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  4. Gipr (US20170275370A1 Biosimilar) Recombinant Monoclonal Antibody

Gipr (US20170275370A1 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA009438MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    Gipr（US20170275370A1 Biosimilar Antibody）重組單克隆抗體，其靶向的胃抑制多肽受體（Gastric inhibitory polypeptide receptor，簡稱GIP-R，別名還包括Glucose-dependent insulinotropic polypeptide receptor、Gipr）是一種在代謝調(diào)節(jié)中具有重要作用的G蛋白偶聯(lián)受體。該抗體以重組人Gipr蛋白制備而成，具有明確的種屬反應(yīng)性，可特異性識別并結(jié)合小鼠和大鼠的Gipr蛋白，為相關(guān)動物模型的研究提供了可靠的工具。 針對GIP-R抗體，US20170275370A1的類似物作為代謝疾病治療的潛在手段備受關(guān)注。GIP-R參與調(diào)控胰島素分泌、脂肪細(xì)胞分化及能量代謝等生理過程，其功能異常與2型糖尿病、肥胖癥等代謝紊亂疾病密切相關(guān)。目前，相關(guān)藥物研發(fā)聚焦于開發(fā)激動劑或拮抗劑以改善糖脂代謝，這些候選藥物可通過靶向GIP-R發(fā)揮調(diào)節(jié)代謝的作用，在臨床前研究中已展現(xiàn)出改善血糖控制、減輕體重等潛力，有望為代謝疾病患者提供新的治療選擇。 Gipr抗體憑借對小鼠和大鼠Gipr的高特異性，成為基礎(chǔ)研究中的重要工具。研究者可利用該抗體通過技術(shù)，檢測Gipr在動物組織（如胰腺、脂肪、大腦等）中的表達(dá)定位與豐度變化，揭示其在生理及病理狀態(tài)下的分布規(guī)律；同時，結(jié)合或共沉淀實驗，可深入探究Gipr與其他信號分子的相互作用，解析其下游信號通路的調(diào)控網(wǎng)絡(luò)。此外，在基因編輯動物模型（如Gipr敲除小鼠）的驗證實驗中，該抗體可用于確認(rèn)受體表達(dá)的缺失或突變，為代謝相關(guān)基因功能研究提供有力支持。其種屬反應(yīng)性的明確性，也確保了實驗結(jié)果在嚙齒類模型中的可靠性與可重復(fù)性，推動代謝調(diào)控機(jī)制、肥胖與糖尿病發(fā)病機(jī)理等領(lǐng)域的研究進(jìn)展。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Gastric inhibitory polypeptide receptor; GIP-R; Glucose-dependent insulinotropic polypeptide receptor; Gipr
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Gipr protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
  • 基因功能參考文獻(xiàn)：
    1. The study provides evidence that the insulinotropic action of zfGIP in mammalian systems involves activation of both the GLP-1 and the GIP receptors but not the glucagon receptor PMID: 29157578
    2. Microarray analysis revealed that pregnancy-specific glycoprotein 17 (Psg17), a potential CD9-binding partner, was significantly decreased in GIP receptor-knockout (Gipr-/-) testes. PMID: 28430907
    3. GIPR signaling in adipose tissue plays a critical role in high fat diet-induced insulin resistance and hepatic steatosis in vivo, which may involve IL-6 signaling. PMID: 28096257
    4. Genetic deletion of both GLP-1 and GIP receptors reveals that they are required to maintain an adequate islet number in adulthood and to maintain normal beta cell responses to glucose. PMID: 27020250
    5. Results suggest the beneficial effects of glucose-dependent insulinotropic polypeptide on periodontal disease. PMID: 27181102
    6. Gipr(-/-) offspring of mice exposed to high fat diet(HFD) during pregnancy/lactation became insulin resistant and obese and exhibited increased adipose tissue inflammation and decreased peripheral tissue substrate utilization after reintroduction of HFD. PMID: 26631738
    7. Beta-cell Gipr KO mice exhibit lower levels of meal-stimulated insulin secretion, decreased expansion of adipose tissue mass and preservation of insulin sensitivity and decreased TCF1 expression. PMID: 26642437
    8. Gipr is expressed in healthy arteries, predominantly in endothelial cells. PMID: 26395740
    9. These data highlighted the importance of intact GIPR signalling and dietary composition in modulating memory and learning, and hippocampal pathways involved in the maintenance of synaptic plasticity PMID: 25760229
    10. Functional GIP receptors play a major role in islet compensatory response to high fat feeding in mice. PMID: 25688757
    11. our data demonstrate that the expression of GLP-1R and GIPR is regulated by glucose concentrations in MC3T3-E1 cells undergoing differentiation induced by BMP-2. PMID: 24866833
