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  4. HAVCR1 (CDX014 Biosimilar) Recombinant Monoclonal Antibody

HAVCR1 (CDX014 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA010144MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    HAVCR1（CDX014 Biosimilar Antibody）重組單克隆抗體是一種針對人類肝病毒A細胞受體1（HAVCR1），其別名為CD365抗體、HAVCR 1抗體、Kidney injury molecule 1（KIM-1）抗體、T細胞免疫球蛋白黏蛋白家族成員1（TIM-1）抗體等。該抗體以重組人HAVCR1蛋白制備，具有高度的種屬反應(yīng)性，專門針對人類HAVCR1蛋白發(fā)揮作用。 HAVCR1作為一種跨膜糖蛋白，在腎臟損傷、炎癥性疾病及腫瘤等多種病理過程中扮演重要角色。研究表明，針對HAVCR1（KIM-1）類似物在急性腎損傷時可通過靶向該蛋白表達變化，為評估腎損傷程度提供潛在診斷依據(jù)或開發(fā)靶向治療藥物。此外，針對HAVCR1（TIM-1）類似物在免疫調(diào)節(jié)中作用關(guān)鍵，其通過調(diào)控T細胞活性參與自身免疫性疾病和過敏性疾病的治療，為自身免疫病治療提供了新方向。同時，針對HAVCR1類似物在多種腫瘤組織中可靶向其異常高表達，可能與抑制腫瘤細胞增殖、侵襲及轉(zhuǎn)移相關(guān)，有望用于腫瘤靶向治療或預(yù)后評估。 HAVCR1重組單克隆抗體是研究HAVCR1蛋白功能的重要工具。它特異性檢測HAVCR1在細胞或組織中的表達水平及定位；通過免疫沉淀等技術(shù)，可探究HAVCR1與其他蛋白質(zhì)的相互作用，揭示其參與的信號通路機制。此外，該抗體還可用于構(gòu)建HAVCR1基因敲除或過表達細胞模型，深入研究其在生理及病理條件下的功能，為相關(guān)疾病的發(fā)病機制研究和藥物開發(fā)提供實驗基礎(chǔ)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CD365 antibody; HAVCR 1 antibody; HAVCR antibody; HAVcr-1 antibody; Havcr1 antibody; Hepatitis A virus cellular receptor 1 antibody; Kidney injury molecule 1 antibody; KIM 1 antibody; KIM-1 antibody; T cell immunoglobin domain and mucin domain protein 1 antibody; T cell immunoglobulin mucin family member 1 antibody; T cell immunoglobulin mucin receptor 1 antibody; T-cell immunoglobulin and mucin domain-containing protein 1 antibody; T-cell membrane protein 1 antibody; TIM antibody; TIM-1 antibody; TIM1 antibody; TIMD 1 antibody; TIMD-1 antibody; TIMD1 antibody; TIMD1_HUMAN antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human HAVCR1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair.; (Microbial infection) Acts as a receptor for Hepatitis A virus.; (Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane. Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP.; (Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane.; (Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E.
  • 基因功能參考文獻：
    1. neither the inflammatory biomarker calprotectin, nor the tubular biomarkers NGAL and KIM-1, provide robust prognostic information on the loss of renal function in a heterogeneous CKD population. All of them, however, are candidate prognostic biomarkers in primarily inflammatory renal diseases. PMID: 30078006
    2. High KIM1 expression is associated with Clear Cell Renal Cell Carcinoma. PMID: 29295730
    3. Human oligodendrocytes undergo apoptosis when exposed to Sema4A and take up H-ferritin for meeting iron requirements and that these functions are mediated via the Tim-1 receptor. H-ferritin can block Sema4A-mediated cytotoxicity. Sema4A is detectable in the CSF of multiple sclerosis patients and HIV-seropositive persons and can induce oligodendrocyte cell death. PMID: 29457657
    4. Elevated plasma NT-proBNP and KIM-1 in patients with stage 5 chronic kidney disease (CKD5) undergoing maintenance hemodialysis (HD) and HF (+) (heart failure)CKD5-HD patients suggest that natriuretic peptides and KIM-1 may contribute to the pathogenesis of HF in CKD5-HD patients. PMID: 28990414
    5. These findings suggest that the TIMD4-HAVCR1 variants may be the genetic risk factors for coronary heart disease and ischemic strok PMID: 29208769
    6. These studies provide evidence that, in the absence of a functional alpha-dystroglycan, TIM-1 mediates the entry of Lassa virus pseudoviral particles through interactions of virions with the IgV PtdSer-binding pocket of TIM-1. PMID: 29875238
    7. total flavone of Desmodium styracifolium inhibited HK-2 cell apoptosis and autophagy by regulating KIM-1 via p38/MAPK pathway. PMID: 29071538
    8. Polymorphism +4259A>C in exon 3 of the TIM-3 gene is associated with susceptibility to multiple sclerosis but polymorphism -1637C>T in the promoter region of TIM-1 is not. PMID: 29141799
    9. High KIM1 expression is associated with decreased proximal tubular epithelial cell function. PMID: 29045706
