日本高潮视频在线观看-亚洲中文字幕永不卡-精品亚洲一区二区三区-伦理片夜夜躁狠狠躁日日躁-日本最新免费不卡二区-国产精品口爆一区二区三区-av一区二区三区高清-大鸡巴疯狂抽插小穴视频-日韩中文国产在线观看免费视频

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 科研級(jí)生物類(lèi)似抗體
  4. IL18 (GSK1070806 Biosimilar) Recombinant Monoclonal Antibody

IL18 (GSK1070806 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA614514MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    IL18 (GSK1070806 Biosimilar Antibody) 重組單克隆抗體是一種針對(duì)人白細(xì)胞介素18（IL-18），其別名包括Iboctadekin抗體、IFNγ誘導(dǎo)因子抗體、IL-18抗體等多種名稱(chēng)。該抗體以重組人IL18蛋白制備，具有高度的種屬反應(yīng)性，專(zhuān)門(mén)識(shí)別人源IL18分子。 在藥物研發(fā)領(lǐng)域，GSK1070806 是一款靶向 IL-18 結(jié)合蛋白（IL-18BP）的單克隆抗體，并非 IL-18 抗體類(lèi)似物。其作用機(jī)制是通過(guò)特異性結(jié)合 IL-18BP，解除后者對(duì) IL-18 的天然抑制作用，進(jìn)而增強(qiáng) IL-18 介導(dǎo)的免疫應(yīng)答，目前主要探索其在黑色素瘤、非小細(xì)胞肺癌等惡性腫瘤免疫治療中的潛力，相關(guān)研究處于 Ⅰ/Ⅱ 期臨床試驗(yàn)階段。目前，其相關(guān)臨床研究主要探索在類(lèi)風(fēng)濕關(guān)節(jié)炎、銀屑病、炎癥性腸病等自身免疫性疾病中的治療潛力，同時(shí)也在腫瘤免疫治療中作為聯(lián)合療法的候選藥物進(jìn)行評(píng)估，旨在通過(guò)調(diào)節(jié)腫瘤微環(huán)境中的炎癥狀態(tài)增強(qiáng)抗腫瘤免疫應(yīng)答。 該抗體是研究IL18生物學(xué)功能的重要工具。它可用于多種實(shí)驗(yàn)，助力科學(xué)家在細(xì)胞和組織水平檢測(cè)IL18的表達(dá)與定位，深入探究其在免疫調(diào)節(jié)、炎癥反應(yīng)及疾病模型中的作用機(jī)制。此外，通過(guò)中和IL18活性，該抗體還可用于構(gòu)建IL18功能缺陷的實(shí)驗(yàn)?zāi)Ｐ?，為解析IL18相關(guān)信號(hào)通路及篩選潛在治療靶點(diǎn)提供支持，進(jìn)一步推動(dòng)IL18相關(guān)疾病的基礎(chǔ)研究與轉(zhuǎn)化醫(yī)學(xué)發(fā)展。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Iboctadekin antibody; IFN gamma inducing factor antibody; IFN-gamma-inducing factor antibody; IGIF antibody; IL 1 gamma antibody; IL 18 antibody; IL 1g antibody; IL-1 gamma antibody; IL-18 antibody; IL1 gamma antibody; IL18 antibody; IL18 protein antibody; IL18_HUMAN antibody; IL1F4 antibody; IL1g antibody; IL1gamma antibody; ILIF4 antibody; Interferon gamma inducing factor antibody; Interferon gamma-inducing factor antibody; Interleukin 1 gamma antibody; Interleukin 18；interferon-gamma-inducing factor antibody; Interleukin 18 antibody; Interleukin-1 gamma antibody; Interleukin-18 antibody; Interleukin18 antibody; MGC12320 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human IL18 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類(lèi)型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    A proinflammatory cytokine primarily involved in polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (Probable). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (Probable).
  • 基因功能參考文獻(xiàn)：
    1. The results of the linkage disequilibrium test showed that the -137G/C and -607G/T sites had no linkage disequilibrium in the present study. PMID: 29926984
    2. SNPs associated with genetically determined high activity of TLR5 among patients with CD and genetically determined high IL-12 and IL-18 levels among patients with UC. PMID: 28139755
    3. The adipose tissue IL-18R/IL-18 expression is enhanced in obesity which associates with proinflammatory gene signature and insulin resistance in these individuals. PMID: 28508444
    4. Our study implied that elevated IL-18 expression and downregulation of GAS5 in serums might contribute to insulin resistance in polycystic ovary syndrome patients. PMID: 29648472
    5. Studied serum level of interleukin 18 (IL18) in HIV and Hepatitis C (HCV) coinfection and monoinfection. Found shown that IL-18 is increased in HIV/HCV coinfection when compared with monoinfection and that this increase is likely due to additive sensing of both viruses. PMID: 27927859
    6. not associated with obesity in this study PMID: 28634744
    7. multiple myeloma patients with IL-18 (rs16944) TT had the highest hemoglobin concentration PMID: 30211233
    8. These results suggest that increased IL-18 secretion from larger numbers of neutrophils elicits mechanical hyperalgesia. PMID: 29353540
    9. The results of this study suggests that IL-18 rs187238 and rs1946518 SNPs may be the cause of the AA susceptibility. PMID: 29349811
