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  4. MOSPD2 (IW-601 Biosimilar) Recombinant Monoclonal Antibody

MOSPD2 (IW-601 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA839916MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    MOSPD2（IW-601 Biosimilar Antibody)重組單克隆抗體是一種針對MOSPD2靶點開發(fā)的生物工程抗體。MOSPD2作為一種跨膜蛋白，在細(xì)胞生物學(xué)研究中具有重要意義，其參與細(xì)胞信號轉(zhuǎn)導(dǎo)、膜蛋白運輸及細(xì)胞間相互作用等多種生理過程，相關(guān)機(jī)制研究涉及腫瘤發(fā)生、免疫調(diào)控等多個領(lǐng)域。 該抗體通過重組DNA技術(shù)在哺乳動物細(xì)胞表達(dá)系統(tǒng)中制備，經(jīng)Protein A親和層析、離子交換層析等多步純化工藝獲得高純度產(chǎn)品，具有特異性強(qiáng)、批次間穩(wěn)定性好的特點。其抗原結(jié)合片段（Fab）可精準(zhǔn)識別MOSPD2胞外結(jié)構(gòu)域的保守表位，在某些實驗中表現(xiàn)出優(yōu)異的檢測性能，能有效用于細(xì)胞或組織樣本中MOSPD2蛋白的定性分析與亞細(xì)胞定位研究。 作為科研工具，該抗體為探索MOSPD2的生物學(xué)功能提供了關(guān)鍵實驗材料。研究人員可利用其進(jìn)行蛋白質(zhì)相互作用分析（如Co-IP）、檢測及基因編輯細(xì)胞系的驗證某些實驗，助力揭示MOSPD2在疾病模型中的作用機(jī)制。產(chǎn)品嚴(yán)格按照科研試劑標(biāo)準(zhǔn)生產(chǎn)，通過無菌過濾處理，不含防腐劑，推薦儲存于-20℃條件下，避免反復(fù)凍融以保證活性。使用時需根據(jù)具體實驗需求優(yōu)化稀釋比例，建議進(jìn)行預(yù)實驗確定最佳工作濃度。
  • Uniprot No.：
  • 基因名：
  • 別名：
    MOSPD2 antibody; Motile sperm domain-containing protein 2 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human MOSPD2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Endoplasmic reticulum-anchored receptor which modulates interorganelle contacts by interacting with other organelle-bound proteins via their FFAT motif. Might have a more important role in endoplasmic reticulum and endosomes contacts. Promotes migration of primary monocytes and neutrophils, in response to various chemokines.
  • 基因功能參考文獻(xiàn)：
    1. this study shows that silencing MOSPD2 inhibited signaling events following chemokine receptor ligation and monocyte migration induced by chemokines PMID: 28137892
  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
  • 組織特異性：
    Highly expressed in CD14(+) monocytes, and at lower levels in neutrophils. Does not show significant expression in B-cells or T-cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28381

    KEGG: hsa:158747

    STRING: 9606.ENSP00000369860

    UniGene: Hs.744919



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