MASP2 (TST-004 Biosimilar) Recombinant Monoclonal Antibody
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貨號(hào):CSB-RA013510MB5HU
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規(guī)格:¥83486
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:MASP2 (TST-004 Biosimilar Antibody)重組單克隆抗體是一種專為科研用途開發(fā)的生物制劑,其核心作用靶點(diǎn)為甘露糖結(jié)合凝集素相關(guān)絲氨酸蛋白酶2(MASP2)。該抗體通過基因工程技術(shù)在哺乳動(dòng)物細(xì)胞中重組表達(dá),具有高純度、高特異性和批次穩(wěn)定性的特點(diǎn),為補(bǔ)體系統(tǒng)替代途徑相關(guān)的基礎(chǔ)研究與機(jī)制探索提供了可靠工具。 MASP2作為補(bǔ)體凝集素途徑的關(guān)鍵效應(yīng)酶,在先天免疫應(yīng)答中通過激活下游級(jí)聯(lián)反應(yīng)介導(dǎo)病原體清除與炎癥調(diào)控。該重組單克隆抗體可特異性識(shí)別并結(jié)合MASP2的催化結(jié)構(gòu)域或調(diào)節(jié)區(qū)域,實(shí)現(xiàn)對(duì)其酶活性的精準(zhǔn)抑制或功能阻斷,適用于細(xì)胞模型、動(dòng)物模型及體外生化實(shí)驗(yàn)等多場(chǎng)景研究需求。 產(chǎn)品采用無動(dòng)物源成分的培養(yǎng)體系生產(chǎn),經(jīng)Protein A親和層析與離子交換層析等多步純化工藝獲得,SDS-PAGE檢測(cè)顯示單體條帶清晰,內(nèi)毒素含量<0.1 EU/μg,滿足嚴(yán)格的科研標(biāo)準(zhǔn)。在應(yīng)用中,可通過及功能性抑制實(shí)驗(yàn)等方法,深入探究MASP2在自身免疫疾病、感染性疾病及腫瘤微環(huán)境中的作用機(jī)制。 該抗體為凍干制劑,復(fù)溶后可在-20℃長(zhǎng)期保存,避免反復(fù)凍融。其研發(fā)嚴(yán)格遵循GMP級(jí)質(zhì)量管理規(guī)范,確保每批次產(chǎn)品的生物學(xué)活性與理化性質(zhì)一致性,為補(bǔ)體系統(tǒng)功能研究、藥物靶點(diǎn)驗(yàn)證及疾病機(jī)制解析等科研工作提供有力支持。
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Uniprot No.:
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基因名:
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別名:TST004 research-grade biosimilar ;MASP2 antibody; Mannan-binding lectin serine protease 2 antibody; EC 3.4.21.104 antibody; MBL-associated serine protease 2 antibody; Mannose-binding protein-associated serine protease 2 antibody; MASP-2 [Cleaved into: Mannan-binding lectin serine protease 2 A chain antibody; Mannan-binding lectin serine protease 2 B chain] antibody
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反應(yīng)種屬:Human
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免疫原:Recombinant Human MASP2 protein
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
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克隆類型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產(chǎn)品提供形式:Liquid
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應(yīng)用說明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:3-4 weeks
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
相關(guān)產(chǎn)品
靶點(diǎn)詳情
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功能:Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.
