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IGHE (Ligelizumab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號:
    CSB-RA16849MB1HU
  • 規(guī)格:
    ¥83486
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    IGHE(Ligelizumab Biosimilar Antibody)重組單克隆抗體是一款以重組人IGHE蛋白開發(fā),其核心靶點為免疫球蛋白重鏈恒定區(qū)ε(Immunoglobulin heavy constant epsilon),亦被稱為Ig epsilon chain C region或Ig epsilon chain C region ND,簡稱為IGHE。該抗體具有高度的人源種屬反應性,專門針對人類IGHE蛋白設計,為相關疾病的機制研究與臨床轉(zhuǎn)化提供了精準工具。 Ligelizumab作為原研藥物主要聚焦于IgE介導的過敏性疾病。其作用機制是通過特異性結(jié)合游離IgE,阻斷其與肥大細胞、嗜堿性粒細胞表面高親和力受體(FcεRI)的結(jié)合,從而抑制過敏介質(zhì)釋放,緩解哮喘、慢性自發(fā)性蕁麻疹等疾病的急性發(fā)作與慢性進展。目前,多項臨床研究正在評估其在中重度過敏性疾病患者中的療效與安全性,尤其關注長期用藥的安全性和劑量優(yōu)化方案,旨在為患者提供更經(jīng)濟、可及的治療選擇。 該抗體憑借對人IGHE的高度特異性,成為過敏性疾病機制研究的關鍵工具。研究人員可利用其在細胞模型中阻斷IgE-FcεRI信號通路,探索過敏反應的分子調(diào)控網(wǎng)絡;在動物模型中(如人源化IgE小鼠),通過靶向干預評估IGHE在炎癥級聯(lián)反應中的作用。此外,其重組表達特性確保了批次間的穩(wěn)定性,適合用于ELISA實驗檢測樣本中的IGHE水平,或通過免疫沉淀技術定位IGHE在組織與細胞中的分布,為揭示過敏性疾病的發(fā)病機制及開發(fā)新型靶向療法提供實驗基礎。
  • Uniprot No.:
  • 基因名:
  • 別名:
    Immunoglobulin heavy constant epsilon;Ig epsilon chain C region;Ig epsilon chain C region ND , IGHE
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human IGHE protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    0.01M PBS,pH7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用說明:
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    In stock
  • 用途:
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能:
    Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens. The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen.
  • 亞細胞定位:
    Secreted. Cell membrane.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 5522

    OMIM: 147180



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