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  4. IL1RL2 (Recibokibart Biosimilar) Recombinant Monoclonal Antibody

IL1RL2 (Recibokibart Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA888016MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    IL1RL2(Recibokibart Biosimilar Antibody)重組單克隆抗體是一種用于科研領(lǐng)域的生物活性分子，其設(shè)計基于對白細(xì)胞介素1受體樣2（IL1RL2）的特異性靶向。該抗體通過重組DNA技術(shù)在工程細(xì)胞中表達(dá)，具有高純度、高親和力的特點(diǎn)，可特異性識別并結(jié)合IL1RL2蛋白，為相關(guān)研究提供可靠的工具。 在免疫調(diào)控研究中，IL1RL2作為細(xì)胞表面受體參與炎癥信號通路的調(diào)節(jié)，其異常表達(dá)與多種免疫相關(guān)疾病的發(fā)生發(fā)展密切相關(guān)。該抗體可用于體外細(xì)胞實(shí)驗(yàn)，通過阻斷或激活I(lǐng)L1RL2介導(dǎo)的信號通路，探究其在免疫應(yīng)答、炎癥反應(yīng)及疾病模型中的功能機(jī)制。同時，在蛋白質(zhì)相互作用研究中，該抗體可通過等技術(shù)，輔助分析IL1RL2與配體或下游信號分子的結(jié)合特性及調(diào)控網(wǎng)絡(luò)。 該產(chǎn)品適用于免疫學(xué)、細(xì)胞生物學(xué)、分子生物學(xué)等領(lǐng)域的基礎(chǔ)研究，為揭示IL1RL2的生理病理作用提供實(shí)驗(yàn)支持。其生產(chǎn)過程嚴(yán)格遵循科研級標(biāo)準(zhǔn)，經(jīng)過多步純化及質(zhì)量控制，確保批次間的穩(wěn)定性和實(shí)驗(yàn)結(jié)果的可重復(fù)性。研究者可根據(jù)具體實(shí)驗(yàn)需求，將其應(yīng)用于細(xì)胞培養(yǎng)、組織切片染色等多種實(shí)驗(yàn)場景，助力深入探索IL1RL2相關(guān)的分子機(jī)制與疾病關(guān)聯(lián)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    HB0034 research-grade biosimilar; HB 0034 research-grade biosimilar; Recombinant humanized anti-interleukin 36R monoclonal antibody(Huaota Biopharma) research-grade biosimilar ;IL1RL2 antibody; IL1RRP2 antibody; Interleukin-1 receptor-like 2 antibody; EC 3.2.2.6 antibody; IL-36 receptor antibody; IL-36R antibody; Interleukin-1 receptor-related protein 2 antibody; IL-1Rrp2 antibody; IL1R-rp2 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human IL1RL2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Receptor for interleukin-36 (IL36A, IL36B and IL36G). After binding to interleukin-36 associates with the coreceptor IL1RAP to form the interleukin-36 receptor complex which mediates interleukin-36-dependent activation of NF-kappa-B, MAPK and other pathways. The IL-36 signaling system is thought to be present in epithelial barriers and to take part in local inflammatory response; it is similar to the IL-1 system. Seems to be involved in skin inflammatory response by induction of the IL-23/IL-17/IL-22 pathway.
  • 基因功能參考文獻(xiàn)：
    1. Endothelial cells, including dermal microvascular cells, express a functionally active IL-36 receptor. PMID: 27673278
    2. All human blood lymphocytes express IL-36R. PMID: 27269181
    3. The data identify a novel role for IL-36 signaling in colonic inflammation and indicate that the IL-36R pathway may represent a novel target for therapeutic intervention. PMID: 26813344
    4. single nucleotide polymorphism A471T in the Toll-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 that is present in approximately 2% of the human population, down-regulated IL-36R signaling by a decrease of interaction with IL-1RAcP. PMID: 27307043
    5. The IL36 receptor (IL1RL2) is an important mediator molecule in the inflammatory response. PMID: 27853811
    6. The ubiquitin-binding Tollip protein contributed to IL-36R signaling and increased the accumulation of both subunits of the IL-36R. PMID: 26269592
    7. IL36A-IL36R axis is modulated in patients with primary Sjogren's syndrome. PMID: 25902739
    8. Expression of IL-1Rrp2 by sone dendritic cell subsets may have an important function in the human immune response in vivo via its role in differentiation of inflammatory Th1 lymphocytes. PMID: 22144259
    9. These data provide evidence that IL-38 binds to the IL-36R, as does IL-36Ra.[IL-38, IL-36R] PMID: 22315422
    10. IL-1alpha and IL-1beta gene polymorphisms do not act as a strong susceptibility factor for MTLE-HS in individuals of Turkish ancestry PMID: 16546408

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Interleukin-1 receptor family
  • 組織特異性：
    Expressed in synovial fibroblasts and articular chondrocytes. Expressed in keratinocytes and monocyte-derived dendritic cells. Expressed in monocytes and myeloid dendritic cells; at protein level.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5999

    OMIM: 604512

    KEGG: hsa:8808

    STRING: 9606.ENSP00000264257

    UniGene: Hs.659863



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