NPR1 (REGN-7544 Biosimilar) Recombinant Monoclonal Antibody
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貨號(hào):CSB-RA016023MB2HU
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規(guī)格:¥83486
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:NPR1(REGN-7544 Biosimilar Antibody)重組單克隆抗體)是一種通過(guò)基因工程技術(shù)制備的生物制劑,專為科研用途設(shè)計(jì)。該產(chǎn)品以重組DNA技術(shù)為基礎(chǔ),在哺乳動(dòng)物細(xì)胞表達(dá)系統(tǒng)中進(jìn)行高效表達(dá),確??贵w分子的正確折疊與翻譯后修飾,從而維持其結(jié)構(gòu)完整性和生物學(xué)活性。 作為單克隆抗體,NPR1具有高度均一性和靶向特異性,可特異性識(shí)別并結(jié)合其靶標(biāo)分子,為生命科學(xué)研究提供可靠的工具。其生產(chǎn)過(guò)程嚴(yán)格遵循生物制藥級(jí)別的質(zhì)量控制標(biāo)準(zhǔn),通過(guò)多步純化工藝去除雜質(zhì),保證產(chǎn)品的高純度和低內(nèi)毒素水平,滿足細(xì)胞培養(yǎng)、蛋白質(zhì)相互作用分析、免疫檢測(cè)等多種實(shí)驗(yàn)需求。 在科研應(yīng)用中,NPR1可廣泛用于靶點(diǎn)驗(yàn)證、信號(hào)通路研究、疾病模型構(gòu)建等領(lǐng)域。例如,通過(guò)特異性結(jié)合靶蛋白,可探究其在生理或病理過(guò)程中的功能機(jī)制;在細(xì)胞實(shí)驗(yàn)中,可用于檢測(cè)靶分子的表達(dá)水平或進(jìn)行亞細(xì)胞定位分析;在動(dòng)物實(shí)驗(yàn)中,可作為工具抗體研究相關(guān)疾病的發(fā)病機(jī)制。 該產(chǎn)品僅用于科研目的,不用于臨床治療或診斷。其穩(wěn)定的批次間一致性和明確的生物學(xué)活性,為科研人員提供了可重復(fù)的實(shí)驗(yàn)結(jié)果保障,有助于推動(dòng)免疫學(xué)、細(xì)胞生物學(xué)、分子生物學(xué)等領(lǐng)域的基礎(chǔ)研究和應(yīng)用探索。
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Uniprot No.:
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基因名:
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別名:REGN7544 research-grade biosimilar; REGN 7544 research-grade biosimilar ;NPR1 antibody; ANPRA antibody; Atrial natriuretic peptide receptor 1 antibody; EC 4.6.1.2 antibody; Atrial natriuretic peptide receptor type A antibody; ANP-A antibody; ANPR-A antibody; NPR-A antibody; Guanylate cyclase A antibody; GC-A antibody
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反應(yīng)種屬:Human
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免疫原:Recombinant Human NPR1 protein
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
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克隆類型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產(chǎn)品提供形式:Liquid
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應(yīng)用說(shuō)明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:3-4 weeks
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.
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基因功能參考文獻(xiàn):
- These results of the distinct presence of NPRA and NPRBpositive cells in unstable plaques underlying acute myocardial infarction suggested that natriuretic peptides serve a role in regulating plaque instability in humans. PMID: 28765884
- The results indicate that the inhibition of NPRA suppresses gastric cancer development and targeting NPRA may represent a promising strategy for the treatment of gastric cancer. PMID: 27634171
- Data suggest that signaling via ANP/ANPR (atrial natriuretic factor/ANP receptor) in vascular endothelial cells activates PAK4 (p21-activated kinase 4) and CCM2 (cerebral cavernous malformation 2 protein), resulting in phosphorylation of MLC (myosin light chain), cytoskeletal reorganization, and cell spreading; kinase homology domain of ANPRA (guanylyl cyclase-A) activates downstream targets of ANP/ANPR signaling. PMID: 28432261
- After ligand binding, NPRA is rapidly internalized and trafficked from the cell surface into endosomes, Res and lysosomes, with concurrent generation of intracellular cyclic GMP in HEK-293 cells. PMID: 26374856
- Data suggest up-regulation of NPRA in skeletal muscle (SM) correlates with whole-body insulin sensitivity; NPRA is down-regulated in SM in obese subjects compared to normal controls; NPRA in SM is up-regulated in response to diet-induced weight loss. PMID: 26253614
- In this review we highlight the mechanisms by which NPR-A affects signaling pathways involved in inflammation and cancer, and we discuss its potential as a novel target in inflammation, cancer, and cancer-related inflammation PMID: 25955817
- NPRA was detected in E11.5 cardiac progenitor cells. PMID: 25631869
- Cardiac fibrosis and the endogenous natriuretic peptide system were evaluated in end-stage heart failure to assess the anti-fibrotic actions of the dual GC-A/-B activator. PMID: 25117468
- High NPR1 expression is associated with esophageal squamous cell carcinomas. PMID: 24885858
- Molecular dynamics analysis indicated decreases in the values of Van der Waals, electrostatic energy and potential energy of NPRB/Vasonatrin peptide compared to NPRA/Vasonatrin peptide. PMID: 24699414
- ACNP stimulated both human natriuretic peptide receptors (NPRs), NPRA and NPRB, as potent as their native ligands in receptor transfected cells. PMID: 23186809
- Guanylyl cyclases A and B are asymmetric dimers that are allosterically activated by ATP binding to the catalytic domain. PMID: 22949736
- human ventricular cardiomyocytes express low levels of GC-A and GC-A in cardiomyocytes from failing human hearts is refractory to ANP stimulation. PMID: 22133375
- Results demonstrate the opposite effects of NPR-A and NPR-C in LPS-mediated endothelial permeability and lung injury. PMID: 22001395
