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  4. LILRB2 (MK-4830 Biosimilar) Recombinant Monoclonal Antibody

LILRB2 (MK-4830 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA839793MB5HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    LILRB2 (MK-4830 Biosimilar Antibody)重組單克隆抗體是一種用于科研領(lǐng)域的生物試劑，專為靶向LILRB2（白細(xì)胞免疫球蛋白樣受體B2）設(shè)計。該抗體通過重組DNA技術(shù)制備，具有高特異性和親和力，能夠精準(zhǔn)識別并結(jié)合LILRB2蛋白，為相關(guān)研究提供可靠的分子工具。 LILRB2作為免疫調(diào)節(jié)受體家族成員，在免疫細(xì)胞活化、炎癥反應(yīng)及腫瘤微環(huán)境調(diào)控中發(fā)揮重要作用。本產(chǎn)品可用于探索LILRB2在免疫調(diào)節(jié)通路中的分子機制，包括其與配體的相互作用、信號轉(zhuǎn)導(dǎo)途徑及生理病理功能。研究人員可借助該抗體開展細(xì)胞水平的結(jié)合實驗、分析等多種實驗，深入揭示LILRB2在疾病發(fā)生發(fā)展中的作用。 該重組單克隆抗體采用嚴(yán)格的生產(chǎn)工藝，確保批次間的一致性和高純度。其性能經(jīng)過多項質(zhì)量控制檢測，包括抗體活性、特異性、內(nèi)毒素含量及穩(wěn)定性驗證，適用于體外細(xì)胞培養(yǎng)、動物模型研究等多種科研場景。通過特異性阻斷或激活LILRB2信號，可助力開發(fā)基于免疫調(diào)節(jié)的新型治療策略研究，為免疫相關(guān)疾病及腫瘤領(lǐng)域的基礎(chǔ)研究提供有力支持。 本產(chǎn)品僅供科研使用，旨在推動LILRB2相關(guān)分子機制的研究進展，為生命科學(xué)領(lǐng)域的探索提供高質(zhì)量的實驗材料。
  • Uniprot No.：
  • 基因名：
  • 別名：
    MK4830 research-grade biosimilar; MK 4830 research-grade biosimilar ;LILRB2 antibody; ILT4 antibody; LIR2 antibody; MIR10 antibody; Leukocyte immunoglobulin-like receptor subfamily B member 2 antibody; LIR-2 antibody; Leukocyte immunoglobulin-like receptor 2 antibody; CD85 antigen-like family member D antibody; Immunoglobulin-like transcript 4 antibody; ILT-4 antibody; Monocyte/macrophage immunoglobulin-like receptor 10 antibody; MIR-10 antibody; CD antigen CD85d antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human LILRB2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed in monocytes and at lower levels in myeloid and plasmacytoid dendritic cells. Expressed in tolerogenic IL10-producing dendritic cells. Expressed in myeloid-derived suppressor cells during pregnancy. Detected at low levels in natural killer (NK)
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6606

    OMIM: 604815

    STRING: 9606.ENSP00000375629

    UniGene: Hs.655652



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