日本高潮视频在线观看-亚洲中文字幕永不卡-精品亚洲一区二区三区-伦理片夜夜躁狠狠躁日日躁-日本最新免费不卡二区-国产精品口爆一区二区三区-av一区二区三区高清-大鸡巴疯狂抽插小穴视频-日韩中文国产在线观看免费视频

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 科研級(jí)生物類似抗體
  4. LTBR (US7429644B2 Biosimilar) Recombinant Monoclonal Antibody

LTBR (US7429644B2 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA013227MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    LTBR (US7429644B2 Biosimilar Antibody) 重組單克隆抗體是一種針對(duì)淋巴毒素β受體（LTβR），其源于重組人LTBR蛋白，主要與人源LTβR發(fā)生特異性反應(yīng)。該抗體的靶點(diǎn)LTβR，又稱CD18抗體、TNFRSF3抗體等，屬于腫瘤壞死因子受體超家族成員3（TNFR superfamily member 3），在免疫調(diào)節(jié)、炎癥反應(yīng)及淋巴組織發(fā)育中具有重要作用。 針對(duì)LTβR的靶向藥物的作用機(jī)制與LTβR信號(hào)通路相關(guān)。LTβR在多種免疫細(xì)胞及腫瘤微環(huán)境中高表達(dá)，其介導(dǎo)的信號(hào)參與淋巴細(xì)胞募集、生發(fā)中心形成及炎癥因子釋放。目前，針對(duì)LTβR的靶向治療藥物主要應(yīng)用于自身免疫性疾?。ㄈ珙愶L(fēng)濕關(guān)節(jié)炎、炎癥性腸?。┖蛺盒阅[瘤（如淋巴瘤、實(shí)體瘤）。臨床研究顯示，相關(guān)藥物可通過阻斷LTβR-LTβ相互作用，抑制炎癥級(jí)聯(lián)反應(yīng)或腫瘤血管生成，為相關(guān)疾病提供治療策略。此外，作為其的工具，其研發(fā)旨在降低藥物發(fā)現(xiàn)的陽性對(duì)照成本，提升患者用藥可及性，相關(guān)藥物目前正處于臨床試驗(yàn)階段，評(píng)估其療效與安全性。 LTBR重組單克隆抗體廣泛應(yīng)用于基礎(chǔ)免疫學(xué)與分子生物學(xué)研究。由于其與人源LTβR的高度特異性結(jié)合能力，助力解析LTβR在免疫細(xì)胞分化、組織穩(wěn)態(tài)維持中的分子機(jī)制。例如，通過中和LTβR信號(hào)，研究者可探索其在淋巴器官發(fā)育缺陷模型中的作用；在腫瘤研究中，該抗體可用于驗(yàn)證LTβR作為治療靶點(diǎn)的可行性，或聯(lián)合免疫檢查點(diǎn)抑制劑增強(qiáng)抗腫瘤免疫應(yīng)答。其多別名特性提示，在實(shí)驗(yàn)設(shè)計(jì)中需注意靶點(diǎn)名稱的統(tǒng)一標(biāo)注，避免混淆。 綜上，LTBR重組單克隆抗體不僅為臨床疾病治療提供了新工具，也為深入探索LTβR信號(hào)網(wǎng)絡(luò)的基礎(chǔ)研究奠定了基礎(chǔ)，具有重要的轉(zhuǎn)化醫(yī)學(xué)價(jià)值。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CD18 antibody; D12S370 antibody; LT beta R antibody; LTBETAR antibody; Ltbr antibody; Lymphotoxin B receptor antibody; Lymphotoxin beta receptor；TNFR superfamily; member 3 antibody; Lymphotoxin beta receptor antibody; Lymphotoxin-beta receptor antibody; TNF R III antibody; TNF-RIII antibody; TNFCR antibody; TNFR RP antibody; TNFR superfamily member 3 antibody; TNFR-III antibody; TNFR2 RP antibody; TNFR2RP antibody; TNFR3 antibody; TNFRII antibody; TNFRRP antibody; TNFRSF 3 antibody; TNFRSF3 antibody; TNR3_HUMAN antibody; Tumor necrosis factor C receptor antibody; Tumor necrosis factor receptor 2 related protein antibody; Tumor necrosis factor receptor 2-related protein antibody; Tumor necrosis factor receptor superfamily member 3 antibody; Tumor necrosis factor receptor superfamily member 3 precursor antibody; Tumor necrosis factor receptor type III antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human LTBR protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. Promotes apoptosis via TRAF3 and TRAF5. May play a role in the development of lymphoid organs.
  • 基因功能參考文獻(xiàn)：
    1. the lymphotoxin beta receptor (LTbetaR) to elicit the fast release of NF-kappaB inducing kinase (NIK) from the receptor complex leading to non-canonical NF-kappaB signaling. PMID: 29329668
    2. these results suggest that the LTBR rs12354 polymorphism might be associated with the spontaneous resolution of hepatitis B virus infection PMID: 28575727
    3. LTBR and BCLAF1 showed higher DNA methylation percentages in the marsupialized OKCs, but this difference did not affect gene expression (P > .05). PMID: 28864293
    4. membrane-bound lymphotoxin-beta receptor (LTbetaR) and CXC chemokine receptor 2 (CXCR2), is involved in type B EAE development PMID: 27820602
    5. LIGHT and LTBR interaction increases the survival and proliferation of human bone marrow-derived mesenchymal stem cells, and therefore, LIGHT might play an important role in stem cell therapy. PMID: 27835685
    6. We found that LTbetaR polymorphisms caused severe BPH. Thus, LTbetaR may contribute to the risk of BPH development. PMID: 26782510
    7. activation enhances the LPS-induced expression of IL-8 through NF-kappaB and IRF-1 PMID: 25887375
    8. LIGHT, via LTbetaR signaling, may contribute to exacerbation of airway neutrophilic inflammation through cytokine and chemokine production by bronchial epithelial cells. PMID: 25501580
    9. Relative expression of HVEM and LTbetaR modulates canonical NF-kappaB and pro-apoptotic signals stimulated by LIGHT. PMID: 24980868
    10. lymphotoxin-B-specific receptor. PMID: 24563505
    11. Dimerization of LTbetaR by LTalpha1beta2 is necessary and sufficient for signal transduction. PMID: 24248355
    12. Results suggest that blockade of lymphotoxin-beta receptor (LTBR) pathways may have therapeutic potential for treatment of Sjogren's syndrome. PMID: 22044682