- Cellular exposure to Go6976 reduced basal and natriuretic peptide-dependent, but not detergent-dependent, GC-A and GC-B activity. PMID: 21366551
- Go6976 reduces GTP binding to the catalytic site of GC-A and GC-B and that ATP increases the magnitude of the inhibition. PMID: 21828054
- Midregional pro-A-type natriuretic peptide has a comparable accuracy to brain natriuretic peptide BNP for evaluation of cardiocirculatory exercise limitation. PMID: 20034689
- NPRA promotes prostate cancer development in part by regulating macrophage migration inhibitory factor PMID: 21586128
- review attempts to provide insights and to delineate the current concepts in the field of functional genomics and signaling of GC-A/NPRA in hypertension and cardiovascular disease states at the molecular level PMID: 21375691
- we identified and characterized new phosphorylation sites in GC-A and GC-B and provide the first evidence of phosphorylation sites within human guanylyl cyclases. PMID: 20977274
- The SS genotype of the AGT gene was related with an increased risk for 3-vessel CAD PMID: 20529973
- kinetics of internalization, trafficking, and down-regulation of recombinant guanylyl cyclase/natriuretic peptide receptor-A (NPRA) PMID: 11704663
- unlikely that NPR1 is the same as the MCKD1 gene, mutations in which cause the adult form of medullary cystic kidney disease type 1; however, it is presently unknown whether it plays a disease modifying role PMID: 11851379
- This gene codes for natriuretic peptide receptor A, which mediates natriuretic, diuretic, and vasorelaxing actions of the natriuretic peptides. PMID: 12483301
- The "deletion 15129" variant might participate in the functional impairment of natriuretic peptide system defining and increased genetic susceptibility to hypertension. PMID: 12506509
- activation stabilizes a membrane-distal dimer interface PMID: 12547834
- Human dendritic cells, but not monocytes, express functional ANP receptor GC-A at both mRNA and protein levels. PMID: 12794112
- NPRA-PKG association may have a role in compartmentation of cGMP-mediated signaling and regulation of receptor sensitivity PMID: 12855709
- The novel Npr1 gene 3C variant and the Npr3 gene C(-55) allele are associated with hypertensive family history PMID: 12872042
- the M341I missense mutation is associated with risk of myocardial infarct (MI) and may be a genetic marker of MI PMID: 14646971
- NPR-A and NPR-B are desensitized in cells in which they are not internalized. PMID: 15459247
- discussion of experimental insights into the mechanisms that cells utilize in modulating the delivery and metabolic processing of ligand-bound NPRA into the cell interior [review] PMID: 15911067
- discussion of the functional significance of the promoter region of Npr1 gene and its transcriptional regulation [review] PMID: 15911069
- ATP does not activate NPRA and NPRB as has been repeatedly reported. Instead, ATP increases activity primarily by maintaining proper receptor phosphorylation status but also serves a previously unappreciated enzyme stabilizing function. PMID: 15911610
- interaction of atrial natriuretic peptide with natriuretic peptide receptor-A modulates the binding of ATP to the kinase homology domain PMID: 16262696
- NPR-A protein localized to cardiomyocytes, endocardial endothelial cells, and smooth muscle of intramyocardial vessels; downregulation in the density of NPR-A in heart and coronary was observed in artery of patients with ischemic heart disease PMID: 16778132
- Data suggest that natriuretic peptide receptor A (NPR-A) interacts with fibronectin to enhance brain natriuretic peptide (BNP) activation of cyclic GMP and that a small NPR-A-specific RGD peptide augments this action of BNP. PMID: 16986166
- In patients with Dukes stage C/D colorectal cancer, the Cox Proportional Hazard Model analysis demonstrated a significant association between increased patient survival and low expression of ITGB2 (p = 0.011) and NPR1 (p = 0.023) genes. PMID: 18306933
- Real-time PCR revealed that large adipocytes expressed higher mRNA levels of NPRA, and binding studies showed that large adipocytes expressed more NPR-A on the membrane than small adipocytes. PMID: 18383440
- The "4-minus" haplotype of the NPR-A receptor gene is associated with high NT-proBNP values and is a genetic determinant of the interindividual variability in the BNP system in healthy individuals but probably not in patients with cardiovascular disease. PMID: 18436476
- In the present study conducted in a homogeneous Hellenic population, no associations between Angiotensinogen,angiotensin-converting enzyme, and NPRA gene polymorphisms and hypertension were found. PMID: 19126660
- These results indicate that the ANP/GC-A system is involved in immune regulation through plasmacytoid dendritic cells in secondary lymphoid organs. PMID: 19563399
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亞細(xì)胞定位:Membrane; Single-pass type I membrane protein.
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蛋白家族:Adenylyl cyclase class-4/guanylyl cyclase family
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