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  4. LILRB2 (ES-009 Biosimilar) Recombinant Monoclonal Antibody

LILRB2 (ES-009 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA839793MB3HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    LILRB2 (ES-009 Biosimilar Antibody)重組單克隆抗體是一款專為科研用途開發(fā)的生物試劑，旨在為生命科學研究提供高質(zhì)量的靶向工具。該抗體以白細胞免疫球蛋白樣受體B2（LILRB2）為特異性靶點，通過重組DNA技術(shù)在哺乳動物細胞表達系統(tǒng)中制備，確保了產(chǎn)物的高純度、高活性及批次間的穩(wěn)定性。 作為免疫球蛋白超家族成員，LILRB2在免疫調(diào)節(jié)、炎癥反應及腫瘤微環(huán)境調(diào)控中發(fā)揮重要作用。本產(chǎn)品通過精準識別LILRB2胞外結(jié)構(gòu)域，可應用于多種實驗場景：包括但不限于分析細胞表面受體表達、/檢測組織樣本中的LILRB2分布、探究蛋白相互作用，以及基于細胞模型的功能學研究。 該抗體經(jīng)嚴格的質(zhì)量控制流程驗證，包括SDS-PAGE純度分析（純度≥95%）、ELISA效價測定、流式細胞結(jié)合活性檢測及內(nèi)毒素水平控制（<0.1 EU/μg），確保滿足科研實驗的嚴苛要求。產(chǎn)品提供凍干粉形式，便于長期保存（-20℃可穩(wěn)定保存2年），復溶后可在4℃短期存放，操作便捷。 作為科研專用試劑，LILRB2 (ES-009 Biosimilar Antibody)重組單克隆抗體為深入探索LILRB2在免疫調(diào)控、疾病發(fā)生機制中的作用提供了可靠工具，適用于免疫學、腫瘤生物學、神經(jīng)科學等多個研究領域，助力科研人員揭示相關生理病理過程的分子機制。
  • Uniprot No.：
  • 基因名：
  • 別名：
    ES009 research-grade biosimilar; ES 009 research-grade biosimilar ;LILRB2 antibody; ILT4 antibody; LIR2 antibody; MIR10 antibody; Leukocyte immunoglobulin-like receptor subfamily B member 2 antibody; LIR-2 antibody; Leukocyte immunoglobulin-like receptor 2 antibody; CD85 antigen-like family member D antibody; Immunoglobulin-like transcript 4 antibody; ILT-4 antibody; Monocyte/macrophage immunoglobulin-like receptor 10 antibody; MIR-10 antibody; CD antigen CD85d antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human LILRB2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed in monocytes and at lower levels in myeloid and plasmacytoid dendritic cells. Expressed in tolerogenic IL10-producing dendritic cells. Expressed in myeloid-derived suppressor cells during pregnancy. Detected at low levels in natural killer (NK)
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6606

    OMIM: 604815

    STRING: 9606.ENSP00000375629

    UniGene: Hs.655652



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