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  4. IL1RL2 (Spesolimab Biosimilar) Recombinant Monoclonal Antibody

IL1RL2 (Spesolimab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA888016MB2HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    IL1RL2(Spesolimab Biosimilar Antibody)重組單克隆抗體是一種針對白細胞介素1受體樣2（IL1RL2）的科研用生物試劑。該抗體通過重組DNA技術(shù)在工程細胞中表達，具有高特異性和親和力，可特異性識別并結(jié)合IL1RL2蛋白。 IL1RL2作為IL-1細胞因子家族的受體成員，在免疫調(diào)節(jié)、炎癥反應(yīng)及多種生理病理過程中發(fā)揮重要作用。本產(chǎn)品為科研人員提供了可靠的工具，可用于IL1RL2相關(guān)的基礎(chǔ)研究，包括受體-配體相互作用機制、信號轉(zhuǎn)導(dǎo)通路解析、細胞功能調(diào)控等方向的實驗。 該抗體經(jīng)過嚴格的質(zhì)量控制，確保具有高純度、高活性和批次間一致性。其在某些實驗中表現(xiàn)穩(wěn)定，適用于多種樣本類型的檢測與分析。 作為科研級試劑，本產(chǎn)品僅用于實驗室研究，不用于臨床診斷或治療用途。通過特異性靶向IL1RL2，為探索該受體在免疫疾病、炎癥反應(yīng)及腫瘤發(fā)生等領(lǐng)域的作用機制提供關(guān)鍵支持，助力相關(guān)疾病的病理機制研究及潛在治療靶點的發(fā)現(xiàn)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    BI 655130 research-grade biosimilar; BI-655130 research-grade biosimilar; Immunoglobulin G1, anti-(human interleukin 36 receptor) (humanized monoclonal BI 655130 gamma1-chain), disulfide with humanized monoclonal BI 655130 kappa-chain, dimer research-grade biosimilar; Spesolimab research-grade biosimilar; Spesolimab (genetical recombination) (JAN) research-grade biosimilar; Spesolimab (INN) research-grade biosimilar; spesolimab-sbzo research-grade biosimilar; Spevigo research-grade biosimilar ;IL1RL2 antibody; IL1RRP2 antibody; Interleukin-1 receptor-like 2 antibody; EC 3.2.2.6 antibody; IL-36 receptor antibody; IL-36R antibody; Interleukin-1 receptor-related protein 2 antibody; IL-1Rrp2 antibody; IL1R-rp2 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human IL1RL2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
  • 基因功能參考文獻：
    1. Endothelial cells, including dermal microvascular cells, express a functionally active IL-36 receptor. PMID: 27673278
    2. All human blood lymphocytes express IL-36R. PMID: 27269181
    3. The data identify a novel role for IL-36 signaling in colonic inflammation and indicate that the IL-36R pathway may represent a novel target for therapeutic intervention. PMID: 26813344
    4. single nucleotide polymorphism A471T in the Toll-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 that is present in approximately 2% of the human population, down-regulated IL-36R signaling by a decrease of interaction with IL-1RAcP. PMID: 27307043
    5. The IL36 receptor (IL1RL2) is an important mediator molecule in the inflammatory response. PMID: 27853811
    6. The ubiquitin-binding Tollip protein contributed to IL-36R signaling and increased the accumulation of both subunits of the IL-36R. PMID: 26269592
    7. IL36A-IL36R axis is modulated in patients with primary Sjogren's syndrome. PMID: 25902739
    8. Expression of IL-1Rrp2 by sone dendritic cell subsets may have an important function in the human immune response in vivo via its role in differentiation of inflammatory Th1 lymphocytes. PMID: 22144259
    9. These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra.[IL-38, IL-36R] PMID: 22315422
    10. IL-1alpha and IL-1beta gene polymorphisms do not act as a strong susceptibility factor for MTLE-HS in individuals of Turkish ancestry PMID: 16546408

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Interleukin-1 receptor family
  • 組織特異性：
    Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5999

    OMIM: 604512

    KEGG: hsa:8808

    STRING: 9606.ENSP00000264257

    UniGene: Hs.659863



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