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  4. IGSF8 (GV20-0251 Biosimilar) Recombinant Monoclonal Antibody

IGSF8 (GV20-0251 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA856887MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    IGSF8 (GV20-0251 Biosimilar Antibody)重組單克隆抗體是一款專為生命科學(xué)研究設(shè)計(jì)的高質(zhì)量生物試劑。該產(chǎn)品基于重組DNA技術(shù)制備，具有高純度、高特異性和批次間一致性的特點(diǎn)，為科研人員提供可靠的實(shí)驗(yàn)工具。 作為針對IGSF8靶點(diǎn)的單克隆抗體，該試劑可廣泛應(yīng)用于多種實(shí)驗(yàn)場景，包括但不限于蛋白質(zhì)印跡等。其高度特異性結(jié)合能力確保了實(shí)驗(yàn)結(jié)果的準(zhǔn)確性和可重復(fù)性，有助于研究人員深入探索IGSF8在細(xì)胞信號傳導(dǎo)、免疫調(diào)節(jié)及疾病發(fā)生發(fā)展中的分子機(jī)制。 產(chǎn)品采用嚴(yán)格的質(zhì)量控制標(biāo)準(zhǔn)，通過多步純化工藝去除雜質(zhì)，并經(jīng)過一系列功能性驗(yàn)證，確保抗體活性和穩(wěn)定性。每批次產(chǎn)品均提供詳細(xì)的質(zhì)量檢測報(bào)告，包括蛋白濃度、純度分析、內(nèi)毒素水平及特異性驗(yàn)證數(shù)據(jù)，滿足科研實(shí)驗(yàn)的嚴(yán)格要求。 該重組單克隆抗體的研發(fā)旨在支持基礎(chǔ)醫(yī)學(xué)和轉(zhuǎn)化醫(yī)學(xué)研究，為IGSF8相關(guān)的生物學(xué)功能研究、疾病模型構(gòu)建及藥物靶點(diǎn)發(fā)現(xiàn)提供有力支持。其穩(wěn)定的性能和可靠的品質(zhì)使其成為科研實(shí)驗(yàn)室進(jìn)行相關(guān)研究的理想選擇，助力推動生命科學(xué)領(lǐng)域的探索與創(chuàng)新。
  • Uniprot No.：
  • 基因名：
  • 別名：
    GV20 0251 research-grade biosimilar; XBH25 research-grade biosimilar ;IGSF8 antibody; CD81P3 antibody; EWI2 antibody; KCT4 antibody; Immunoglobulin superfamily member 8 antibody; IgSF8 antibody; CD81 partner 3 antibody; Glu-Trp-Ile EWI motif-containing protein 2 antibody; EWI-2 antibody; Keratinocytes-associated transmembrane protein 4 antibody; KCT-4 antibody; LIR-D1 antibody; Prostaglandin regulatory-like protein antibody; PGRL antibody; CD antigen CD316 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human IGSF8 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
  • 基因功能參考文獻(xiàn)：
    1. EWI-2 negatively regulates TGF-beta signaling and its downstream events including cytostasis (in vitro and in vivo), EMT-like changes, cell migration, CD271-dependent invasion, and lung metastasis (in vivo). PMID: 25656846
    2. Authors demonstrated that EWI-2wint promotes CD81 clustering and confinement in CD81-enriched areas. PMID: 23351194
    3. The EWI-2/alpha-actinin complex is involved in regulation of the actin cytoskeleton at T cell immune and virological synapses, providing a link between membrane microdomains and the formation of polarized membrane structures involved in T cell recognition. PMID: 22689882
    4. analysis of interacting regions of CD81 and two of its partners, EWI-2 and EWI-2wint, and their effect on hepatitis C virus infection PMID: 21343309
    5. EWI2/PGRL associates with the metastasis suppressor KAI1/CD82 and inhibits the migration of prostate cancer cells. PMID: 12750295
    6. EWI-2-dependent reorganization of alpha4beta1-CD81 complexes on the cell surface is responsible for EWI-2 effects on integrin-dependent morphology and motility functions PMID: 15070678
    7. EWI proteins EWI-2 and EWI-F, alpha3beta1 and alpha6beta4 integrins, and protein palmitoylation have contrasting effects on cell surface CD9 organization PMID: 16537545
    8. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins PMID: 16690612
    9. Important functions of recently activated dendritic cells are thus critically modulated by the newly discovered HSPA8-EWI-2 interaction. PMID: 17785435
    10. CD81 partner EWI-2wint inhibits hepatitis C virus entry [EWI-2wint] PMID: 18382656
    11. EWI-2 causes a substantial molecular reorganization of multiple molecules known to affect proliferation and/or invasion of astrocytes and/or glioblastomas. PMID: 19107234

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass membrane protein.
  • 組織特異性：
    Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17813

    OMIM: 606644

    KEGG: hsa:93185

    STRING: 9606.ENSP00000316664

    UniGene: Hs.332012



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