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  4. MARCO (PY-265 Biosimilar) Recombinant Monoclonal Antibody

MARCO (PY-265 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA880072MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    MARCO (PY-265 Biosimilar Antibody)重組單克隆抗體是一款專為科研用途開發(fā)的生物制劑，其核心成分為重組單克隆抗體。該產(chǎn)品通過先進的基因工程技術(shù)構(gòu)建，旨在為生命科學研究提供高特異性和高親和力的分子工具。 在結(jié)構(gòu)設(shè)計上，MARCO (PY-265 Biosimilar Antibody)重組單克隆抗體采用重組DNA技術(shù)制備，確保了批次間的高度一致性和穩(wěn)定性。其抗體分子經(jīng)過優(yōu)化設(shè)計，能夠特異性識別并結(jié)合靶標分子，為科研人員在蛋白質(zhì)相互作用、信號通路研究、免疫檢測等領(lǐng)域提供可靠支持。 該產(chǎn)品適用于多種實驗場景，包括但不限于、以及酶聯(lián)免疫吸附測定（ELISA）等。在基礎(chǔ)研究中，可用于探索特定蛋白質(zhì)的功能、表達模式及調(diào)控機制；在藥物研發(fā)前期階段，可作為靶點驗證、藥效評估的重要工具。 作為科研用試劑，MARCO (PY-265 Biosimilar Antibody)重組單克隆抗體嚴格遵循質(zhì)量控制標準，通過一系列嚴格檢測確保其純度、活性及特異性。產(chǎn)品提供多種規(guī)格選擇，滿足不同實驗規(guī)模的需求，且配套完整的使用說明，便于科研人員快速上手應(yīng)用。 總之，MARCO (PY-265 Biosimilar Antibody)重組單克隆抗體憑借其高特異性、高穩(wěn)定性和廣泛的適用性，為生命科學研究領(lǐng)域提供了有力的技術(shù)支持，助力科研人員在基礎(chǔ)研究和應(yīng)用研究中取得突破性進展。
  • Uniprot No.：
  • 基因名：
  • 別名：
    PY265 research-grade biosimilar ;MARCO antibody; SCARA2 antibody; Macrophage receptor MARCO antibody; Macrophage receptor with collagenous structure antibody; Scavenger receptor class A member 2 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human MARCO protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria. Also plays a role in binding of unopsonized particles by alveolar macrophages. Binds to the secretoglobin SCGB3A2.
  • 基因功能參考文獻：
    1. the absence of MARCO does not interfere with the efficiency of HSV-1 entry and that the inhibitory effect on viral adsorption by poly(I), a ligand of MARCO, is independent of MARCO. PMID: 29769337
    2. High surface expression of SR-A6 facilitates HAdV-C5 infection. PMID: 29522575
    3. These data suggest the SRCR domain of MARCO is the key domain in modulating ligand binding, enhancing downstream pro-inflammatory signaling and MARCO-mediated cellular adhesion. PMID: 26888252
    4. Expression of MARCO declined progressively as hepatocellular carcinoma condition is aggravated. PMID: 27806438
    5. MARCO single nucleotide polymorphisms rs12998782 increases risk to pulmonary tuberculosis in a Chinese Han population. PMID: 28693442
    6. CD36 and MARCO are associated with the susceptibility of Chinese Han females to carotid atherosclerosis. Menopausal status may affect the association between gene polymorphisms and carotid atherosclerosis in the female Chinese Han population. PMID: 28866086
    7. Increasing MARCO expression by targeting Nrf2 signaling or the Akt-TFEB-MARCO pathway are promising strategies to improve bacterial clearance and survival in postinfluenza bacterial pneumonia. PMID: 28408365
    8. results suggest that MARCO polymorphisms may regulate phagocytosis of M. tuberculosis and susceptibility and severity of pulmonary tuberculosis PMID: 27853145
    9. this paper shows that key gene of intermediate proinflammatory monocytes, such as MARCO, is expressed three- to fourfold more in juvenile idiopathic arthritis-enthesitis-related arthritis PMID: 27706807
    10. this study shows that MARCO modulates inflammatory responses against Cryptococcus neoformans infection PMID: 28298522
    11. this translational investigation identified gene candidates, including Marco, for host susceptibility to multiple phenotypes of RSV disease in mice that closely mimic human disease, and a polymorphism in human MARCO associated with increased risk of RSV disease severity in infants. PMID: 27554839
    12. Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO. PMID: 26892079
    13. identified as a disease-associated molecule in IgG4-related disease by DNA microarray PMID: 26886650
    14. None of the nonsynonymous variants discovered by resequencing of the structurally similar MARCO were associated with lung function or risk of COPD. PMID: 25186548
    15. Vaccinia virus bound directly to MARCO, and overexpression of MARCO increased susceptibility to vaccinia infection. PMID: 25089661
    16. Significant associations of four SNPs and haplotypes with antibody response to cholera vaccine in three genes, MARCO, TNFAIP3 and CXCL12. PMID: 23249958
    17. herpes simplex virus type 1 binds to MARCO to enhance its capacity for disease. PMID: 23739639
    18. We identified 9 non-synonymous variants in the MARCO gene and showed that these variants are not major risk factors for COPD or lung infection. H101Q heterozygotes had increased sepsis risk. PMID: 23154236
    19. Polymorphisms within the human class A scavenger receptor MARCO correlate with susceptibility/resistance to tuberculosis in a Gambian population. PMID: 23617307
    20. In this review, we showed that SR-A and MARCO trigger intracellular signaling, modulating pro-inflammatory and microbicidal activities of macrophages. PMID: 22470185
    21. This review demonstrated that class A SR and MARCO are major pattern recognition receptors mediating opsonin-independent phagocytosis. PMID: 22470186
    22. genetic variants in MARCO gene were associated with pulmonary tuberculosis susceptibility in Chinese Han population PMID: 21886847
    23. These results demonstrate that the S. mutans lipoprotein PpiA contributes to suppression of MARCO-mediated phagocytosis of this bacterium by macrophages. PMID: 21986627
    24. Data suggest that bacteria induce glial cell activation and rCRAMP expression via FPRL1 and MARCO, and these receptors contribute to the host defence against infection. PMID: 21299846
    25. MARCO is an important phagocytic receptor used by human and mouse macrophages to clear C. sordellii from the infected uterus PMID: 20810988
    26. An arginine-rich segment in domain V of MARCO and particularly its RXR motifs play a critical role in high-affinity bacterial binding. PMID: 11820786
    27. characterization of a MARCO protein domain involved in binding to bacteria PMID: 12097327
    28. Northern blot and in situ hybridization experiments indicate that MARCO is expressed by alveolar macrophages in the lung; retroviral vector-mediated expression cloning determines that MARCO is a receptor for UGRP1. PMID: 12847263
    29. a dominant role for MARCO in the human AM defense against inhaled particles and pathogens. PMID: 16237101
    30. Expansion of small sputum macrophages in cystic fibrosis shows a failure to express MARCO and CD206. PMID: 19403625

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  • 亞細胞定位：
    Cell membrane; Single-pass type II membrane protein.
  • 組織特異性：
    Expressed in alveolar macrophages (at protein level). Detected in macrophages from various tissues including thymus, kidney, Kupffer cells of liver, and spleen.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6895

    OMIM: 604870

    KEGG: hsa:8685

    STRING: 9606.ENSP00000318916

    UniGene: Hs.67726



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