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基因功能參考文獻(xiàn):
- High MAp19 concentration is associated with microalbuminuria in newly diagnosed type 1 diabetes. PMID: 28303635
- The complement lectin pathway serine proteases, MASP-1 and MASP-2, can be associated with ischaemic stroke development risk and may participate in pathological events leading to post-ischaemic brain damage. Moreover rs3203210 and rs147270785 single nucleotide polymorphisms in the MASP1 and MASP2 genes, respectively, are strongly associated with ischaemic stroke. PMID: 28720568
- The results of this study show that MASP-2 contributes to severity and outcome in pneumococcal meningitis. In patients with pneumococcal meningitis, MASP-2 concentration was elevated in the CSF and high levels were associated with poor functional outcome. PMID: 28086930
- Genetically determined MASP-2 levels seem to have a two-edge effect in HIV and probably HCV/HBV coinfection, whereas low levels increase the susceptibility to infection, but on the other side protects against AIDS. PMID: 27588826
- MASP-2 was not associated with adverse cardiovascular outcomes in diabetics. PMID: 27055907
- This is the first comprehensive meta-analysis indicates that the MASP-2 functional gene (rs72550870) polymorphism is not associated with the infection diseases, and the key functional gene polymorphism of rs72550870 did not increase susceptibility to the infection diseases. PMID: 27725284
- This study suggests that hMASP-2 can induce a protective efficacy in BCG-infected rabbit skin models, which affects both the progress of lesions and the survival of the mycobacteria within them. PMID: 27585546
- genotype not associated with acute cellular rejection after kidney transplantation PMID: 26924055
- The ficolin-3/MASP-2 complex was significantly lower in the cardiac syndrome X patients compared to controls. PMID: 27312152
- MASP-1 and MASP-2 are activated during blood clotting. This activation is triggered by activated platelets and by the generation of fibrin during thrombotic reactions in vitro and in vivo, and may represent a novel activation/amplification mechanism in thromboinflammation. PMID: 26614707
- MBL2 and MASP2 deficiencies protect against the development of systemic inflammatory response after pediatric cardiac surgery. PMID: 26382056
- Data show that the vector expressing mannose-binding lectin associated protein 19 (MAp19) has been prepared successfully, and can express the target protein (MAp19) in the eukaryotic cells (HeLa cells). PMID: 26728378
- polymorphism of MASP-2 (rs6695096) gene was associated with susceptibility to tuberculosis. PMID: 25312983
- Polymorphisms of mannose-binding lectin (rs7096206) and MASP-2 (rs2273346 and rs6695096) were associated with the susceptibility of tuberculosis, and there were gene-gene interactions among them. PMID: 25887173
- Polymorphisms in MASP1 and MASP2 genes are associated with the susceptibility or protection to infectious diseases. (Review) PMID: 25862418
- MASP2 gene polymorphisms and protein levels seem to play an important role in the development of rheumatic fever and establishment of rheumatic heart disease. PMID: 25318078
- Because MASP-1 and MASP-2 have been shown to interact directly with blood coagulation, elevated levels of these proteins may play a role in the enhanced thrombotic environment and consequent vascular complications in diabetes. PMID: 25533914
- TFPI inhibits lectin pathway of complement activation by direct interaction with MASP-2. PMID: 25359215
- expression of MBL and MASP-2 is altered in ovarian cancer, possibly indicating involvement of the lectin pathway of complement activation in the disease PMID: 25038892
- Both ficolin-3 and MASP-2 levels correlated inversely with the time from the onset of the attack of hereditary angioedema until blood sampling PMID: 25042985
- Study found the first evidence that MASP-2 deficiency might play an important role in the development of RA and articular symptoms among relatives of RA patients. PMID: 24632598
- Bipolar disorder is associated with the MBL2 LXPA haplotype and lower MASP-2 levels. PMID: 24856568
- Data indicate that MASP-1 and MASP-2 can readily form heterodimers after dissociation and re-association, however, in the presence of Ca(2+) exchange of subunits is slow between the homodimers. PMID: 24424083
- low MASP-2 levels increase the susceptibility to leprosy in general and to lepromatous leprosy in particular. MASP2 genotypes and MASP-2 levels might thus be of prognostic value for leprosy progression. PMID: 23935922
- The present study describes an association between a polymorphism in the MASP2 gene and susceptibility to HTLV-1 infection, and provides further evidence of an association between the MBL2 gene and HTLV-1 infection. PMID: 23861212
