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  4. IL11RA (LASN-01 Biosimilar) Recombinant Monoclonal Antibody

IL11RA (LASN-01 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA623927MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    IL11RA(LASN-01 Biosimilar Antibody)重組單克隆抗體是一種針對白細胞介素11受體α亞基（IL11RA）的重組單克隆抗體，專門設(shè)計用于科研領(lǐng)域的相關(guān)研究。該抗體通過基因工程技術(shù)在體外重組表達，具有高特異性和高親和力，能夠精準識別并結(jié)合IL11RA靶點，為研究IL11RA在生理和病理過程中的功能提供有力工具。 IL11RA作為IL-11受體的重要組成部分，在炎癥反應、組織修復、腫瘤微環(huán)境調(diào)控等多種生物學過程中發(fā)揮關(guān)鍵作用。本產(chǎn)品可廣泛應用于細胞生物學、分子生物學及免疫學等研究領(lǐng)域，例如通過某些實驗技術(shù)，探究IL11RA在不同組織或細胞中的表達水平、亞細胞定位以及與其他信號分子的相互作用。此外，該抗體也可用于體外細胞模型或動物模型中，研究IL11RA信號通路對細胞增殖、分化、凋亡等生物學行為的影響，為深入闡明相關(guān)疾病的分子機制提供實驗基礎(chǔ)。 該重組單克隆抗體經(jīng)過嚴格的質(zhì)量控制，確保產(chǎn)品具有高純度、低內(nèi)毒素含量和良好的批次穩(wěn)定性，能夠滿足科研實驗對試劑可靠性和重復性的要求。使用時，可根據(jù)具體實驗需求選擇合適的稀釋比例和實驗方法，進一步拓展其在IL11RA相關(guān)機制研究、藥物靶點驗證等方面的應用潛力，助力科研人員在炎癥性疾病、纖維化疾病及腫瘤等領(lǐng)域取得突破性進展。
  • Uniprot No.：
  • 基因名：
  • 別名：
    LASN01 research-grade biosimilar; LASN 01 research-grade biosimilar; LASN-01 research-grade biosimilar ;IL11RA antibody; Interleukin-11 receptor subunit alpha antibody; IL-11 receptor subunit alpha antibody; IL-11R subunit alpha antibody; IL-11R-alpha antibody; IL-11RA [Cleaved into: Soluble interleukin-11 receptor subunit alpha antibody; sIL-11R antibody; sIL-11RA antibody; sIL11RA] antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human IL11RA protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number.; Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.; Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling.
  • 基因功能參考文獻：
    1. The results presented here reveal an additional function in classic IL-11 signaling, highlighting the importance of the IL-11R stalk in IL-11 signaling PMID: 29523682
    2. The D2 domain of the IL-11R contains two N-linked glycans, which are dispensable for its biological activity, but differentially control maturation and intracellular trafficking of the receptor. PMID: 29533934
    3. High IL11RA expression is associated with endometrioid tumours. PMID: 28186993
    4. Report IL11RA and MELK amplification in gastric cancer cell lines and primary gastric adenocarcinomas. PMID: 27920471
    5. These results indicate that IL-11Ralpha is a potential target for the development of molecular targeted therapy and noninvasive tumor imaging in human osteosarcoma. PMID: 25524575
    6. IL11RA promoter polymorphism--rs1061758--may be associated with the risk of papillary thyroid cancer in the Korean population. PMID: 21982075
    7. data suggest that IL-11Ralpha-CAR T cells may represent a new therapy for patients with osteosarcoma pulmonary metastases PMID: 22075555
    8. IL11 as well as IL11RA are likely to play a role in the progression of endometrial carcinoma. PMID: 20553623
    9. IL-11Ralpha was expressed in both epithelial and stromal cells, with epithelial staining being more intense PMID: 12200462
    10. the interleukin-11 receptor alpha-chain has evidence of antiapoptotic effects in human colonic epithelial cells PMID: 14701802
    11. IL-11Ralpha is a candidate target for translational clinical trials against advanced and metastatic prostate cancer. PMID: 14744752
    12. interleukin-11 receptor is expressed in CD38-positive cells from patients with multiple myeloma PMID: 15512823
    13. High expression of interleukin-11 receptor alpha is associated with Hodgkin's lymphoma PMID: 16291580
    14. High interleukin 11 receptor is associated with breast cancer PMID: 16614887

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  • 相關(guān)疾?。?/div>
    Craniosynostosis and dental anomalies (CRSDA)
  • 亞細胞定位：
    [Interleukin-11 receptor subunit alpha]: Membrane; Single-pass type I membrane protein.; [Soluble interleukin-11 receptor subunit alpha]: Secreted.; [Isoform HCR2]: Secreted.
  • 蛋白家族：
    Type I cytokine receptor family, Type 3 subfamily
  • 組織特異性：
    Expressed in a number of cell lines, including the myelogenous leukemia cell line K-562, the megakaryocytic leukemia cell line M-07e, the erythroleukemia cell line TF-1, and the osteosarcoma cell lines, MG-63 and SaOS-2. Also expressed in normal and malig
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5967

    OMIM: 600939

    KEGG: hsa:3590

    STRING: 9606.ENSP00000326500

    UniGene: Hs.591088



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