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  4. MUC13 (WO2016168607A1 Biosimilar) Recombinant Monoclonal Antibody

MUC13 (WO2016168607A1 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA887973MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    MUC13重組單克隆抗體（WO2016168607A1 Biosimilar Antibody）是一種針對(duì)黏蛋白13（Mucin 13）的生物治療藥物，其別名為結(jié)腸癌下調(diào)蛋白1抗體（DRCC1 antibody）、MUC 13抗體、Muc13_HUMAN抗體等，還包括FLJ20063、PRO20221、RECC、UNQ6194等多種科研用標(biāo)識(shí)。該抗體以重組人MUC13蛋白制備，具有高度的種屬特異性，僅對(duì)人源MUC13蛋白產(chǎn)生免疫反應(yīng)。 該抗體研發(fā)的藥物針對(duì)MUC13這一細(xì)胞表面相關(guān)黏蛋白靶點(diǎn)，其表達(dá)異常與多種惡性腫瘤密切相關(guān)，尤其在結(jié)腸癌中被發(fā)現(xiàn)存在表達(dá)下調(diào)現(xiàn)象，提示其可能參與腫瘤發(fā)生發(fā)展的調(diào)控機(jī)制。目前該抗體研發(fā)的藥物的研究主要聚焦于探索其在腫瘤診斷、預(yù)后評(píng)估及靶向治療中的潛力，例如通過阻斷MUC13介導(dǎo)的細(xì)胞信號(hào)通路，抑制腫瘤細(xì)胞增殖或促進(jìn)免疫細(xì)胞對(duì)腫瘤的識(shí)別。 MUC13抗體廣泛用于基礎(chǔ)研究中的蛋白質(zhì)定位、表達(dá)分析及功能驗(yàn)證。借助實(shí)驗(yàn)，研究人員可深入探究MUC13在正常組織與病變組織中的表達(dá)差異，揭示其在細(xì)胞黏附、信號(hào)轉(zhuǎn)導(dǎo)及腫瘤微環(huán)境調(diào)控中的作用。此外，該抗體也為開發(fā)基于MUC13的診斷試劑和新型抗腫瘤藥物提供了重要的工具支持。 作為其，該抗體的研發(fā)嚴(yán)格遵循生物制品相關(guān)技術(shù)標(biāo)準(zhǔn)，旨在通過與藥物發(fā)現(xiàn)的陽性對(duì)照高度相似的結(jié)構(gòu)和功能，為疾病治療提供更可及的治療選擇。未來，隨著對(duì)MUC13生物學(xué)功能的深入解析，其在個(gè)體化醫(yī)療和精準(zhǔn)治療中的應(yīng)用前景將進(jìn)一步拓展。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Down-regulated in colon cancer 1 antibody; DRCC1 antibody; FLJ20063 antibody; MUC 13 antibody; MUC-13 antibody; Muc13 antibody; MUC13 Down regulated in colon cancer 1 antibody; MUC13_HUMAN antibody; Mucin 13; cell surface associated antibody; Mucin-13 antibody; PRO20221 antibody; RECC antibody; UNQ6194 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human MUC13 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Epithelial and hemopoietic transmembrane mucin that may play a role in cell signaling.
  • 基因功能參考文獻(xiàn)：
    1. The results suggest that MUC13 overexpression and loss of expression of AGR2 may predict the progression of Intraductal papillary mucinous neoplasm and an unfavorable prognosis in patients with Intraductal papillary mucinous neoplasm PMID: 29650332
    2. our study first demonstrated that USF1 could activate the transcription of MUC13, thereby enhancing the proliferation and self-renewal of glioblastoma stem cells PMID: 29441861
    3. MUC13 high expression is a novel independent adverse prognostic factor of clinical outcome in non-metastatic clear cell renal cell carcinoma patients after surgery. PMID: 27911274
    4. Luciferase assays and western blot confirmed MUC13 as a target gene of miR1323p. PMID: 28339011
    5. Results from this study demonstrate that MUC13 Functionally interacts and activates HER2 at p1248 in PDAC cells, leading to stimulation of HER2 signaling cascade, including ERK1/2, FAK, AKT and PAK1 as well as regulation of the growth, cytoskeleton remodeling and motility, invasion of PDAC cells-all collectively contributing to PDAC progression. PMID: 27321183
    6. High MUC13 expression is associated with renal cell carcinoma and drug resistance. PMID: 28205224
    7. A combination of MUC13/MUC20 expression was a potential prognostic marker for patients with ESCC, who received neoadjuvant chemotherapy followed by surgery. PMID: 26323930
    8. Results show that pancreatic ductal adenocarcinoma cells express higher levels of MUC13 and is associated with poor outcome when expressed at low level. PMID: 25672256
    9. Based on nasopharyngeal MUC13 gene expression in readily available Nasopharyngeal aspirate samples , we can discriminate between severity of disease in Respiratory syncytial virus infected infants. PMID: 25261323
    10. These results suggest miR-145 as a novel regulator of MUC13 in pancreatic cancer. PMID: 25277192
    11. Overexpression of MUC13 increased cell growth, colony formation, cell migration, and invasion in colon cancer cells. PMID: 24097071
    12. MUC13 is epigenetically regulated in ovarian cancer. PMID: 25048476
    13. Overexpression of MUC13 is associated with pancreatic neuroendocrine tumors. PMID: 24114056
    14. GALNT14 may contribute to ovarian carcinogenesis through aberrant glycosylation of MUC13. PMID: 23708057
    15. Metastatic colon cancer and liver metastasis tissue samples demonstrated significantly (p<0.05) higher cytoplasmic and nuclear MUC13 expression compared with non-metastatic colon cancer and adjacent normal colon samples. PMID: 22914648
    16. MUC13 overexpression caused a significant increase in cell motility, invasion, proliferation, and anchorage-dependent or -independent clonogenicity while decreasing cell-cell and cell-substratum adhesion in pancreatic cancer. PMID: 22027689
    17. The various functional domains of MUC13 may confer oncogenic potential to MUC13 PMID: 21450906
    18. MUC13 is a good differentiation marker for gastrointestinal mucosa PMID: 15904467
    19. Aberrant intestinal expression and allelic variant MUC13 is associated with inflammatory bowel disease. PMID: 17058067
    20. Reflux laryngitis is associated with down-regulation of mucin gene expression. PMID: 18834073
    21. Findings show the aberrant expression of MUC13 in ovarian cancer and that its expression alters the cellular characteristics of SKOV-3 cells. This implies a significant role of MUC13 in ovarian cancer. PMID: 19176398

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Apical cell membrane. Secreted. Note=Also exists as a soluble form.
  • 組織特異性：
    Highly expressed in epithelial tissues, particularly those of the gastrointestinal and respiratory tracts, such as large intestine and trachea, followed by kidney, small intestine, appendix and stomach.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7511

    OMIM: 612181

    KEGG: hsa:56667

    STRING: 9606.ENSP00000312235

    UniGene: Hs.5940



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