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  4. LILRA4 (daxdilimab Biosimilar) Recombinant Monoclonal Antibody

LILRA4 (daxdilimab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA012936MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    LILRA4（daxdilimab Biosimilar Antibody）重組單克隆抗體是一種針對(duì)白細(xì)胞免疫球蛋白樣受體亞家族A成員4（LILRA4），其別名為CD85抗原樣家族成員G抗體、CD85g抗體、ILT-7抗體、ILT7抗體、免疫球蛋白樣轉(zhuǎn)錄物7抗體、LILRA4抗體、LIRA4_HUMAN抗體、MGC129597抗體及MGC129598抗體等。該抗體以重組人LILRA4蛋白制備，具有高度的種屬反應(yīng)性，主要針對(duì)人類LILRA4蛋白發(fā)揮特異性結(jié)合作用。 daxdilimab Biosimilar Antibody作為靶向LILRA4抗體，daxdilimab類似物，可通過(guò)調(diào)節(jié)免疫細(xì)胞活性為相關(guān)疾病治療提供新策略。目前其臨床研究聚焦于自身免疫性疾病（如系統(tǒng)性紅斑狼瘡、類風(fēng)濕關(guān)節(jié)炎）及惡性腫瘤（如血液系統(tǒng)腫瘤、實(shí)體瘤），旨在通過(guò)阻斷或激活LILRA4信號(hào)通路，恢復(fù)免疫平衡或增強(qiáng)抗腫瘤免疫應(yīng)答。 LILRA4重組單克隆抗體是探究LILRA4生物學(xué)功能的重要工具。研究人員可利用該抗體進(jìn)行實(shí)驗(yàn)，分析LILRA4在不同組織、細(xì)胞中的表達(dá)分布及亞細(xì)胞定位；通過(guò)免疫共沉淀、pull-down等技術(shù)研究其與配體或信號(hào)分子的相互作用；還可構(gòu)建LILRA4敲除或過(guò)表達(dá)細(xì)胞模型，結(jié)合抗體干預(yù)實(shí)驗(yàn)，深入揭示其在免疫調(diào)控、炎癥反應(yīng)及腫瘤發(fā)生發(fā)展中的分子機(jī)制，為開(kāi)發(fā)基于LILRA4的靶向治療藥物奠定實(shí)驗(yàn)基礎(chǔ)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CD85 antigen-like family member G antibody; CD85g antibody; ILT-7 antibody; ILT7 antibody; Immunoglobulin like transcript 7 antibody; Immunoglobulin-like transcript 7 antibody; Leukocyte immunoglobulin-like receptor subfamily A member 4 antibody; LILRA4 antibody; LIRA4_HUMAN antibody; MGC129597 antibody; MGC129598 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human LILRA4 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Functions coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells.
  • 基因功能參考文獻(xiàn)：
    1. Crosslinked ILT7 favours the differentiation of immature plasmacytoid dendritic cells into antigen-presenting cells rather than IPC. PMID: 24586760
    2. ILT7 may exert its immunomodulatory activity only on immature circulating plasmacytoid dendritic cells (pDCs), providing a basic homeostatic mechanism rather than negative feedback control on activated pDCs. PMID: 23401591
    3. Intracellular expression of the TCL1 as well as membrane and intracellular expression of ILT7 in plasmacytoid dendritic cell leukemia (pDCL) samples and 61 non-pDC acute leukemia samples, were tested. PMID: 22674796
    4. the expression of immunoglobulin-like transcript 7, in plasmacytoid dendritic cells PMID: 12384430
    5. ILT7 protein associates with the signal adapter protein Fc epsilonRI gamma to form a receptor complex in dendritic cells. PMID: 16735691
    6. key regulator of human pDC function and interferon type I production. PMID: 18048391
    7. Data show that BST2 directly binds to purified ILT7, initiates signaling via the ILT7-FcepsilonRIgamma complex, and regulates TLR7/9 responses in plasmacytoid dendritic cells. PMID: 19564354

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Detected on plasmacytoid dendritic cells (at protein level). Detected on plasmacytoid dendritic cells, but not on monocytes or B cells.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 15503

    OMIM: 607517

    KEGG: hsa:23547

    STRING: 9606.ENSP00000291759

    UniGene: Hs.406708



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