    12. Results show that GIPR undergoes trafficking between the plasma membrane and intracellular compartments of both GIP-stimulated and unstimulated adipocytes. PMID: 25047836
    13. Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor. PMID: 23689510
    14. a role of the adipocyte GIPr in nutrient-dependent regulation of body weight and lean mass, but it does not support a direct and independent role for the adipocyte or beta-cell GIPr in promoting adipogenesis. PMID: 22027838
    15. Gipr is essential for adrenal steroidogenesis and links high fat (HF) feeding to increased levels of corticosterone, reduced glucocorticoid levels do not significantly contribute to the enhanced metabolic phenotypes in HF-fed Gipr(-/-) mice. PMID: 22043004
    16. GIPR(dn) transgenic mice show a disturbed expansion of the endocrine pancreas, due to perturbed islet neogenesis. PMID: 21818396
    17. GIP receptors play an important role in cognition, neurotransmission, and cell proliferation. PMID: 21273318
    18. Both GIPR protein and mRNA expression increased during cell differentiation, and this increase was associated with upregulation of nuclear levels of SREBP-1c and PPARgamma, as well as acetylation of histones H3/H4. PMID: 21245029
    19. GIPR(-/-) mice exhibit altered islet structure and topography and increased islet sensitivity to glucagon-like peptide-1 despite a decrease in pancreatic insulin content and gene expression PMID: 12540373
    20. Results demonstrate that glucose intolerance was additively increased during oral glucose absorption when both gastric inhibitory polypeptide receptors and glucagon-like peptide 1 receptors were inactivated. PMID: 14966573
    21. intact signaling of G-protein coupled receptors is involved in postnatal islet and beta-cell development and neogenesis of the pancreatic islets PMID: 15582721
    22. Adult GIP receptor knock-out mice exhibit a significantly lower number of newborn cells in the hippocampal dentate gyrus compared with wild-type mice. PMID: 15716418
    23. long term activation of the GIP receptor by daily treatment with N-AcGIP(LysPAL37) improved glucose tolerance due to enhancement of pancreatic beta cell glucose responsiveness and insulin secretion. PMID: 16181707
    24. Both incretins secretion depends on mechanisms involving their own receptors and GLP-1 further requires GLUT2. PMID: 17681422
    25. relative reduction of truncated GIPR expression may be involved in hypersensitivity of GIPR and hyperinsulinemia in diet-induced obese mice PMID: 17971513
    26. Double incretin receptor knockout mice exhibit enhanced insulin action compared with wild-type mice when fed a regular diet and are protected from high-fat diet-induced obesity and insulin resistance. PMID: 17977951
    27. Gastric inhibitory peptide receptor interacts with estrogens in the hypothalamic regulation of food intake in mice. PMID: 18505834
    28. Results suggest that activation of the gastric inhibitory polypeptide receptor can improve diabetes control in high-fat-fed mice. PMID: 19073224
    29. Analyses with GIPR-deficient mice suggest a role of GIP/GIPR signal transduction in promoting spontaneous recovery after nerve crush; injury of GIPR-deficient mouse sciatic nerve revealed impaired axonal regeneration. PMID: 19170165
    30. Report differential importance of glucose-dependent insulinotropic polypeptide vs glucagon-like peptide 1 receptor signaling for beta cell survival in mice. PMID: 19766644

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family
  • 數(shù)據(jù)庫鏈接：


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