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IL2RA (dacliximab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào):
    CSB-RA011649MB5HU
  • 規(guī)格:
    ¥83486
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    IL2RA(dacliximab Biosimilar Antibody)重組單克隆抗體是一種針對(duì)白細(xì)胞介素2受體α鏈(IL-2Rα,CD25)的生物制劑。該抗體通過(guò)特異性結(jié)合IL-2Rα,可有效阻斷IL-2介導(dǎo)的信號(hào)通路,從而調(diào)控免疫系統(tǒng)的活化與增殖過(guò)程。作為科研工具,它廣泛應(yīng)用于免疫學(xué)、腫瘤學(xué)及自身免疫性疾病等領(lǐng)域的基礎(chǔ)研究。 在作用機(jī)制方面,IL2RA抗體通過(guò)與T細(xì)胞表面的IL-2Rα高親和力結(jié)合,競(jìng)爭(zhēng)性抑制IL-2與其受體的相互作用,進(jìn)而抑制T細(xì)胞的過(guò)度活化和增殖。這一特性使其成為研究T細(xì)胞免疫調(diào)節(jié)機(jī)制、器官移植排斥反應(yīng)及自身免疫性疾病發(fā)病機(jī)制的重要工具。 在科研應(yīng)用中,該抗體可用于體外細(xì)胞培養(yǎng)模型,研究免疫細(xì)胞的分化、功能及信號(hào)轉(zhuǎn)導(dǎo)通路;也可通過(guò)動(dòng)物模型評(píng)估其對(duì)免疫相關(guān)疾病的干預(yù)效果,為新療法的開(kāi)發(fā)提供實(shí)驗(yàn)依據(jù)。此外,其高度的特異性和生物學(xué)活性,使其在等檢測(cè)手段中作為特異性探針,用于IL-2Rα的定位與定量分析。 該產(chǎn)品僅用于科研實(shí)驗(yàn),不可用于臨床治療或診斷用途。其生產(chǎn)過(guò)程嚴(yán)格遵循重組蛋白表達(dá)的標(biāo)準(zhǔn)流程,確保產(chǎn)品的高純度和批次間穩(wěn)定性,為科研工作者提供可靠的實(shí)驗(yàn)材料支持。通過(guò)對(duì)IL2RA信號(hào)通路的深入研究,有望為免疫相關(guān)疾病的發(fā)病機(jī)制解析及治療靶點(diǎn)發(fā)現(xiàn)提供重要理論基礎(chǔ)。
  • Uniprot No.:
  • 基因名:
  • 別名:
    CD25 research-grade biosimilar; dacliximab research-grade biosimilar; daclizumab follow-on biologic research-grade biosimilar; Jiannipai research-grade biosimilar; Recombinant Humanized Anti-CD25 Monoclonal Antibody research-grade biosimilar; Xenopax research-grade biosimilar ;IL2RA antibody; Interleukin-2 receptor subunit alpha antibody; IL-2 receptor subunit alpha antibody; IL-2-RA antibody; IL-2R subunit alpha antibody; IL2-RA antibody; TAC antigen antibody; p55 antibody; CD antigen CD25 antibody
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human IL2RA protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類(lèi)型:
    Monoclonal
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    0.01M PBS,pH7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用說(shuō)明:
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    3-4 weeks
  • 用途:
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.
  • 基因功能參考文獻(xiàn):
    1. Results are in line with the hypothesis that in the early phase of ALS, neuroprotective helper T cells infiltrate in the affected areas in the lumbar spinal cord. This was reflected in higher peripheral percentage of CD4(+) helper T cells and higher expression of FOXP3 and IL-2Ralpha. PMID: 29574662
    2. a significant association was found between IL2RA SNP and susceptibility to alopecia areata in Iranian cohort PMID: 29979892
    3. The gene polymorphisms at the loci of IL2RA rs2104286 and rs12722489 are closely associated with susceptibility to MS in the Chinese. PMID: 30352019
    4. Higher frequency of IL2RA SNP could not be detected among multiple sclerosis patients. The difference of frequencies was statistically insignificant between groups, probably, due to low power of analysis and inadequate sample size. PMID: 29141792
    5. Our meta-analysis suggests that the rs2104286 A allele is associated with increased MS risk in both Caucasians and Asians, whereas the rs12722489 C allele is associated with elevated MS risk in Caucasians but not in Asians. PMID: 29648897
    6. sIL-2R could be a promising new marker for determining inflammatory disease activity in CRPS. PMID: 28634419
    7. Relationship between soluble CD25 and gene expression in healthy individuals and patients with multiple sclerosis. PMID: 28511943
    8. Increased serum level of soluble interleukin-2 receptor is associated with a worse response of metastatic clear cell renal cell carcinoma to interferon alpha and sequential VEGF-targeting therapy. PMID: 28545581
    9. Data show that interleukin-2 receptor alpha, tumor necrosis factor receptor 1, serum STimulation-2 (IL1RL1 gene product), and regenerating islet-derived 3-alpha were significantly associated with non-relapse mortality. PMID: 28126963
