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  4. IL25 (XKH-001 Biosimilar) Recombinant Monoclonal Antibody

IL25 (XKH-001 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA875653MB2HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    IL25 (XKH-001 Biosimilar Antibody)重組單克隆抗體是一種專為科研用途開發(fā)的生物制劑。該產(chǎn)品通過(guò)重組DNA技術(shù)制備，具有高特異性和高親和力，可精準(zhǔn)識(shí)別并結(jié)合IL25（白細(xì)胞介素25）靶點(diǎn)，為相關(guān)研究提供可靠的工具。 IL25作為一種重要的細(xì)胞因子，在免疫調(diào)節(jié)、炎癥反應(yīng)及多種疾病的病理生理過(guò)程中發(fā)揮關(guān)鍵作用。該重組單克隆抗體的研發(fā)旨在支持IL25相關(guān)的基礎(chǔ)研究，包括其信號(hào)通路機(jī)制、生物學(xué)功能及潛在的疾病關(guān)聯(lián)等。通過(guò)特異性阻斷或檢測(cè)IL25，研究人員可深入探索其在免疫應(yīng)答、過(guò)敏性疾病、自身免疫性疾病等領(lǐng)域的作用。 該抗體采用先進(jìn)的重組表達(dá)系統(tǒng)生產(chǎn)，確保了批次間的穩(wěn)定性和高純度，有效降低實(shí)驗(yàn)背景干擾。其嚴(yán)格的質(zhì)量控制流程保證了產(chǎn)品的生物學(xué)活性和結(jié)構(gòu)完整性，適用于ELISA、及體外中和實(shí)驗(yàn)等多種實(shí)驗(yàn)方法。 作為科研用試劑，IL25 (XKH-001 Biosimilar Antibody)重組單克隆抗體為闡明IL25的生理和病理意義提供了有力支持，有助于推動(dòng)免疫學(xué)、分子生物學(xué)及相關(guān)疾病機(jī)制的研究進(jìn)展，為開發(fā)新的治療策略奠定實(shí)驗(yàn)基礎(chǔ)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    XKH001 research-grade biosimilar; XKH 001 research-grade biosimilar; XKH-001 research-grade biosimilar ;IL25 antibody; IL17E antibody; UNQ3120/PRO10272 antibody; Interleukin-25 antibody; IL-25 antibody; Interleukin-17E antibody; IL-17E antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human IL25 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.
  • 基因功能參考文獻(xiàn)：
    1. this review details the structural characteristics, expression patterns, responder cells, biological properties, and role of IL-25 in disease pathogenesis PMID: 30345318
    2. this study shows that IL-25 reduces Th17 cells and inflammatory responses in human peripheral blood mononuclear cells PMID: 29966691
    3. Endometrial stromal cells differentiate into decidual stromal cells in the presence of ovarian hormones, resulting in the upregulation of IL25/IL17RB expression in endometrial stromal cells. PMID: 29257317
    4. In conclusion, the findings of the present study suggest that IL-25 but not IL-33 might contribute to the pathogenesis of chronic eosinophilic inflammation of the lung in patients with CEP. PMID: 28875265
    5. Nasal Il-25 is overexpressed in patients with chronic rhinosinusitis with nasal polyps and airway hypersensitiveness. PMID: 28870448
    6. IL-25-induced activation of nasal fibroblast and its association with the remodeling of chronic rhinosinusitis with nasal polyposis PMID: 28771607
    7. The authors concluded that IL-25 provides protection from amebiasis, which is dependent upon intestinal eosinophils and suppression of TNF-alpha. PMID: 28246365
    8. Inhibition of IL-25 resulted in decreased type 2 T cells and macrophages in the primary tumor microenvironments, both reported to enhance breast tumor invasion and subsequent metastasis to the lung. PMID: 27909985
    9. Our findings suggest that the IL-25/IL-25R axis may play an important role in promoting the recruitment and proinflammatory function of eosinophils in allergic asthma. PMID: 27685606
    10. Chronic rhinosinusitis with nasal polyps (CRSwNP) epithelial cells release TSLP and IL-25 when stimulated by poly(I:C) but not by DP or AF, suggesting that viral infection may contribute to maintain and amplify the T2 immune response seen in CRSwNP. PMID: 28127565
    11. Increased induction and expression of TSLP, IL-25, and IL-33 from nasal epithelial cells contribute to the pathophysiology of eosinophilic chronic rhinosinusitis. PMID: 26540312
    12. Women with endometriosis showed significantly higher levels of IL-25 in their PF (p=0.019) compared to controls. IL-25 levels did not correlate with the stage of endometriosis. PMID: 26852387
    13. IL-8 and IL-25 are targets of miR-20b. PMID: 26845056
    14. Our findings indicate that the alarmin cytokines IL-33 and IL-25 increase basophil activation and migratory potential, and may pose as a novel therapeutic targets for the treatment of allergic asthma. PMID: 26762527
    15. The IL17E rs79877597 SNP was a modifier of the risk for psoriasis disease severity and psoriatic arthritis. PMID: 26347322
    16. Findings indicate that the release of interleukin 25 (IL-25) from tumour-associated fibroblasts (TAFs) may serve as a check point for control of mammary tumour metastasis. PMID: 27089063
    17. IL-25 upregulated PD-L1 surface expression through the signaling pathways of JNK and STAT3, with STAT3 found to constitutively occupy the proximal region of the PD-L1 promoter. PMID: 26321145
    18. we have demonstrated that the expression of ET-1 and IL-25 was coordinately upregulated in the lesional keratinocytes of patients with AD and a murine AD model. PMID: 25903653
    19. IL-25 overexpression was observed in eosinophilic chronic rhinosinusitis and may serve as a mediator of eosinophilic CRS. PMID: 25975248
    20. expression of immunoreactivity for IL-17A, IL-17RA, IL-17E, and IL-17F was significantly elevated in prostatic tissue from benign prostatic hyperplasia and prostate cancer compared with that in controls PMID: 26356122
