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  4. IL13RA1 (eblasakimab Biosimilar) Recombinant Monoclonal Antibody

IL13RA1 (eblasakimab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA011591MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    IL13RA1（eblasakimab Biosimilar Antibody）重組單克隆抗體是一種針對白細(xì)胞介素13受體α1亞基（IL13RA1）的生物治療藥物，其別名為bB128O4.2.1、CD213a1抗體、CT19抗體等。該抗體以重組人IL13RA1蛋白制備而成，具有高度的種屬反應(yīng)性，主要針對人類IL13RA1靶點(diǎn)。 IL13RA1作為IL-13信號通路的關(guān)鍵受體亞基，與特發(fā)性肺纖維化、哮喘等多種炎癥性疾病及腫瘤的發(fā)生發(fā)展密切相關(guān)。eblasakimab通過特異性結(jié)合IL13RA1，阻斷IL-13介導(dǎo)的下游信號傳導(dǎo)，從而抑制炎癥反應(yīng)和纖維化進(jìn)程。目前，相關(guān)臨床研究主要探索eblasakimab在特發(fā)性肺纖維化、重度哮喘等疾病中的治療潛力，評估其安全性、有效性及劑量優(yōu)化方案。 該抗體可作為特異性檢測工具，用于實(shí)驗，幫助研究人員分析IL13RA1在正常組織與病變組織中的表達(dá)差異，揭示其在疾病模型中的作用機(jī)制。此外，通過阻斷IL13RA1信號，該抗體還可用于體外細(xì)胞實(shí)驗或動物模型研究，探索IL-13/IL13RA1通路在免疫調(diào)節(jié)、纖維化及腫瘤微環(huán)境調(diào)控中的分子機(jī)制，為開發(fā)新型靶向治療策略提供實(shí)驗基礎(chǔ)。其高度的特異性和人源反應(yīng)性，使其成為IL13RA1相關(guān)基礎(chǔ)研究和轉(zhuǎn)化醫(yī)學(xué)研究的重要工具。
  • Uniprot No.：
  • 基因名：
  • 別名：
    bB128O4.2.1；interleukin 13 receptor; alpha 1 antibody; Cancer/testis antigen 19 antibody; CD213a1 antibody; CD213A1 Antigen antibody; CT 19 antibody; CT19 antibody; I13R1_HUMAN antibody; IL 13 receptor subunit alpha 1 antibody; IL 13R alpha 1 antibody; IL 13R subunit alpha 1 antibody; IL 13Ra antibody; IL 13RA1 antibody; IL-13 receptor subunit alpha-1 antibody; IL-13R subunit alpha-1 antibody; IL-13R-alpha-1 antibody; IL-13RA1 antibody; IL13 receptor alpha 1 chain antibody; IL13R antibody; IL13RA antibody; Il13ra1 antibody; Interleukin 13 receptor alpha 1 antibody; Interleukin 13 receptor alpha 1 chain antibody; interleukin 13 receptor subunit alpha 1 antibody; Interleukin-13 receptor subunit alpha-1 antibody; NR 4 antibody; NR4 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human IL13RA1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
  • 基因功能參考文獻(xiàn)：
    1. High IL13RA1 expression is associated with Invasive breast Cancer. PMID: 28634667
    2. in humans and mice indicate, for the first time, a role of interleukin-13 receptor alpha1 in myocardial homeostasis and heart failure and suggests a new therapeutic target to treat heart disease. PMID: 28528324
    3. sIL13ralpha1 as a circulating human protein with an unexpected role in glucose metabolism. PMID: 28874358
    4. IL-13Ralpha1 has a protective role in bleomycin-induced pulmonary injury and repair. PMID: 26153764
    5. required for induction of the alternative macrophage activation pathway by IL-13 but not by IL-4 PMID: 25766112
    6. Results identified FAM120A in the IL13/IL13Ralpha2 signaling pathway as a key mediator of invasion and liver metastasis in colon cancer. PMID: 25896327
    7. miR-143 regulation of IL-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients probably partly depends on inhibition of IL13Ralpha1. PMID: 25529447
    8. MiR-143 may be associated with allergic reaction in human mast cells via downregulation of IL13RA1. PMID: 23965966
    9. In humans, IL-13Ralpha1 lies within the PARK12 locus of susceptibility to Parkinson's disease and may have a role in the pathogenesis of this neurodegenerative disease. PMID: 23169588
    10. These results indicate that an inherited polymorphism of the IL-4R controls the ability of the human immune system to regulate the magnitude of IL-17 production PMID: 21294892
    11. The IL-13R A(1) +1398 A/G polymorphism does not contribute to asthma or allergic rhinitis susceptibility. PMID: 21425907
    12. IL-13Ralpha1 is expressed on human CD4(+) T(H)17 cells PMID: 21236478
    13. Mutation and functional analysis in human malignant glioma cells PMID: 11939409
    14. IL4RA and STAT6 are candidate genes for atopic disorders. 26 single-nucleotide polymorphisms (SNPs)and simple repeats are being reported spanning a total of 147kb in IL4RA and STAT6 genes of the Indian population PMID: 12522691
    15. Allele frequency of IL13RA1 polymorphism was not associated with rapid decline of lung function in smokers. PMID: 12594065
    16. Overexpression of IL-13Ralpha1 may play some role in pathogenesis of chronic stage of atopic dermatitis or psoriasis. PMID: 14527737
    17. Bronchial submucosal mast cell IL-13 receptor alpha 1 expression is higher in asthmatics than normal controls. PMID: 16918506
    18. IL-13Ralpha1 polymorphism was associated with higher total IgE in children with atopic asthma PMID: 17006604
    19. the IL13RA1 subunit gene -281T>G and 1365A>G polymorphisms do not contribute to asthma susceptibility or severity, although the IL13RA1 subunit gene locus might be involved in the control of immunoglobulin E production PMID: 17392323
    20. concomitant expression of IL-13Ralpha1 and IL-13Ralpha2 may be associated with the pathogenesis of idiopathic interstitial pneumonia. PMID: 19654941

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Type I cytokine receptor family, Type 5 subfamily
  • 組織特異性：
    Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5974

    OMIM: 300119

    KEGG: hsa:3597

    STRING: 9606.ENSP00000360730

    UniGene: Hs.496646



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