ILDR2 (Bapotulimab Biosimilar) Recombinant Monoclonal Antibody
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貨號(hào):CSB-RA751251MB1HU
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規(guī)格:¥83486
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:ILDR2(Bapotulimab Biosimilar Antibody)重組單克隆抗體是一種針對(duì)免疫球蛋白樣結(jié)構(gòu)域包含受體2(ILDR2,別名C1orf32)。該抗體以重組人ILDR2蛋白制備研發(fā),具有高度的種屬反應(yīng)性,主要適用于人類(lèi)樣本的研究與應(yīng)用。ILDR2作為一種跨膜蛋白,在免疫調(diào)節(jié)、細(xì)胞信號(hào)傳導(dǎo)等生理過(guò)程中可能發(fā)揮重要作用,其異常表達(dá)與多種疾病的發(fā)生發(fā)展密切相關(guān),因此成為生物醫(yī)藥領(lǐng)域的研究熱點(diǎn)。 Bapotulimab藥物的開(kāi)發(fā)為相關(guān)疾病的治療提供了新方向。目前,針對(duì)Bapotulimab的臨床研究顯示其可能用于自身免疫性疾病、腫瘤等疾病的治療,例如在某些腫瘤治療中,Bapotulimab可能通過(guò)影響免疫細(xì)胞的浸潤(rùn)和抗腫瘤免疫應(yīng)答發(fā)揮作用。作為生物類(lèi)似藥,Bapotulimab在臨床應(yīng)用前需通過(guò)嚴(yán)格的比對(duì)分析,確保其與原研藥在分子結(jié)構(gòu)、生物學(xué)活性、安全性和有效性方面高度相似,為臨床應(yīng)用奠定基礎(chǔ)。未來(lái),其價(jià)值可能體現(xiàn)在靶向ILDR2的免疫治療、疾病診斷標(biāo)志物等方面,為疾病的精準(zhǔn)治療提供新策略。 ILDR2重組單克隆抗體是探索ILDR2功能的重要工具。因其對(duì)人類(lèi)ILDR2的特異性識(shí)別能力,助力研究人員分析ILDR2在不同組織、細(xì)胞中的表達(dá)定位及水平變化。此外,該抗體還可用于體外功能實(shí)驗(yàn),如通過(guò)中和ILDR2活性或激活其信號(hào)通路,深入探究其在細(xì)胞增殖、分化、凋亡等過(guò)程中的作用機(jī)制。在疾病模型研究中,ILDR2抗體有助于構(gòu)建更貼近人類(lèi)病理生理狀態(tài)的實(shí)驗(yàn)?zāi)P?,為揭示疾病發(fā)病機(jī)制、篩選潛在治療靶點(diǎn)提供關(guān)鍵支持,推動(dòng)相關(guān)領(lǐng)域的基礎(chǔ)研究向臨床轉(zhuǎn)化。
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Uniprot No.:
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基因名:
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別名:ILDR2; C1orf32Immunoglobulin-like domain-containing receptor 2
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反應(yīng)種屬:Human
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免疫原:Recombinant Human ILDR2 protein
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免疫原種屬:Homo sapiens (Human)
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標(biāo)記方式:Non-conjugated
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克隆類(lèi)型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產(chǎn)品提供形式:Liquid
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應(yīng)用說(shuō)明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲(chǔ)存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:In stock
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
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靶點(diǎn)詳情
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功能:May be involved in lipid homeostasis and ER stress pathways.
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基因功能參考文獻(xiàn):
- We demonstrated that ZNF70 interacts with ZFP64 and activates HES1 transcription by binding to the HES1 promoter. In addition, HES1 gene expression is increased in ILDR2-knockdown HepG2 cells, in which ZNF70 is translocated from the cytoplasm to the nucleus, suggesting that ZNF70 migration to the nucleus after dissociating from the ILDR2-ZNF70 complex activates HES1 transcription. These results support a novel link betwee PMID: 27353377
- Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19536175
- Observational study of gene-disease association. (HuGE Navigator) PMID: 19064610
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亞細(xì)胞定位:Endoplasmic reticulum membrane; Single-pass type I membrane protein.
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蛋白家族:Immunoglobulin superfamily, LISCH7 family
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數(shù)據(jù)庫(kù)鏈接:
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