- MASP-2 levels in the peripheral circulation are significantly reduced in myocardial infarction (MI) patients compared with those of healthy individuals or of coronary artery disease (CAD) patients without acute MI. PMID: 22178059
- results show that SNPS in MASP2 are significantly more susceptible to infectious complications, SIRS and septic shock. PMID: 24227370
- Studies indicate that initiation of lectin compleme pathway leads to activation of the serine proteases MASP-1 and MASP-2 resulting in deposition of C4 on the activator and assembly of the C3 convertase. PMID: 23911397
- collectin-11 associates with all the known MBL-associated serine proteases (MASP-1, MASP-2 and MASP-3) as well as the lectin complement pathway regulator MAP-1. PMID: 23220946
- In this study, we demonstrate that, although MASPs do not directly form heterodimers, the addition of mannan-binding lectin or ficolins allows the formation of MASP-1-MASP-2 co-complexes. PMID: 23785123
- Data indicate that the median concentration of MASP-2/ficolin-3 complexes was 119.7 AU/ml (range: 2.9-615.5 AU/ml). PMID: 23142462
- MASP-2 is a key enzyme that cleaves C4 and C2 to assemble a C3 convertase--{review} PMID: 23402018
- A crucial role of MASP-1 is demonstrated in the activation of MASP-2, as well as of MASP-3, based on a patient harboring a nonsense mutation in the common part of the MASP1 gene. PMID: 22966085
- Monospecific inhibitors show that both mannan-binding lectin-associated serine protease-1 (MASP-1) and -2 Are essential for lectin pathway activation and reveal structural plasticity of MASP-2. PMID: 22511776
- MASP-1 activates MASP-2 and, moreover, inhibition of MASP-1 prevents autoactivation of MASP-2 PMID: 22691502
- A common MASP2 mutation (R439H, rs12085877), was protective against placental malaria and occurred in 33% of non-affected women. PMID: 22380611
- Data show no association of donor and recipient MBL2 and MASP2 genotype with allograft outcome, and analysis of SNPs and haplotypes in the FCN2 gene of the donor and recipient did not reveal an association with transplant outcome. PMID: 22173059
- Interactions required for the cleavage of C4 by MASP-2 are likely to be facilitated by the initial binding of C4 to an exosite on the protease. PMID: 22071314
- In patients with haematological malignancy undergoing chemotherapy, those with low M-ficolin levels were more likely to develop severe infections. PMID: 22236007
- It is postulated that the elevation of concentration of the two components of the leptin pathway, L-ficolin and MASP-2, may compensate for the insufficient activity of the LP in mannose-binding lectin deficiency. PMID: 21974696
- Data show that both MAp19 and MASP-2 were mainly expressed in hepatocytes. PMID: 21871896
- MASP2 gene polymorphism is associated with susceptibility to hepatitis C virus infection. PMID: 21843573
- Results suggest that MBL and MASP-2 play only a minor role in the inflammatory response in acute pancreatitis. PMID: 21926545
- MASP2*CD genotypes, most of them generating low MASP-2 levels, are associated with high risk of chagasic cardiomyopathy PMID: 21489885
- binding of Mannan Binding Lectin to hepatitis C virus glycoproteins was able to activate the complement system via MBL-associated serine protease 2 PMID: 21203938
- In contrast to what has been demonstrated for serum levels of mannan-binding lectin (MBL) and MBL-associated serine protease 2, the genotypes do not predict disease course of the colorectal cancer patients PMID: 21198752
- Donor and recipient gene polymorphisms in the lectin complement pathway (MBL2, FCN2, MASP2) are major determinants of the risk of clinically significant bacterial infection and mortality after orthotopic liver transplantation. PMID: 20593422
- MASP-1 has a crucial role in the initiation steps of lectin pathway activation most probably by activating MASP-2 PMID: 20817870
- The MASP2-mediated release of FPA and FPB may play a role in early immune activation. Additionally, MASP-catalysed deposition and polymerization of fibrin on the surface of micro-organisms may be protective by limiting the dissemination of infection. PMID: 20002787
- the outcome of intensive care unit (ICU) patients with systemic inflammatory response syndrome (SIRS) regarding the existence of functionally relevant MBL2 and MASP2 gene polymorphisms was studied PMID: 20042521
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相關(guān)疾?。?/div>MASP2 deficiency (MASPD)亞細(xì)胞定位:Secreted.蛋白家族:Peptidase S1 family組織特異性:Plasma.數(shù)據(jù)庫鏈接:
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