    10. findings show that TIM1 is not an essential cellular receptor for hepatitis A virus entry into cultured cells PMID: 28874468
    11. Urinary excretion of KIM-1 correlates with blood lead levels better than other traditional renal injury biomarkers, including N-acetyl-beta-(D)-glucosaminidase, alpha1-microglobulin, and beta2-microglobulin. PMID: 27966578
    12. promising results were obtained for circulating KIM-1 prediction of renal outcomes in type 1 diabetes--{REVIEW} PMID: 27771693
    13. data show that in addition to the phospholipid-binding function of HAVCR1, the enhancement of HCV infection involves other determinants in the IgV domain of HAVCR1. These findings expand the repertoire of molecules that HCV uses for cell entry, adding to the already complex mechanism of HCV infection and pathogenesis. PMID: 29321304
    14. Review/Meta-analysis: suggest that TIM-1-416G[C single nucleotide polymorphism is associated with the risk of asthma for the Asian ethnicity in the codominant (G/G vs. G/C) and dominant (G/G vs. G/C + C/C) genetic models. PMID: 28434117
    15. Urinary NGAL is a good predictor of mortality in established pediatric acute kidney injury (AKI) of heterogeneous etiology and outperforms calprotectin and KIM-1. Urinary calprotectin and KIM-1 predict renal replacement therapy requirement in pediatric AKI. PMID: 28409285
    16. A panel consisting of IGFBP1, KIM1, GCLC and GSTM1 genes could be used in combination for early screening of CKDu, whereas these genes in addition with FN1, IGFBP3 and KLK1 could be used to monitor progression of CKDu. The regulation of these genes has to be studied on larger populations to validate their efficiency for further clinical use. PMID: 28103909
    17. Quantification of TIM-3 and KIM-1 mRNA expressions, along with KIM-1 protein measurements in urine and blood could be employed as promising tools for noninvasive diagnosis of allograft dysfunction. PMID: 28757398
    18. Report detection of drug-induced acute kidney injury in humans by combining the sensitivity of urinary KIM-1 along with urinary miR-21, -200c, and -423. PMID: 27122240
    19. measurement of urinary and renal KIM-1 level may be helpful to evaluate severity of renal pathological damage and prognosis in adult Henoch-Schonlein purpura patients with nephritis PMID: 29122357
    20. Urine KIM-1 level in acute kidney injury patients was significantly higher than that in the healthy controls. PMID: 28212617
    21. PCNSL is characterized by frequent Tim-1 expression, and its soluble form in CSF may become a useful biomarker for PCNSL. PMID: 27709813
    22. TIM-1 is a unique marker for the identification of a human IL-10(+) Breg subpopulation which is partially superimposed with transitional B cells PMID: 28103916
    23. in the current meta-analysis, based on ten prospective studies involving 29366 participants, we evaluated the role of urinary tubular injury markers (NGAL, KIM-1 and NAG) in predicting clinical outcomes including CKD stage 3, end stage renal disease and mortality. PMID: 27907168
    24. Urinary KIM-1 levels in the acute kidney injury (AKI) preterm infant group were not significantly higher than in no-AKI group on day of life 1, 3 and 7. PMID: 27020372
    25. We conclude that KIM-1 might serve as a sensitive biomarker to screen children for kidney damage induced by environmental toxic agents, such as chromium and arsenic PMID: 27431456
    26. These results suggest that a 6-amino acid deletion polymorphism in the mucin domain of TIM-1 protects from HIV-1 infection with a recessive effect. PMID: 27652980
    27. The present study shows that serum and urine levels of NGAL and KIM-1 are higher in patients with acute kidney injury than in those without acute kidney injury, and that serum NGAL and the presence of chronic kidney disease are significant predictors of acute kidney injury in scrub typhus. PMID: 28419138
    28. KIM-1 increases albumin endocytosis in renal tubule epithelial cells. PMID: 26332568
    29. preliminary data indicates that KIM-1 expression may be associated with stage in Wilms Tumor PMID: 27562389
