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  4. KLKB1 (Navenibart Biosimilar) Recombinant Monoclonal Antibody

KLKB1 (Navenibart Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA012461MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    KLKB1 (Navenibart Biosimilar Antibody)重組單克隆抗體是一種用于科研領(lǐng)域的生物制劑，通過重組DNA技術(shù)在實(shí)驗(yàn)室環(huán)境中制備而成。該抗體具有高度特異性的靶向結(jié)合能力，能夠精準(zhǔn)識別并結(jié)合特定的生物分子靶點(diǎn)，為生命科學(xué)研究提供重要工具。 在科研應(yīng)用中，KLKB1 (Navenibart Biosimilar Antibody)重組單克隆抗體可廣泛用于蛋白質(zhì)檢測、細(xì)胞定位、信號通路分析某些實(shí)驗(yàn)場景。其高度均一的分子結(jié)構(gòu)和穩(wěn)定的生物學(xué)活性，有助于提高實(shí)驗(yàn)結(jié)果的可重復(fù)性和可靠性，支持研究者在基礎(chǔ)醫(yī)學(xué)、分子生物學(xué)、細(xì)胞生物學(xué)等領(lǐng)域開展深入研究。 該抗體采用先進(jìn)的重組表達(dá)系統(tǒng)生產(chǎn)，經(jīng)過嚴(yán)格的質(zhì)量控制流程，確保產(chǎn)品純度和活性符合科研實(shí)驗(yàn)的嚴(yán)格要求。通過特異性結(jié)合靶點(diǎn)，KLKB1 (Navenibart Biosimilar Antibody)重組單克隆抗體能夠幫助科研人員探索生物分子的功能機(jī)制、疾病相關(guān)通路的調(diào)控規(guī)律，為疾病的基礎(chǔ)研究和潛在治療策略的開發(fā)提供實(shí)驗(yàn)依據(jù)。 作為科研用試劑，KLKB1 (Navenibart Biosimilar Antibody)重組單克隆抗體為生命科學(xué)領(lǐng)域的創(chuàng)新研究提供了有力支持，推動(dòng)相關(guān)領(lǐng)域的學(xué)術(shù)探索和技術(shù)發(fā)展。其應(yīng)用范圍涵蓋等多種實(shí)驗(yàn)技術(shù)，滿足不同研究方向的需求，助力科研人員取得高質(zhì)量的研究成果。
  • Uniprot No.：
  • 基因名：
  • 別名：
    QLS-215 research-grade biosimilar; STAR 0215 research-grade biosimilar; STAR-0215 research-grade biosimilar ;KLKB1 antibody; KLK3 antibody; Plasma kallikrein antibody; EC 3.4.21.34 antibody; Fletcher factor antibody; Kininogenin antibody; Plasma prekallikrein antibody; PKK [Cleaved into: Plasma kallikrein heavy chain antibody; Plasma kallikrein light chain] antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human KLKB1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
  • 基因功能參考文獻(xiàn)：
    1. We further define the interactions of keratinocyte PKK with TP63 and NF-kappaB signaling, highlighting the importance of this protein as a tumor suppressor in skin squamous cell carcinoma development. PMID: 29186361
    2. Plasma kallikrein (PLK)-dependent transforming growth factor-beta (TGF-beta) activation could be detected in isolated pancreatic stellate cells (PSCs) from chronic pancreatitis (CP) and pancreatic cancer. PMID: 28187111
    3. High molecular weight kinin functions as a cofactor for PK activation in the presence of nucleic acids in a manner consistent with classic models of contact activation. PMID: 28124063
    4. genetic polymorphism is associated with C1 Inhibitor deficiency angioedema age of onset in European families PMID: 29130992
    5. these data indicate that KLKB1 induces inflammatory reactions in human dental tissues via protease-activated receptor 1 PMID: 26566265
    6. von Willebrand factor activity and concentration of prekallikrein may both be of importance regarding the evolution of thrombus in abdominal aortic aneurysm and possible biomarkers for aneurysm growth. PMID: 27581227
    7. KLKB1 mRNA expression is a putative molecular biomarker in chronic lymphocytic leukemia. PMID: 25891023
    8. Genotyping these subjects revealed that the carriers of the minor alleles at the two loci- F12 and KLKB1 had a significant association with reduced levels of active plasma renin. PMID: 26969407
    9. 2 genetic loci (kininogen 1 and kallikrein B) influencing key components of the RAAS, consistent with the close interrelation between the kallikrein-kinin system and the RAAS. PMID: 25477429
    10. PRCP1 interacts with plasma kallikrein (PK) at multiple sites for PK activation. PMID: 25324000
    11. Prekallikrein deficiency in a family is due to a new mutation (Arg541Gln) in exon 14. PMID: 25075649
    12. FXI may have a role in risk of ischemic stroke, but not myocardial infarct; FXII and prekallikrein may not have a role in either PMID: 24977287
    13. The acquisition of an active site in prekallikrein as a result of binding to high-molecular-weight kininogen (HK) is a new concept for bradykinin formation and might be relevant in the pathogenesis of hereditary angiodema types I and II. PMID: 23672780
    14. Investigate the relationship between circulating PK levels in children with metabolic syndrome and CVD risk factors because PK may be involved in the progression of the disease state. PMID: 20725119
    15. Case Report: Fresh frozen plasma transfusion before coronary artery bypass corrects prekallikrein deficiency. PMID: 20135073
    16. plasma kallikrein and FXIa activate pro-HGF in vitro PMID: 12372819
    17. the effect of kininogen degradation by human neutrophil elastase (HNE) on kinin generation by tissue and plasma kallikreins. PMID: 12887060
    18. prekallikrein preferential binding to endothelial cells contributes to their anticoagulant nature PMID: 12944405
    19. Crystallization and x-ray crystal structure determination have yielded the first three-dimensional views of the catalytic domain of plasma kallikrein PMID: 16199530
    20. Our findings suggested that common genetic variation in the KLKB1 gene might contribute to the risk of hypertension in the northern Han Chinese population. PMID: 17318641
    21. study demonstrates by immunohistochemistry that plasma kallikrein (PK) is localised in cells of different embryologically derived human tissues PMID: 17696780
    22. three-dimensional structural data for prekallikrein (PK); interaction between PK and high-molecular-weight kininogen is mediated by two discrete surfaces formed by the PK A1, A2 and A4 domains with charge likely to be a critical component of the binding PMID: 17922805
    23. Kallikrein can directly activate prothrombin; there is a shortcut in the intrinsic hemostasis system that generates catalytic amounts of thrombin without following the known intrinsic clotting pathway PMID: 18160576
    24. Kallikrein is responsible for the cleavage of factor H. PMID: 18413232
    25. prekallikrein is an enzyme that can cleave high-molecular-weight kininogen to release bradykinin, and this reaction is inhibited by C1 inhibitor. PMID: 19342086
    26. NPY3-35 is a new peptide generated by plasma kallikrein PMID: 19620246

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  • 相關(guān)疾?。?/div>
    Prekallikrein deficiency (PKK deficiency)
  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    Peptidase S1 family, Plasma kallikrein subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6371

    OMIM: 229000

    KEGG: hsa:3818

    STRING: 9606.ENSP00000264690

    UniGene: Hs.237642



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