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  4. ILDR2 (BAY-1905254 Biosimilar) Recombinant Monoclonal Antibody

ILDR2 (BAY-1905254 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA751251MB2HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    ILDR2 (BAY-1905254 Biosimilar Antibody)重組單克隆抗體是一款用于生命科學(xué)研究的生物試劑，通過基因工程技術(shù)在哺乳動物細胞中表達制備，具有高純度、高特異性和批次間一致性的特點。該抗體針對ILDR2靶點設(shè)計，可特異性識別并結(jié)合ILDR2蛋白，為研究其在生理和病理過程中的功能提供重要工具。 ILDR2作為一種跨膜蛋白，在細胞黏附、信號轉(zhuǎn)導(dǎo)及組織發(fā)育等生物學(xué)過程中發(fā)揮關(guān)鍵作用。本產(chǎn)品適用于多種實驗場景，包括、及ELISA等，助力科研人員深入探究ILDR2相關(guān)的分子機制和疾病關(guān)聯(lián)。 該重組單克隆抗體經(jīng)過嚴格的質(zhì)量控制，確保低內(nèi)毒素水平和高親和力，可有效降低實驗背景干擾。其凍干粉劑型便于長期保存，復(fù)溶后穩(wěn)定性良好，適合長期實驗研究使用。通過特異性結(jié)合ILDR2，本產(chǎn)品為揭示其在腫瘤發(fā)生、神經(jīng)退行性疾病及免疫調(diào)控等領(lǐng)域的作用機制提供可靠支持，是生命科學(xué)基礎(chǔ)研究及藥物靶點發(fā)現(xiàn)的重要工具。 產(chǎn)品使用前需按照說明書進行復(fù)溶和稀釋，具體實驗條件可根據(jù)不同研究需求進行優(yōu)化。建議在-20℃條件下避光保存，避免反復(fù)凍融以保證抗體活性。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Bapotulimab research-grade biosimilar; CGEN-15001T program research-grade biosimilar; CGEN-15001T-targeted mAb research-grade biosimilar; CGEN-15001T-targeted monoclonal antibody research-grade biosimilar ;ILDR2 antibody; C1orf32 antibody; Immunoglobulin-like domain-containing receptor 2 antibody; Angulin-3 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human ILDR2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    May be involved in lipid homeostasis and ER stress pathways.
  • 基因功能參考文獻：
    1. We demonstrated that ZNF70 interacts with ZFP64 and activates HES1 transcription by binding to the HES1 promoter. In addition, HES1 gene expression is increased in ILDR2-knockdown HepG2 cells, in which ZNF70 is translocated from the cytoplasm to the nucleus, suggesting that ZNF70 migration to the nucleus after dissociating from the ILDR2-ZNF70 complex activates HES1 transcription. These results support a novel link betwee PMID: 27353377
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    3. Observational study of gene-disease association. (HuGE Navigator) PMID: 19536175
    4. Observational study of gene-disease association. (HuGE Navigator) PMID: 19064610
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, LISCH7 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18131

    KEGG: hsa:387597

    UniGene: Hs.444835



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