    30. Urinary KIM-1 and NAG levels were positively correlated. PMID: 27272162
    31. TLR2, Tim1, Tim3, TNF-alpha, IgE and EOS play a role in Mycoplasma pneumoniae Pneumonia-related wheezing in children. PMID: 27185658
    32. The results of our study showed that there is no significant association between TIM-1 5383-5397ins/del and Multiple sclerosis (MS) (P = 0.38); however, the frequency of CT genotype of TIM-3 -1541C>T in patient group was significantly higher than the control group, and there was a significant association between CT genotype and MS PMID: 27091308
    33. Study emphasizes a strong association of the tubular biomarker KIM-1 with chronic kidney disease progression in chronic heart failure and suggests usefulness as cardiorenal marker. PMID: 26422793
    34. KIM-1 expression also enhances ERK MAPK activation, and the modulatory effect of KIM-1 on cellular repair process is likely mediated via ERK MAPK signaling pathway. PMID: 27084535
    35. KIM-1 may mediate high glucose-induced autophagy and apoptosis in renal tubular epithelial cells. PMID: 27310004
    36. Study suggests that TIM1 -416G>C and -1454G>A single nucleotide polymorphisms are associated with dilated cardiomyopathy susceptibility and prognosis in this Han Chinese population. PMID: 27818477
    37. elevated baseline plasma KIM-1 strongly associated with risk of early progressive renal decline in type 1 diabetes PMID: 26509588
    38. Urinary KIM-1 levels increased significantly in patients with contrast-induced nephropathy. PMID: 26474236
    39. Data show that kidney injury molecule (KIM)-1 and neutrophil gelatinase-associated lipocalin (NGAL), were significantly elevated in welding workers post-exposure. PMID: 26673824
    40. High NGAL and KIM-1 levels may indicate early diabetic kidney injury; however, we did not observe any relationship between these markers and diabetic indices PMID: 26393328
    41. Kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin excretion rates correlated with excretion rates of other tubular damage markers and predicted outcome in patients with idiopathic membranous nephropathy PMID: 25762211
    42. The aim of this review article is to summarize the literature data concerning KIM-1 as a potential novel marker in the early diagnosis and prediction of clinical outcome of certain cardiovascular diseases. PMID: 26697493
    43. Activation of TIM1 by exposing the cells to TIM4 significantly increased the frequency of apoptotic colon cancer cells. The expression of FasL was increased in the cancer cells after treating by TIM4. PMID: 26921445
    44. Urine KIM1 level was higher in kidney stone patients before lithotripsy than in healthy controls. PMID: 26407192
    45. Urinary levels of NGAL are more sensitive than uKIM-1 and uL-FABP levels in predicting renal scarring in vesicoureteral reflux. PMID: 26324091
    46. TIM-1 ligands increase the amount of cell surface protein, preventing its traffic to the immune synapse PMID: 26332704
    47. Urinary KIM-1 measured 24 h after the start of drug infusion has the potential to detect early AKI in pediatric patients treated with MTX or platinum-class drugs PMID: 26248472
    48. Urinary KIM-1 is a significant predictor of death in extremely low-birth-weight neonates. PMID: 26107391
    49. Urinary KIM1 is significantly higher in patients with clear cell renal carcinoma than in controls. Urinary KIM1 decreases after nephrectomy in clear cell renal carcinoma patients. PMID: 27295912
    50. decreased serum TIM-1 and TIM-3 levels and association of TIM-3 with nephritis suggest their possible role in the development and pathogenesis of systemic lupus erythematosus. PMID: 27049082

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, TIM family
  • 組織特異性：
    Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 17866

    OMIM: 606518

    KEGG: hsa:26762

    STRING: 9606.ENSP00000344844

    UniGene: Hs.129711



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