IL12&IL23（Ustekinumab Biosimilar Antibody）重組單克隆抗體是一種針對(duì)白細(xì)胞介素12（IL-12）和白細(xì)胞介素23（IL-23），其來(lái)源于重組人IL12&IL23蛋白，種屬反應(yīng)性為人類。該抗體可特異性結(jié)合IL-12和IL-23共有的p40亞基，以及IL-12特有的p35亞基，因此也被稱為CLMF抗體、IL-12A抗體、IL-12B抗體等，其眾多別名反映了其與細(xì)胞毒性淋巴細(xì)胞成熟因子（CLMF）、自然殺傷細(xì)胞刺激因子（NKSF）等相關(guān)分子的關(guān)聯(lián)性。 Ustekinumab Biosimilar Antibody作為針對(duì)IL-12和IL-23的抗體，Ustekinumab類似物，已在臨床中用于治療銀屑病、克羅恩病等慢性炎癥性疾病。IL-12和IL-23是參與免疫調(diào)節(jié)的關(guān)鍵細(xì)胞因子，在多種自身免疫性疾病的發(fā)病機(jī)制中起重要作用，烏司奴單抗通過(guò)阻斷IL-12/IL-23信號(hào)通路，可抑制炎癥反應(yīng)和免疫細(xì)胞活化。其臨床療效和安全性已通過(guò)相關(guān)研究驗(yàn)證，為患者提供了有效的治療選擇。 該抗體因其對(duì)人IL12&IL23蛋白的高特異性，廣泛應(yīng)用于免疫學(xué)和炎癥相關(guān)機(jī)制的研究。研究人員可利用其檢測(cè)細(xì)胞培養(yǎng)上清液或組織樣本中IL-12和IL-23的表達(dá)水平，探索它們?cè)诿庖邞?yīng)答、疾病發(fā)生發(fā)展中的作用。此外，通過(guò)阻斷實(shí)驗(yàn)，可深入分析IL-12/IL-23通路對(duì)T細(xì)胞分化、細(xì)胞因子分泌等生物學(xué)過(guò)程的調(diào)控，為開發(fā)新的治療靶點(diǎn)提供實(shí)驗(yàn)依據(jù)。其明確的種屬反應(yīng)性（Human）確保了在人類細(xì)胞和組織模型中的適用性，是免疫相關(guān)基礎(chǔ)研究和藥物研發(fā)的重要工具。

P29459&P29460

IL12&IL23

CLMF antibody; CLMF p35 antibody; CLMF p40 antibody; CLMF1 antibody; CLMF2 antibody; Cytotoxic lymphocyte maturation factor 1, p35 antibody; Cytotoxic lymphocyte maturation factor 2 antibody; Cytotoxic lymphocyte maturation factor 35 kDa subunit antibody; Cytotoxic lymphocyte maturation factor 40 kDa subunit antibody; IL 12A antibody; IL 2 subunit p40 antibody; IL-12 subunit p35 antibody; IL-12A antibody; IL-12B antibody; IL12 antibody; IL12, p35 subunit antibody; IL12, subunit p40 antibody; IL12A antibody; IL12A_HUMAN antibody; IL12B antibody; IL35 subunit antibody; Interleukin 12 alpha chain antibody; Interleukin 12 beta chain antibody; Interleukin 12 subunit beta antibody; Interleukin 12, p40 antibody; Interleukin 12A；natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35 antibody; Interleukin 12B；natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40 antibody; Interleukin 12B antibody; Interleukin-12 subunit alpha antibody; Natural killer cell stimulatory factor 1, 35 kD subunit antibody; natural killer cell stimulatory factor 2 antibody; Natural killer cell stimulatory factor, 40 kD subunit antibody; NF cell stimulatory factor chain 1 antibody; NFSK antibody; NK cell stimulatory factor chain 1 antibody; NK cell stimulatory factor chain 2 antibody; NKSF antibody; NKSF1 antibody; NKSF2 antibody; P35 antibody;CLMF antibody; CLMF p40 antibody; CLMF2 antibody; Cytotoxic lymphocyte maturation factor 40 kDa subunit antibody; IL 12B antibody; IL-12 subunit p40 antibody; IL-12B antibody; IL12 p40 antibody; IL12B antibody; IL12B_HUMAN antibody; IMD28 antibody; IMD29 antibody; Interleukin 12 beta chain antibody; Interleukin 12 p40 antibody; Interleukin-12 subunit beta antibody; NK cell stimulatory factor chain 2 antibody; NKSF antibody; NKSF2 antibody

Human

Recombinant Human IL12&IL23 protein

Homo sapiens (Human)

Non-conjugated

Monoclonal

It differs from different batches. Please contact us to confirm it.

0.01M PBS，pH7.4

Liquid

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

In stock

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.