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  4. LILRB2 (CHS-1000 Biosimilar) Recombinant Monoclonal Antibody

LILRB2 (CHS-1000 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA839793MB2HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    LILRB2 (CHS-1000 Biosimilar Antibody)重組單克隆抗體是一款專為科研用途開發(fā)的生物試劑，旨在助力免疫調(diào)節(jié)機(jī)制及相關(guān)疾病研究。該抗體靶向白細(xì)胞免疫球蛋白樣受體B2（LILRB2），通過高特異性識(shí)別與結(jié)合該受體，為探索其在免疫抑制、炎癥反應(yīng)及腫瘤微環(huán)境調(diào)控中的作用提供關(guān)鍵工具。 本產(chǎn)品采用重組DNA技術(shù)制備，經(jīng)嚴(yán)格的質(zhì)量控制確保批次間一致性與高純度。其抗原結(jié)合片段（Fab）可精準(zhǔn)識(shí)別LILRB2胞外結(jié)構(gòu)域，支持多種實(shí)驗(yàn)應(yīng)用，適用于細(xì)胞水平的受體表達(dá)分析、信號(hào)通路研究及受體-配體相互作用機(jī)制探討。 在科研場(chǎng)景中，該抗體可用于驗(yàn)證LILRB2在巨噬細(xì)胞、樹突狀細(xì)胞等免疫細(xì)胞中的表達(dá)模式，揭示其在腫瘤免疫逃逸中的調(diào)控作用，或助力自身免疫性疾病的分子機(jī)制研究。其高度靶向性減少了非特異性結(jié)合干擾，為獲取可靠實(shí)驗(yàn)數(shù)據(jù)提供保障。 產(chǎn)品嚴(yán)格限定于實(shí)驗(yàn)室研究使用，不用于臨床診斷或治療。使用時(shí)需結(jié)合相關(guān)陽(yáng)性對(duì)照與實(shí)驗(yàn)方案優(yōu)化，以確保研究結(jié)果的科學(xué)性與可重復(fù)性。通過提供特異性分子工具，該抗體為深入解析LILRB2介導(dǎo)的免疫調(diào)節(jié)網(wǎng)絡(luò)及開發(fā)潛在治療靶點(diǎn)奠定基礎(chǔ)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CHS 1000 research-grade biosimilar; CHS-1000 research-grade biosimilar ;LILRB2 antibody; ILT4 antibody; LIR2 antibody; MIR10 antibody; Leukocyte immunoglobulin-like receptor subfamily B member 2 antibody; LIR-2 antibody; Leukocyte immunoglobulin-like receptor 2 antibody; CD85 antigen-like family member D antibody; Immunoglobulin-like transcript 4 antibody; ILT-4 antibody; Monocyte/macrophage immunoglobulin-like receptor 10 antibody; MIR-10 antibody; CD antigen CD85d antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human LILRB2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed in monocytes and at lower levels in myeloid and plasmacytoid dendritic cells. Expressed in tolerogenic IL10-producing dendritic cells. Expressed in myeloid-derived suppressor cells during pregnancy. Detected at low levels in natural killer (NK)
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6606

    OMIM: 604815

    STRING: 9606.ENSP00000375629

    UniGene: Hs.655652



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