    10. High IL2RA expression is associated with CRLF2-rearranged acute lymphoblastic leukemia. PMID: 28866095
    11. Inhibits CD25 translation through regulation of the LKB1-AMPK-mTOR pathway to suppress T cells. PMID: 28230853
    12. Among patients with a low pretreatment sIL-2R level who exhibited a positive response to R-CHOP, the posttreatment sIL-2R level may help to identify those with a poor prognosis. PMID: 28413914
    13. The findings not only confirm the predictive power of CD25 expression for Philadelphia chromosome translocation (Ph)+ but also demonstrate that CD25 expression is associated with RD (a biomarker correlated with prognosis) in Ph- patients. The latter finding is likely associated with underlying molecular abnormalities, including Ph-like genotype. PMID: 28430957
    14. Through GWAS, we found that emotion dysregulation is associated at genome-wide level significance in a sex-specific manner, with a SNP in IL2RA in men. PMID: 27643478
    15. it has been shown that CD25 serves as a negative growth regulator of Chronic myeloid leukemia leukemic stem cells. PMID: 28457753
    16. Decidual stromal cells affect IL-2 production and IL-2R expression and signaling. PMID: 27651429
    17. The single nucleotide variant rs12722489 determines differential ERalpha binding and enhancer properties of an IL2RA intronic region. PMID: 28234966
    18. CDK6-mediated suppression of CD25 is required for initiation of T-ALL by activated Notch1 PMID: 26707936
    19. CD4(+) CD25(+) GARP(+) Treg cells are defective in dilated cardiomyopathy patients and GARP seems to be a better molecular definition of the regulatory phenotype. PMID: 28207945
    20. Studies indicate many potential uses of soluble interleukin-2 receptor measurement in the diagnosis and treatment of hemophagocytic syndromes. PMID: 28497365
    21. Data suggest that differential methylation of the IL2RA promoter in T cells could be an important pathogenic mechanism in multiple sclerosis. PMID: 28077880
    22. Sustained STAT5 transcription factor (STAT5) phosphorylation is necessary to induce long-term interleukin 2 receptor subunit alpha (CD25) expression in T lymphocytes. PMID: 27936140
    23. Gastric adenocarcinoma patients present with increased PD-1(+) lymphocytes and CD4(+)CD25(+)FOXP3(+) regulatory T cells in the peripheral blood. PMID: 28031121
    24. The serum concentration of soluble IL2 receptor are increased in patients with Kawasaki disease. (Review) PMID: 28081636
    25. CD25 is an independent prognostic factor in elderly AML patients. Alternative therapies for CD25-positive elderly AML patients are needed. PMID: 28097942
    26. The study demonstrated Increased level of CD25 in patients with active vitilligo. PMID: 27556155
    27. CD45RA distinguishes CD4+CD25+CD127-/low TSDR demethylated regulatory T cell subpopulations with differential stability and susceptibility to tacrolimus-mediated immunosuppression. PMID: 28118317
    28. Combination with anti-programmed cell death protein-1 (PD-1) antibodies promoted complete tumor rejection, indicating the relevance of CD25 antigen as a therapeutic target and promising substrate for future combination approaches in immune-oncology. PMID: 28410988
    29. A compensatory mechanism of IL-7-mediated homeostatic proliferation can restore the inhibitory network of CD24+Foxp3+Treg cell after anti-CD25 induction therapy in islet allotransplantation. PMID: 27306531
    30. (99) Tc-methylene diphosphonate may improve the activity of RA through upregulating the frequency of peripheral gammadelta T cells and CD4(+) CD25(+) Foxp3(+) Tregs as well as affecting the serum cytokine environment by increasing TGF-beta and decreasing TNF-alpha and IL-6. PMID: 24467668
    31. IL-2Ra Interleukin-2 receptor antagonists (IL-2Ra) reduces the risk on new-onset diabetes after transplantation (NODAT) in liver transplant recipients. PMID: 26588180
