MICA/B（CLN-619 Biosimilar Antibody）重組單克隆抗體是一種針對MHC I類鏈相關(guān)蛋白（MICA/B），其靶點MICA/B全稱為MHC class I polypeptide-related sequence A/B，別名包括MHC Class I chain-related protein、MICA及CLN-619。該抗體以重組人MICA/B蛋白制備而成，具有明確的抗原結(jié)合特異性。 CLN-619 Biosimilar Antibody作為靶向MICA/B抗體，CLN-619的類似物，利用MICA/B作為NK細胞活化性受體NKG2D重要配體的特性，通過特異性結(jié)合腫瘤細胞表面高表達的MICA/B，阻斷其與NKG2D的相互作用，恢復(fù)NK細胞對腫瘤細胞的殺傷活性，目前正被探索用于多種實體瘤（如結(jié)直腸癌、肺癌等）的免疫治療。臨床前研究顯示，該抗體研發(fā)的藥物能有效抑制腫瘤生長并增強免疫檢查點抑制劑的療效，相關(guān)臨床試驗已進入早期階段，重點評估其安全性及抗腫瘤活性。 MICA/B重組單克隆抗體可用于檢測細胞表面MICA/B的表達水平，助力腫瘤微環(huán)境免疫機制研究。因其種屬反應(yīng)性覆蓋人（Human）和食蟹猴（Macaca fascicularis），適用于人類疾病模型及非人靈長類動物實驗，為抗體類似物的臨床前藥效驗證提供有力工具。此外，該抗體還推動MICA/B在自身免疫性疾病、感染性疾病等領(lǐng)域的基礎(chǔ)研究。 綜上，MICA/B（CLN-619 Biosimilar Antibody）作為靶向MICA/B的重組單克隆抗體，不僅在腫瘤免疫治療領(lǐng)域顯示出潛在價值，也為科研人員深入探究MICA/B相關(guān)的免疫調(diào)控機制提供了可靠的實驗試劑。

J9TPG6

MICA/B

MHC Class I chain-related protein; MHC class I polypeptide-related sequence A; MICA; CLN-619

Human

Recombinant Human MICA/B protein

Homo sapiens (Human)

Non-conjugated

Monoclonal

It differs from different batches. Please contact us to confirm it.

0.01M PBS，pH7.4

Liquid

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

In stock

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.