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  4. HHLA2 (HBM-1020 Biosimilar) Recombinant Monoclonal Antibody

HHLA2 (HBM-1020 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA891555MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    HHLA2（HBM-1020 Biosimilar Antibody)重組單克隆抗體是一種用于生命科學(xué)研究的生物試劑。該產(chǎn)品通過基因工程技術(shù)制備，具有高特異性和批次一致性，為科研人員提供可靠的研究工具。 作為重組單克隆抗體，HHLA2（HBM-1020）針對(duì)特定靶點(diǎn)設(shè)計(jì)，可用于多種實(shí)驗(yàn)應(yīng)用，包括。其高度純化的特性確保了實(shí)驗(yàn)結(jié)果的準(zhǔn)確性和可重復(fù)性，適用于基礎(chǔ)研究和藥物開發(fā)前期的靶點(diǎn)驗(yàn)證。 該抗體的研發(fā)遵循嚴(yán)格的質(zhì)量控制標(biāo)準(zhǔn)，確保產(chǎn)品的生物活性和結(jié)構(gòu)穩(wěn)定性。通過先進(jìn)的表達(dá)系統(tǒng)和純化工藝，HHLA2（HBM-1020）具有低內(nèi)毒素水平和高結(jié)合活性，能夠滿足不同實(shí)驗(yàn)體系的需求。 在科研應(yīng)用中，HHLA2（HBM-1020）可助力研究人員深入探索相關(guān)蛋白質(zhì)的功能、調(diào)控機(jī)制及其在生理和病理過程中的作用。其特異性結(jié)合能力為蛋白質(zhì)相互作用研究、信號(hào)通路分析等提供了有力支持，有助于推動(dòng)免疫學(xué)、腫瘤學(xué)等領(lǐng)域的基礎(chǔ)研究進(jìn)展。 本產(chǎn)品僅供科研使用，不適用于臨床診斷或治療用途。研究人員應(yīng)根據(jù)具體實(shí)驗(yàn)需求，按照標(biāo)準(zhǔn)操作流程進(jìn)行稀釋和使用，以獲得最佳實(shí)驗(yàn)效果。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Anti-B7H7 monoclonal antibody - Harbour BioMed research-grade biosimilar; HBM 1020 research-grade biosimilar; HBM-1020 research-grade biosimilar ;HHLA2 antibody; HERV-H LTR-associating protein 2 antibody; Human endogenous retrovirus-H long terminal repeat-associating protein 2 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human HHLA2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
  • 基因功能參考文獻(xiàn)：
    1. HHLA2 protein expression was evaluated in primary tumor specimens and metastatic disease using an osteosarcoma tumor microarray. HHLA2 was expressed in almost all metastatic disease specimens and was more prevalent than in primary specimens without known metastases. PMID: 27531281
    2. HHLA2 was not detected in most of normal lung tissue but expressed in 66% of NSCLC across different subtypes. In particular, EGFR-mutated NSCLC was significantly associated with higher tumor HHLA2 expression in both discovery and validation lung cancer cohorts. HHLA2 is widely expressed in NSCLC and is associated with EGFR mutation and high TILs in lung adenocarcinoma. PMID: 27553831
    3. Low B7-H5 expression is associated with pancreatic adenocarcinomas. PMID: 25519928
    4. The HHLA2 pathway represents a novel immunosuppressive mechanism within the tumor microenvironment. PMID: 25549724
    5. B7 homologue 5 (B7-H5), was identified as a specific ligand for CD28H PMID: 23784006
    6. Data indicate that HHLA2 protein was predominantly found on cell membranes with some in the cytoplasm. PMID: 23716685

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  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed at high levels in colon, kidney, testis, lung and pancreas, and at lower levels in small intestine, liver and skeletal muscle. In immune cells, highly expressed in B-cells, dendritic cells and macrophages. Not detected in T-cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4905

    OMIM: 604371

    KEGG: hsa:11148

    STRING: 9606.ENSP00000350402

    UniGene: Hs.225968



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