    13. LTBR gene polymorphisms may be associated with risk of IgA nephropathy in Korean children PMID: 22417320
    14. show that a cognate interaction between LTalphabeta on CD4(+) helper T cells and LTbeta receptor on DCs results in unique signals that are necessary for optimal CD8(+) T-cell expansion via a type I IFN-dependent mechanism PMID: 21245292
    15. These results indicated that AdipoR1 interacted with LTBR and mediated the inhibition of LTBR-activated NF-kappaB pathway. PMID: 21195057
    16. LTbetaR levels are independently associated with atherosclerosis in multiple vascular beds PMID: 20599198
    17. Increased potential for LTbeta receptor signaling, coupled with increased bioavailability due to lower decoy receptor-3 (DcR3) avidity, provides a mechanism for polymorphic variants in LIGHT to contribute to the pathogenesis of inflammatory diseases. PMID: 20592286
    18. the LTbetaR modifies the ubiquitin:NIK E3 ligase, and also acts as an allosteric regulator of the ubiquitin:TRAF E3 ligase PMID: 20348096
    19. Modulation of cellular TRAF3 levels may thus contribute to regulation of NFkappaB-dependent gene expression by LTBR by affecting the balance of LTBR-dependent activation of canonical and non-canonical NFkappaB pathways. PMID: 20185819
    20. Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation.(AP-1) PMID: 12169272
    21. The NF-kappa B activation in lymphotoxin beta receptor signaling depends on the phosphorylation of p65 at serine 536. PMID: 12419817
    22. Data show that mRNA encoding LIGHT and its receptors [HVEM, LTbetaR, and TR6 (DcR3)] are present in placentas and cytotrophoblast cells at term. PMID: 12466117
    23. GA-binding protein (GABP) and Sp1 and retinoid receptors are required to mediate retinoic acid responsiveness of CD18 transcriptional activation in myeloid cells. PMID: 12485937
    24. ASK1 is one of the factors involved in the caspase-independent pathway of LTbetaR-induced cell death. PMID: 12566458
    25. TRAF2, TRAF3, cIAP1, Smac, and lymphotoxin beta receptor associate and are involved in apoptosis PMID: 12571250
    26. LTbetaR, CD40 and TANK interact with TRAF3 at sites that promote molecular interactions driving specific signaling PMID: 14517219
    27. both LTbetaR and HVEM can discriminatively mediate the expression of different genes in cultured human umbilical vein endothelial cells, including LIGHT, a proinflammatory cytokine PMID: 15917993
    28. Signaling through the lymphotoxin beta receptor (LTbetaR) expressed on mature hepatocytes induces massive hepatomegaly; LTbetaR and its ligands define a new pathway in supporting liver regeneration PMID: 16002734
    29. Blockade of TNFSF14 signaling caused a substantial reduction in the expression of lymphotoxin beta receptor (LTbetaR)-controlled migration factors within the islets and disrupts organization of tertiary structures, leading to prevention of diabetes. PMID: 16934497
    30. membrane-bound receptor that mediates apoptosis (LTbetaR) was present in syncytiotrophoblast and cytotrophoblast cells in all samples but were detected in placental stromal cells only at week 8 and thereafter PMID: 17010447
    31. Evidence in this review indicates that double positive-thymocytes regulate the differentiation of early thymocyte progenitors and gamma delta T cells through a mechanism dependent on LT beta receptor. PMID: 17336158
    32. These results define a model for the study of inflammatory lymphangiogenesis in the thyroid and implicate lymphotoxin beta receptor signaling in this process. PMID: 17360402
    33. This review discusses recent studies indicating that LT beta R signaling is required for liver regeneration, hepatitis, and hepatic lipid metabolism. PMID: 17896993
    34. Lymphotoxin beta receptor ligation directly activates gene expression in human vascular endothelial cells via both noncanonical and classical NF-kappa B pathways. PMID: 18292573
    35. LTbeta-R constitutively induces NF-kappaB activation, and this event may be associated with autonomous growth of melanoma cells. PMID: 18347013
    36. lymphotoxin beta receptor (LTbetaR) was detected in Rheumatoid arthritis fibroblast-like synoviocytes PMID: 18412315

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6718

    OMIM: 600979

    KEGG: hsa:4055

    STRING: 9606.ENSP00000228918

    UniGene: Hs.1116



×
生命科學(xué)計(jì)算平臺(tái)