    10. Studied association of single nucleotide polymorphisms of interleukin-18 (IL 18) and lower extremity deep venous thrombosis in a Chinese population. PMID: 29105174
    11. PI3K is a signal linker between L-selectin and PSGL-1 in IL-18 transcriptional activation at the promoter level. PMID: 29218606
    12. IL-18 is a susceptibility gene for the disease in southern Chinese children. PMID: 30059753
    13. Postoperative serum Cystatin C, IL-18 and Uric acid after 24h were significantly associated with acute kidney injury PMID: 29627485
    14. IL-18 is elevated in polycystic ovary syndrome patients, even in lean ones, and is correlated with insulin resistance and atherosclerotic cardiovascular risk PMID: 29105530
    15. HuR plays an important role in the progression of esophageal carcinoma by targeting IL-18. PMID: 28231690
    16. The IL18 promoter SNP, rs1946518, is a potential risk factor of periodontitis among young Japanese women. PMID: 29129846
    17. The results of this study suggest that IL18 rs187238 and rs1946518 polymorphisms may be associated with an increased risk of gestational diabetes mellitus as well as with BMI in pregnant women. PMID: 28580570
    18. This is the first study to demonstrate that higher pre-treatment IL-18 is associated with HBeAg seroconversion in patients with HIV/HBV co-infection after 48 weeks of HBV cART, which suggests a role for the inflammasome in a favorable response to treatment. PMID: 28195558
    19. Polymorphisms in the IL-18 gene are associated with viral load in Hepatitis B virus . PMID: 30045250
    20. higher level of IL-18 was observed in the monocyte supernatant of the extremely preterm group during late-onset sepsis PMID: 29042061
    21. Increased production of IL-18 in the gut-associated lymphoid tissue and peripheral blood of HIV infected patients. PMID: 29672590
    22. this review discusses IL-18 biological properties and role in disease pathogenesis PMID: 29247988
    23. IL-18 mRNA expression was increased significantly in chronic myeloid leukemia patients PMID: 29097263
    24. these results suggest that the HIV-induced IL-18 plays a role in increased intestinal permeability and microbial translocation observed in HIV-infected individuals. PMID: 29601578
    25. IL-18 gene variants may serve as important biomarkers in predicting the occurrence of nasopharyngeal carcinoma in Asian population. PMID: 29185028
    26. The association of polymorphisms -137 (rs187238) and -607 (rs1946518) in the interleukin-18 (IL-18) promoter with risk of hepatocellular carcinoma (HCC). PMID: 28000712
    27. These findings indicate that the IL-18 rs1946518 SNP in the donor liver is a risk factor for developing bacterial infection after liver transplantation. PMID: 29061223
    28. Serum levels of IL-18 in nephropathic patient significantly rise and Serum levels of IL-18 might be a predictor factor of progression of diabetic nephropathy. PMID: 27663212
    29. A higher IL-18 immunostaining in stroma of IBC and LABC was observed in comparison with tumor cells, but stromal immunoexpression was similar between IBC and LABC. PMID: 28766916
    30. IL-18 was increased in lung myeloid cells in severe chronic obstructive pulmonary disease. PMID: 28830544
    31. a large proportion blood basophils from patients with asthma express IL-18 and IL-18BP. mast cells and basophils are implicated in the pathogenesis of asthma via an IL-18-related mechanism. PMID: 29505668
    32. On PICU day 1, interleukin-18 predicted acute kidney injury with area under the curve=0.82, but neutrophil gelatinase-associated lipocalin and liver fatty acid binding protein predicted acute kidney injury with area under the curve of less than or equal to 0.69; on PICU day 2, area under the curve was higher. Interleukin-18 and liver fatty acid binding protein on day 1 predicted prolonged acute kidney injury. PMID: 28430754