    21. This article focuses on evidence for the role of IL-25, IL-33 and TSLP in human allergic disease; although this triad of cytokines is described as epithelial derived, it is clear that their expression within lung tissue is much more widespread.[Review] PMID: 25705788
    22. The levels of mRNA for IL-25 were not significantly elevated in parotid gland tissues from Kimura Disease patients as compared to controls. PMID: 25676453
    23. asthmatic epithelial cells have an increased intrinsic capacity for expression of a pro-type 2 cytokine in response to a viral infection, and IL-25 is a key mediator of RV-induced exacerbations of pulmonary inflammation PMID: 25273095
    24. increased levels in patients with chronic rhinosinusitis with nasal polyps PMID: 25704964
    25. Because IL-25 has a major role in triggering type 2 responses, bronchial epithelial IL-25 expression is likely a key determinant of type 2 response activation in asthma PMID: 25133876
    26. Human chorionic gonadotropin up-regulates Il25, promoting the proliferation of decidual stromal cells by activation of JNK and AKT signal pathways. PMID: 24746746
    27. Patients with the 'IL-5, IL-17A, IL-25-high' airway inflammatory pattern are often uncontrolled asthmatics, despite daily treatment. PMID: 23957336
    28. IL-25 and type 2 innate lymphoid cells have roles in development of pulmonary fibrosis PMID: 24344271
    29. IL-25 expression is markedly reduced during human and experimental fulminant hepatitis. PMID: 23564603
    30. IL-25 and IL-33-driven type-2 innate lymphoid cells have roles in atopic dermatitis PMID: 24323357
    31. IL-25 enhances herpes simplex virus (HSV)-1 and vaccinia virus replication by inhibiting filaggrin expression, and IL-25 acts synergistically with IL-4 and IL-13 to enhance HSV-1 replication in vitro PMID: 23657503
    32. Suggest that IL-25 production by airway epithelial cells is regulated by the transcription and protein release levels and that allergen proteases likely play pivotal roles in both biological processes. PMID: 23590308
    33. Our data demonstrate that IL-33 plays a critical role in the rapid induction of airway contraction by stimulating the prompt expansion of IL-13-producing type 2 innate lymphoid cells, whereas IL-25-induced responses are slower and less potent. PMID: 23810766
    34. IL-25 Is Decreased in Sera of Patients With inflammatory bowel disease. PMID: 23429464
    35. IL-25 secreted from epithelial cells has the potential to promote airway remodeling in asthma. PMID: 22691357
    36. We observed significant downregulation of IL-25 in women with recurrent miscarriage compared with controls. PMID: 22266274
    37. IL-25 production is differently regulated by TNF-alpha and TGF-beta1 in the human g PMID: 20944558
    38. production is linked to the amount of specific IgE antibodies in blood samples of 6 yr old children in Germany PMID: 20492545
    39. Findings suggest that IL-25 is elevated in asthma and contributes to angiogenesis. PMID: 21205894
    40. IL-25 may have a role in atopic dermatitis PMID: 20861853
    41. Eosinophils are the main source of IL-25, whereas activated CD4+ memory T cells are the IL-17RB-expressing cells in Churg-Strauss syndrome. PMID: 20729468
    42. IL-17A and IL-25 had opposing effects on thymic stromal lymphopoietin regulation in human nasal epithelial cells PMID: 19968632
    43. Overexpression of IL-17E up-regulates gene expression of Th2 cytokines and induces growth retardation, jaundice, and multiorgan inflammation in a transgenic mouse model. PMID: 11714825
    44. Transgenic overexpression from humans into mice results in eosinophilia, B-lymphocyte hyperplasia, and altered antibody production. PMID: 12239140
    45. IL-17E may contribute to the induction and maintenance of eosinophilic inflammation by acting on lung fibroblasts. This supports a role for IL-17E in asthma pathophysiology. PMID: 16522458
    46. IL-25 acts by amplifying TH2 cell-mediated allergic airway inflammation. IL-25 itself does not significantly induce allergic inflammation in vivo. PMID: 16950278
    47. IL-25 produced by innate effector eosinophils and basophils may augment the allergic inflammation by enhancing the maintenance and functions of TSLP-DC activated adaptive Th2 memory cells PMID: 17635955
    48. The upregulation of costimulation-induced IL-25 receptors and release of cytokines and chemokines from IL-25 treated costimulated Th cells were differentially regulated by intracellular JNK, p38 MAPK and NF-kappaB activity. PMID: 17719653
    49. Blocking IL-25 in an experimental model of allergic asthma prevents airway hyperresponsiveness, a critical feature of clinical asthma. PMID: 17889290
    50. Higher expressions of IL-17E, IL-17A, IL-17BR and IL-17R are associated with oral inflammation. PMID: 19095584

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  • 亞細(xì)胞定位：
    Secreted.
  • 蛋白家族：
    IL-17 family
  • 組織特異性：
    Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 13765

    OMIM: 605658

    KEGG: hsa:64806

    STRING: 9606.ENSP00000328111

    UniGene: Hs.302036



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