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  4. MYL9 (US10513561B2 Biosimilar) Recombinant Monoclonal Antibody

MYL9 (US10513561B2 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA015318MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    MYL9（US10513561B2 Biosimilar Antibody）重組單克隆抗體是一種針對人肌球蛋白調(diào)節(jié)輕鏈9。其靶點MYL9具有多個別名，包括肌球蛋白調(diào)節(jié)輕多肽9、20 kDa肌球蛋白輕鏈、LC20、MLC-2C、肌球蛋白RLC、平滑肌亞型肌球蛋白調(diào)節(jié)輕鏈2、肌球蛋白調(diào)節(jié)輕鏈9、肌球蛋白調(diào)節(jié)輕鏈MRLC1等，這些別名反映了該蛋白在不同研究場景下的命名習慣。該抗體以重組人MYL9蛋白制備，種屬反應性明確為人類，確保了其在人源樣本研究中的特異性結(jié)合能力。 US10513561B2 Biosimilar Antibody作為靶向以MYL9抗體，US10513561B2的類似物研發(fā)聚焦于驗證其與原研藥在分子結(jié)構(gòu)、生物學活性及臨床療效等方面的相似性。MYL9作為肌球蛋白調(diào)節(jié)輕鏈家族成員，參與平滑肌收縮、細胞遷移等重要生理過程，其表達異常與心血管疾病、腫瘤侵襲轉(zhuǎn)移等多種疾病密切相關(guān)。相關(guān)研究表明，MYL9的磷酸化狀態(tài)可作為評估血管平滑肌收縮功能的生物標志物，而針對MYL9的靶向藥物干預可能為高血壓、動脈粥樣硬化等疾病提供新的治療思路。 MYL9重組單克隆抗體憑借高特異性和親和力，廣泛應用于實驗，助力研究人員解析MYL9在細胞信號通路中的作用機制。例如，通過檢測不同病理狀態(tài)下組織或細胞中MYL9的表達水平及亞細胞定位，可深入探討其在腫瘤微環(huán)境重塑、血管生成等過程中的功能。此外，該抗體為人源特異性，避免了交叉反應干擾，適用于人類細胞系、組織樣本及臨床標本的研究，為轉(zhuǎn)化醫(yī)學研究提供了可靠的工具支持。隨著研究的深入，MYL9抗體有望在疾病機制研究和潛在藥物靶點篩選中發(fā)揮更重要的作用。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Myosin regulatory light polypeptide 9；20 kDa myosin light chain；LC20；MLC-2C；Myosin RLC；Myosin regulatory light chain 2, smooth muscle isoform；Myosin regulatory light chain 9；Myosin regulatory light chain MRLC1, MYL9, MLC2 MRLC1 MYRL2
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human MYL9 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion. In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation.
  • 基因功能參考文獻：
    1. MYL9 expression might be a promising prognostic marker and therapeutic target in ESCC PMID: 28388691
    2. At the cleavage furrow Arv1 recruits myosin heavy chain 9 (MYH9) and myosin light chain 9 (MYL9) by interacting with IQ-motif-containing GTPase-activating protein (IQGAP1). PMID: 27104745
    3. These findings suggested that low MYLK and MYL9 expressions might be associated with the development of NSCLC. PMID: 25179839
    4. the decreased expression of MYL9 may play an important role in tumor progression of prostate cancer PMID: 24338276
    5. Overexpression of MRTF-A significantly promoted the migration of MCF-7 cells through its transactivation effects on MYL9 and CYR61 genes PMID: 24084383
    6. Overexpression of SMYD3 promotes MRTF-A-mediated upregulation of MYL9 and migration of MCF-7 breast cancer cells PMID: 24189459
    7. surface CD3 expression proceeds through both MYL9-dependent and MYL9-independent pathways (i.e. the protein kinase C- dependent pathway) in Jurkat cells. PMID: 23538510
    8. The FHC-mediated structural perturbations in RLC that affect Ca(2+) binding properties of mutated myocardium are responsible for triggering the abnormal function of the heart that in turn might initiate a hypertrophic process and lead to heart failure. PMID: 16076902
    9. Smooth muscle type isoform, MLC-2C, is the inducible isoform, and might play a crucial role in monocyte/macrophage cell lineage. PMID: 18480596
    10. use of a shRNA to decrease MYL9 expression showed that MYL9 was involved in proplatelet formation PMID: 19724058

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  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
  • 組織特異性：
    Smooth muscle tissues and in some, but not all, nonmuscle cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15754

    OMIM: 609905

    KEGG: hsa:10398

    STRING: 9606.ENSP00000279022

    UniGene: Hs.504687



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