HAP1 (Calpurbatug Biosimilar) Recombinant Monoclonal Antibody
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貨號:CSB-RA010129MB1HU
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規(guī)格:¥83486
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其他:
產(chǎn)品詳情
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產(chǎn)品描述:HAP1 (Calpurbatug Biosimilar Antibody)重組單克隆抗體是一種用于科研領(lǐng)域的生物制劑,通過重組DNA技術(shù)制備而成,具有高度特異性和均一性。該抗體針對特定靶標設(shè)計,能夠精準識別并結(jié)合生物樣本中的目標分子,為生命科學研究提供可靠的工具支持。 在基礎(chǔ)研究中,HAP1 (Calpurbatug Biosimilar Antibody)重組單克隆抗體可用于蛋白質(zhì)定位、相互作用分析及信號通路研究等方向。其高親和力特性有助于提高檢測靈敏度,適用于等多種實驗方法。同時,該抗體的批次間一致性能夠有效減少實驗誤差,保障研究結(jié)果的可重復性。 在藥物研發(fā)相關(guān)科研中,HAP1 (Calpurbatug Biosimilar Antibody)重組單克隆抗體可作為靶點驗證、藥效評估的重要工具,助力探索疾病機制及潛在治療方案。其重組表達體系確保了生產(chǎn)過程的可控性,可根據(jù)研究需求提供不同規(guī)格產(chǎn)品,滿足各類實驗場景的應用需求。 該產(chǎn)品僅用于科研用途,不可用于臨床診斷或治療。使用時需嚴格遵循實驗操作規(guī)范,結(jié)合具體研究目的進行合理稀釋和實驗設(shè)計,以充分發(fā)揮其在生命科學研究中的應用價值。
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Uniprot No.:
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基因名:
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別名:TRL1068 research-grade biosimilar; TRL 1068 research-grade biosimilar; TRL-1068 research-grade biosimilar ;HAP1 antibody; HAP2 antibody; HLP1 antibody; Huntingtin-associated protein 1 antibody; HAP-1 antibody; Neuroan 1 antibody
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反應種屬:Human
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免疫原:Recombinant Human HAP1 protein
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免疫原種屬:Homo sapiens (Human)
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標記方式:Non-conjugated
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克隆類型:Monoclonal
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濃度:It differs from different batches. Please contact us to confirm it.
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保存緩沖液:0.01M PBS,pH7.4
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產(chǎn)品提供形式:Liquid
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應用說明:Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method. -
儲存條件:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期:3-4 weeks
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用途:It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.
相關(guān)產(chǎn)品
靶點詳情
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功能:Originally identified as neuronal protein that specifically associates with HTT/huntingtin and the binding is enhanced by an expanded polyglutamine repeat within HTT possibly affecting HAP1 interaction properties. Both HTT and HAP1 are involved in intracellular trafficking and HAP1 is proposed to link HTT to motor proteins and/or transport cargos. Seems to play a role in vesicular transport within neurons and axons such as from early endosomes to late endocytic compartments and to promote neurite outgrowth. The vesicular transport function via association with microtubule-dependent transporters can be attenuated by association with mutant HTT. Involved in the axonal transport of BDNF and its activity-dependent secretion; the function seems to involve HTT, DCTN1 and a complex with SORT1. Involved in APP trafficking and seems to facilitate APP anterograde transport and membrane insertion thereby possibly reducing processing into amyloid beta. Involved in delivery of gamma-aminobutyric acid (GABA(A)) receptors to synapses; the function is dependent on kinesin motor protein KIF5 and is disrupted by HTT with expanded polyglutamine repeat. Involved in regulation of autophagosome motility by promoting efficient retrograde axonal transport. Seems to be involved in regulation of membrane receptor recycling and degradation, and respective signal transduction, including GABA(A) receptors, tyrosine kinase receptors, EGFR, IP3 receptor and androgen receptor. Among others suggested to be involved in control of feeding behavior (involving hypothalamic GABA(A) receptors), cerebellar and brainstem development (involving AHI1 and NTRK1/TrkA), postnatal neurogenesis (involving hypothalamic NTRK2/TrkB), and ITPR1/InsP3R1-mediated Ca(2+) release (involving HTT and possibly the effect of mutant HTT). Via association with DCTN1/dynactin p150-glued and HTT/huntingtin involved in cytoplasmic retention of REST in neurons. May be involved in ciliogenesis. Involved in regulation of exocytosis. Seems to be involved in formation of cytoplasmic inclusion bodies (STBs). In case of anomalous expression of TBP, can sequester a subset of TBP into STBs; sequestration is enhanced by an expanded polyglutamine repeat within TBP. HAP1-containing STBs have been proposed to play a protective role against neurodegeneration in Huntigton disease (HD) and spinocerebellar ataxia 17 (SCA17).
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基因功能參考文獻:
- HAP1 is expressed in endocrine cells of the human gut. PMID: 27737633
- data fully support that HAP1 is a GKAP, anchoring specifically to the cGMP-dependent protein kinase isoform Ibeta, and provide further evidence that also PKG spatiotemporal signaling is largely controlled by anchoring proteins PMID: 25653285
- The -141 T > G polymorphism, but not the 1349 T > G polymorphism, may have protective effects for lung cancer. PMID: 25081373
- HAP1 gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity PMID: 25446120
- Overexpression of HAP1 reduced in vitro cell growth in breast cancer cell lines. PMID: 23440330
- The results of this study found no association was found between the HAP1 T441M polymorphism and the age at onset of Huntington's disease . PMID: 22698993
- The results of this study suggested that HAP1 co-localizes and associates with APP in physiological conditions of mouse and human brain. PMID: 22731248
- WT HTT regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1). PMID: 21985783
- HAP1/stigmoid body interacts with the normal ataxin-3 through Josephin domain PMID: 21386698
- sortilin stabilizes the proBDNF.HAP1 complex PMID: 21357693
- ADORA2A, but not HAP1 or OGG1, may have a role in age at onset in Huntington's disease PMID: 20512606
- REVIEW: function of HAP1 PMID: 19262167
- HAP1 may participate in axonal transport and activity-dependent release of pro-BDNF by interacting with the BDNF prodomain. PMID: 19996106
- The combination of siRNA, the SB transposon, and an accurate transgenic mouse model may permit evaluation of this approach in preventing the pathogenesis associated with expression of mutant Htt. PMID: 15737634
- Study provides genetic and functional evidence that the M441-HAP1 polymorphism modifies the age-at-onset of Huntington's disease . PMID: 18192679
- REST/NRSF, dynactin p150(Glued), huntingtin, HAP1, and RILP form a complex involved in the translocation of REST/NRSF into the nucleus and HAP1 controls REST/NRSF cellular localization in neurons PMID: 18922795
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亞細胞定位:Cytoplasm. Cell projection, axon. Cell junction, synapse, presynapse. Cytoplasm, cytoskeleton. Cell projection, dendritic spine. Cell projection, dendrite. Lysosome. Endoplasmic reticulum. Mitochondrion. Nucleus. Cytoplasmic vesicle, autophagosome. Early endosome. Cell projection, growth cone. Cell projection, neuron projection. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle.
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組織特異性:Predominantly expressed in brain. Selectively expressed in neurons.
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