    33. Data show that tumor-derived IL-18 induced PD-1 expression on NK cells and is associated with poor prognosis in triple-negative breast cancer. PMID: 28415798
    34. IL-23, alone and in combination with IL-18 and sRAGE, identified bacterial meningitis with excellent accuracy. Following validation, these markers could aid clinicians in diagnosis of bacterial meningitis and decision-making regarding prolongation of antibiotic therapy PMID: 29394248
    35. cardiac IL-18 and circulating IL-18 are involved in the pathogenesis of Fabry cardiomyopathy and left ventricular hypertrophy. PMID: 27888626
    36. Erdr1 is negatively expressed relative to Il-18 in psoriatic lesional skin. PMID: 26990875
    37. rs187238 was not associated with T1D in the Euro-Brazilian population. PMID: 28973736
    38. IL-18 (mRNA) in skeletal muscle appears to be involved in the regulation of intramuscular lipid metabolism and hypertriglyceridemia PMID: 29342149
    39. The evidence for influenza A virus activation via an indirect, IL-18-dependent mechanism indicates that MAIT cells are protective in influenza, and also possibly in any human disease process in which inflammation and IL-18 production occur. PMID: 27543331
    40. The development of urticaria, asthma, dermatitis, rhinitis, and eosinophilic disorders all have demonstrated correlations to increased IL-18 levels either in the tissue or systemically. IL-18 represents a novel site of immune regulation in not only allergic conditions, but also autoimmune diseases and other instances of aberrant immune functioning. PMID: 27496752
    41. Results suggest that a common functional IL18 haplotype associated with heightened proinflammatory responses confers susceptibility to stress-related depression and anxiety through effects on threat-related amygdala function, a risk pathway specific to women. PMID: 27430614
    42. human platelets contain transcripts for the IL-18 gene. They synthesize the cytokine de novo, process and release it upon activation. PMID: 27914933
    43. abnormal IL-18 expression is induced by genital infection and induces damage to male reproductive capacity, thereby causing male infertility PMID: 26856767
    44. IL-18 level was found to be significantly elevated in CAD patients compared with control individuals PMID: 28059484
    45. The serum levels of IL-37, which were correlated with antibody production and the serum levels of total IL-18 and IL-18BP, were elevated in the patients with primary Sjogren's syndrome. PMID: 28057714
    46. an imbalance in the production of IL-18 and its antagonist (an increase in the production of IL-18 with a decrease, no increase or an insufficient increase in the production of IL-18BP) has been described in many chronic inflammatory diseases in humans. PMID: 26898120
    47. among systemic sclerosis patients in China, dyspnea was significantly associated with IL-18 -607C/A genotype frequency PMID: 27098064
    48. We conclude that IL-18 protein and messenger RNA levels are increased in the endometrium of patients with PCOS, and this effect is correlated with body mass index. PMID: 27313119
    49. Serum IL-18 levels are significantly elevated in depressive patients. PMID: 27455146
    50. IL-18 cooperates with IL-15 to promote group 3 innate lymphoid cell (ILC3) proliferation and IL-22 production; describe an IL-18-induced, NF-kappaB-mediated mechanism that regulates IL-22 in ILC3s; at steady-state, IL-18 produced by dendritic cells mediates IL-22 production by ILC3s to help maintain normal tissue integrity PMID: 28842466

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Secreted.
  • 蛋白家族：
    IL-1 family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 5986

    OMIM: 600953

    KEGG: hsa:3606

    STRING: 9606.ENSP00000280357

    UniGene: Hs.83077



×
生命科學(xué)計(jì)算平臺(tái)