    32. The percentages of CD8(+)CD25(+)FoxP3(brigh) Tregs correlate with mean peak expiratory flow. PMID: 25921629
    33. Efficiently downregulated the percentages of CD4+CD25+Foxp3+ regulator T (Treg) cells. PMID: 27431260
    34. introduce the combined use of CD25 and properly strati fi ed CD135 values as alternatives to testing for the FLT3-ITD mutation PMID: 27087256
    35. this study shows that PTPN22 genetic polymorphisms play role in predisposition of type 1 diabetes mellitus in Egyptian children PMID: 27288719
    36. dissected the first intron of the IL2RA gene and selected several single nucleotide polymorphisms (SNPs) that may influence the regulation of the IL2RA gene in cell types relevant to autoimmune pathology PMID: 27876533
    37. Its levels correlate to disease stage, assess response to therapy and are predictive of recurrence or better survival. We suggest, therefore, using sIL-2R as a reliable prognostic marker in HNC patients as a single marker, or in a combined panel of biomarkers. PMID: 27466555
    38. CD25 had an adverse prognostic impact on these patients, and this poor prognosis may not be overcome, even with transplant. Patients with AML with residual CD25-positive blasts at the time of transplant may require additional therapy before or after transplant to improve survival. PMID: 26422713
    39. IL2RA and TAGAP are novel vitamin D target genes. The vitamin D response is observed in samples from both the multiple sclerosis (MS) patients and controls, and is not dependent on the genotype of MS-associated SNPs in the respective genes. PMID: 26765264
    40. Anti-CD25 recombinant immunotoxin LMB-2 had phase I activity limited by immunogenicity and rapid growth. PMID: 26350263
    41. Enhanced pretreatment CD25 expression on CD4+ T cells was associated with decreased survival rate of acute myeloid leukemia patients. PMID: 26721345
    42. A decrease of CD4(+) CD25(+) CD127(low) FoxP3(+) regulatory T cells with impaired suppressive function had been found in untreated ulcerative colitis patients. PMID: 26333292
    43. Data show that an ultra-high level of serum serum soluble interleukin-2 receptor (sIL-2R) at diagnosis is a significant poor prognostic biomarker for angioimmunoblastic T-cell lymphoma (AITL). PMID: 25563559
    44. The rs2104286 G allele in IL2RA is present at higher frequencies in neuromyelitis optica patients than in healthy controls within a Southern Han Chinese population. PMID: 24257225
    45. Our results suggest that the CD34/CD25/CD123/CD99(+) LAIP is strictly associated with FLT3-ITD-positive cells. PMID: 25957287
    46. Interleukin-2 Receptor alpha-Chain (CD25) Expression Predicts a Poor Prognosis in Acute Myeloid Leukemia PMID: 26375984
    47. Data show that interleukin 2 receptor subunit alpha (IL2RA)-single nucleotide polymorphism rs2104286 and serum sIL2Ralpha-level associated with rheumatoid arthritis (RA)-persistence. PMID: 26350950
    48. CD4+CD45RO+CD25-/lowCD127+: CD4+CD45RO+CD25hiCD127-/low ratio in peripheral blood indicates heart transplant recipients at risk for cardiac allograft vasculopathy. PMID: 25539460
    49. analysis of sIL-2R levels in sarcoidosis patients with renal insufficiency PMID: 25745051
    50. all five single nucleotide polymorphisms in the IL2RA gene are risk factors for type 1 diabetes risk. PMID: 26249556

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  • 相關(guān)疾?。?/div>
    Diabetes mellitus, insulin-dependent, 10 (IDDM10); Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41)
  • 亞細(xì)胞定位:
    Membrane; Single-pass type I membrane protein.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 6008

    OMIM: 147730

    KEGG: hsa:3559

    STRING: 9606.ENSP00000369293

    UniGene: Hs.231367



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