMID: 26356818
    8. this study offers new findings on the molecular genetics and disease relevance of mutations in OSMR in Familial primary localized cutaneous amyloidosis. PMID: 25792357
    9. Oncostatin M and interleukin-31: Cytokines, receptors, signal transduction and physiology. PMID: 26198770
    10. OSMRBeta in neurons is critical for neuronal survival during cerebral ischemic/reperfusion. PMID: 26311783
    11. primary localized cutaneous amyloidosis has a missense mutation in oncostatin M receptor beta PMID: 25054142
    12. The interleukin IL-31/IL-31receptor axis contributes to tumor growth in human follicular lymphoma. PMID: 25283844
    13. oncostatin M is a cytokine possessing vigorous antiviral and immunostimulatory properties which is released by APC upon interaction with CD40L present on activated CD4+ T cells. PMID: 24418171
    14. The disease severity of rheumatoid arthritis and systemic lupus erythematosus can be partially affected by the OSMR promoter polymorphisms. PMID: 24219225
    15. We conclude that an OSMR/TGM2/integrin-alpha5beta1/fibronectin pathway is of biological significance in cervical squamous cell carcinoma PMID: 23765377
    16. A unique loop structure in oncostatin M determines binding affinity toward oncostatin M receptor and leukemia inhibitory factor receptor. PMID: 22829597
    17. enhanced production by beta-defensin-2 in T cells PMID: 22137028
    18. This study identified a new heterozygous OSMR missense mutation in primary localized cutaneous amyloidosis. PMID: 22062952
    19. An alternatively spliced variant of OSMR transcribing a soluble form of this receptor has been characterized in esophageal squamous cell carcinoma. PMID: 21394648
    20. We conclude that OSMR overexpression in cervical SCC cells provides increased sensitivity to OSM, which induces pro-malignant changes. PMID: 21952923
    21. Aberrant methylation of the OSMR gene is associated with non-invasive colorectal cancer. PMID: 21508378
    22. Two new pathogenic heterozygous missense mutations in the OSMR gene (p.Val631Leu and p.Asp647Tyr) were identified in two Dutch familial primary localized cutaneous amyloidosis families. PMID: 20507362
    23. study provides evidence for the existence of a novel pathogenic mutation in the OSMR gene in a caucasian family with familial primary cutaneous amyloidosis PMID: 19466957
    24. The identification of OSMR and IL31RA gene pathology provides an explanation of the high prevalence of primary cutaneous amyloidosis in Taiwan as well as new insight into disease pathophysiology. PMID: 19690585
    25. provides a biologic rationale for silencing of OSMR in colon cancer progression and highlight a new therapeutic target. Moreover, detection and quantification of OSMR promoter methylation in fecal DNA is a highly specific diagnostic biomarker for CRC PMID: 19662090
    26. expression and evidence for STAT3 activation in human ovarian carcinomas PMID: 12061840
    27. The expression of OSM and its receptor in ovarian tissue from fetuses and women suggests a possible role of OSM in growth initiation of human primordial follicles. PMID: 15831292
    28. sOSMR is able to bind OSM and interleukin-31 when associated to soluble gp130 or soluble interleukin-31R, respectively, and to neutralize both cytokine properties PMID: 17028186
    29. FPLCA has been mapped to 5p13.1-q11.2, and by candidate gene analysis, study identified missense mutations in the OSMR gene, encoding oncostatin M-specific receptor beta (OSMRbeta), in three families. PMID: 18179886
    30. murine OSMR initiates STAT5 activation directly via the receptor bound Janus kinases. Intriguingly, the murine receptor preferentially recruits JAK2, whereas the human receptor seems to have a higher affinity for JAK1. PMID: 18430728
    31. IL-6 and Oncostatin M individually affect the profile of leukocyte trafficking PMID: 18641356
    32. The renal parenchyma is capable of generating a strong acute phase response, likely mediated via OSM/OSMR. PMID: 19158344
    33. Epigenetic silencing and DNA methylation of OSMR is associated with colorectal cancers. PMID: 19223499
    34. study reporta a Japanese family with familial primary localized cutaneous amyloidosis in whom a novel OSMR mutation was observed PMID: 19375894

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  • 相關(guān)疾病：
    Amyloidosis, primary localized cutaneous, 1 (PLCA1)
  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Type I cytokine receptor family, Type 2 subfamily
  • 組織特異性：
    Expressed in keratinocytes (at protein level). Expressed at relatively high levels in all neural cells as well as fibroblast and epithelial cells.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 8507

    OMIM: 105250

    KEGG: hsa:9180

    STRING: 9606.ENSP00000274276

    UniGene: Hs.120658



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