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  4. MUC17 (US8546546B2 Biosimilar) Recombinant Monoclonal Antibody

MUC17 (US8546546B2 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA727848MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    MUC17重組單克隆抗體（US8546546B2 Biosimilar Antibody）是一種針對黏蛋白家族成員MUC17的生物治療藥物，其別名為Mucin-17、MUC-3、Small intestinal mucin-3等。該抗體以重組人MUC17蛋白制備，具有高度的種屬反應(yīng)性，主要針對人類MUC17蛋白發(fā)揮作用。MUC17作為一種跨膜黏蛋白，主要表達(dá)于小腸、結(jié)腸等消化道上皮細(xì)胞表面，在維持黏膜屏障完整性、細(xì)胞黏附及信號轉(zhuǎn)導(dǎo)中發(fā)揮重要生理功能。 以MUC17為靶點(diǎn)的生物治療藥物開發(fā)聚焦于消化道疾病的治療潛力。研究表明，MUC17的異常表達(dá)或功能失調(diào)與炎癥性腸?。ㄈ缈肆_恩病、潰瘍性結(jié)腸炎）、消化道腫瘤（如結(jié)直腸癌）等疾病密切相關(guān)。通過特異性結(jié)合MUC17，此類藥物可能調(diào)節(jié)黏膜免疫微環(huán)境、抑制腫瘤細(xì)胞增殖或侵襲，目前已有多項(xiàng)臨床前研究驗(yàn)證其在改善腸道炎癥、減少腫瘤轉(zhuǎn)移風(fēng)險(xiǎn)中的作用，部分研究正逐步向早期臨床試驗(yàn)推進(jìn)。 該抗體為MUC17相關(guān)機(jī)制研究提供了關(guān)鍵工具。研究者可利用其特異性識別能力，通過技術(shù)分析MUC17在正常及病理組織中的表達(dá)定位；在細(xì)胞模型中，通過抗體阻斷實(shí)驗(yàn)探索MUC17對細(xì)胞遷移、黏附及信號通路的影響；此外，該抗體還可與其他分子探針偶聯(lián)，用于活體成像研究，助力揭示MUC17在消化道生理病理過程中的分子機(jī)制，為相關(guān)疾病的診斷標(biāo)志物發(fā)現(xiàn)及治療靶點(diǎn)開發(fā)奠定基礎(chǔ)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Mucin-17, MUC-17, Small intestinal mucin-3；MUC-3, MUC17, MUC3
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human MUC17 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Probably plays a role in maintaining homeostasis on mucosal surfaces.
  • 基因功能參考文獻(xiàn)：
    1. MUC17 polymorphisms are involved in endometriosis development and the associated infertility in the Taiwanese population. PMID: 26285705
    2. Carbachol stimulated enterocyte MUC17 endocytosis is concomitant with NHE3 internalization and CFTR membrane recruitment. PMID: 23784542
    3. The HIF1alpha-mediated hypoxic signal pathway contributes to MUC17 expression, and DNA methylation of hypoxia responsive element could be a determinant of the hypoxic inducibility of MUC17 in pancreatic cancer cells. PMID: 22970168
    4. Both native and exogenous MUC17 play a role in attachment and invasion of enteroinvasive E. coli in colonic cell lines and in maintaining epithelial barrier function. PMID: 21393431
    5. Hypomethylation status in the MUC17 promoter could be a novel epigenetic marker for the diagnosis of Pancreatic ductal adenocarcinomas. PMID: 20926598
    6. Results indicate that the potential protective effects of this membrane-bound mucin are primarily or secondarily diminished in inflammatory and neoplastic conditions. PMID: 20702471
    7. augments intestinal cell restitution and enhances healing of experimental colitis in mice PMID: 20211273
    8. The authors demonstrate that apically atypical enteropathogenic Escherichia coli infection is followed by increased production of secreted MUC2 and MUC5AC mucins and membrane-bound MUC3 and MUC4 mucins. PMID: 20065027
    9. sequence homology & chromosome mapping PMID: 11855812
    10. surface localization of the smaller subunit of MUC17 is dependent on its N-glycosylation status PMID: 12888891
    11. The MUC17 sequence has been extended toward its 5'-extremity to complete the sequence and localize the promoter and regulatory elements. PMID: 16737958
    12. Pdzk1 plays a specific role in stabilizing Muc17 in the apical membrane of small intestinal enterocytes. PMID: 17990980

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  • 亞細(xì)胞定位：
    [Isoform 1]: Cell membrane; Single-pass membrane protein.; [Isoform 2]: Secreted. Cell membrane.
  • 組織特異性：
    Expressed almost exclusively in the intestine. Expression is especially high in both the duodenum and transverse colon. Expressed in mature absorptive cells of the small intestinal villi. No expression is detected in goblet cells. Highly expressed in panc
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16800

    OMIM: 608424

    KEGG: hsa:140453

    STRING: 9606.ENSP00000302716

    UniGene: Hs.271819



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