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  4. IL31RA (Nemolizumab Biosimilar) Recombinant Monoclonal Antibody

IL31RA (Nemolizumab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA854162MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    IL31RA(Nemolizumab Biosimilar Antibody)重組單克隆抗體是一種針對(duì)白細(xì)胞介素31受體A（IL31RA）的特異性生物制劑，主要用于生命科學(xué)研究領(lǐng)域。該抗體通過基因工程技術(shù)重組表達(dá)，具有高親和力和靶向性，能夠特異性識(shí)別并結(jié)合IL31RA，從而阻斷IL31/IL31RA信號(hào)通路的激活。 在科研應(yīng)用中，IL31RA重組單克隆抗體可用于探究IL31RA在炎癥反應(yīng)、免疫調(diào)節(jié)及相關(guān)疾病發(fā)生發(fā)展中的作用機(jī)制。研究表明，IL31RA作為IL-31的功能性受體，在特應(yīng)性皮炎、過敏性疾病等炎癥性疾病中扮演重要角色。通過使用該抗體，科研人員可深入研究IL31RA介導(dǎo)的信號(hào)轉(zhuǎn)導(dǎo)通路，為理解相關(guān)疾病的病理生理過程提供實(shí)驗(yàn)工具。 該抗體具有高純度、高特異性的特點(diǎn)，適用于多種實(shí)驗(yàn)方法，如及動(dòng)物模型研究等。在體外實(shí)驗(yàn)中，可用于檢測(cè)細(xì)胞表面IL31RA的表達(dá)水平；在體內(nèi)實(shí)驗(yàn)中，可通過抗體干預(yù)探討IL31RA的生物學(xué)功能。其穩(wěn)定的生物學(xué)活性和批次間一致性，能夠?yàn)榭蒲袑?shí)驗(yàn)提供可靠的數(shù)據(jù)支持，助力 IL31RA 相關(guān)機(jī)制研究及潛在治療靶點(diǎn)的發(fā)現(xiàn)。 作為科研用試劑，IL31RA重組單克隆抗體為免疫生物學(xué)、炎癥性疾病機(jī)制等領(lǐng)域的研究提供了重要工具，有助于推動(dòng)相關(guān)基礎(chǔ)研究的進(jìn)展。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Anti-IL-31-receptor-monoclonal-antibody research-grade biosimilar; CD14152 research-grade biosimilar; CD-14152 research-grade biosimilar; CIM331 research-grade biosimilar; CIM-331 research-grade biosimilar; IL-31RA monoclonal antibody research-grade biosimilar; M5250 research-grade biosimilar; M5250B research-grade biosimilar; M5250E research-grade biosimilar; Mitchga research-grade biosimilar; Nemluvio research-grade biosimilar; Nemolizumab research-grade biosimilar; Nemolizumab (Genetical Recombination) research-grade biosimilar; Nemolizumab (genetical recombination) (JAN) research-grade biosimilar; Nemolizumab (INN) research-grade biosimilar; Nemolizumab-ilto research-grade biosimilar ;IL31RA antibody; CRL3 antibody; GPL antibody; UNQ6368/PRO21073/PRO21384 antibody; Interleukin-31 receptor subunit alpha antibody; IL-31 receptor subunit alpha antibody; IL-31R subunit alpha antibody; IL-31R-alpha antibody; IL-31RA antibody; Cytokine receptor-like 3 antibody; GLM-R antibody; hGLM-R antibody; Gp130-like monocyte receptor antibody; Gp130-like receptor antibody; ZcytoR17 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human IL31RA protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1. Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro.
  • 基因功能參考文獻(xiàn)：
    1. The first demonstration of the involvement of the IL-31/IL-31R axis in cancer came from studies in patients with mycosis fungoides/Sezary syndrome, the most frequent, cutaneous T cell lymphoma. Tumor cells were shown to produce IL-31, whose serum levels correlated with pruritus intensity. PMID: 28408397
    2. The interleukin IL-31/IL-31receptor axis contributes to tumor growth in human follicular lymphoma. PMID: 25283844
    3. detected in keratinocytes and nerve fibers in the dermis of atopic dermatitis and in the neurons of normal dorsal root ganglia PMID: 24667097
    4. IL31RA is a functional receptor expressed by a small subpopulation of IL-31RA(+)/TRPV1(+)/TRPA1(+) neurons and is a critical neuroimmune link between TH2 cells and sensory nerves for the generation of T cell-mediated itch. PMID: 24373353
    5. IL-31 and IL-31RA are upregulated in patients with allergic rhinitis, and induce MUC5AC gene expression in human airway epithelial cells. PMID: 23392388
    6. IFN-gamma-induced IL-31RA upregulation in dermal microvascular endothelium is processed via JNK and PI3 kinase activation PMID: 20849534
    7. The identification of OSMR and IL31RA gene pathology provides an explanation of the high prevalence of primary cutaneous amyloidosis in Taiwan as well as new insight into disease pathophysiology. PMID: 19690585
    8. A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5. PMID: 11877449
    9. GPL is a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor PMID: 14504285
    10. the molecular mechanisms underlying GPL-mediated signal transduction PMID: 15194700
    11. IL-31 receptor alpha expression in epidermal keratinocytes is modulated by cell differentiation and interferon gamma PMID: 18580959
    12. ). Binding of IL-31 to its receptor activates Jak/STAT, PI3K/AKT and MAPK pathways.[review] PMID: 18926762

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  • 相關(guān)疾?。?/div>
    Amyloidosis, primary localized cutaneous, 2 (PLCA2)
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, presynaptic cell membrane. Cell projection, axon.
  • 蛋白家族：
    Type I cytokine receptor family, Type 2 subfamily
  • 組織特異性：
    Expressed in CD14- and CD56-positive blood cells. Expressed in macrophages. Expressed in keratinocytes. Expressed in a subset of dorsal root ganglia neurons (at protein level). Expressed at low levels in testis, ovary, brain, prostate, placenta, thymus, b
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18969

    OMIM: 609510

    KEGG: hsa:133396

    STRING: 9606.ENSP00000415900

    UniGene: Hs.55378



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