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GUCY2C (indusatumab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào):
    CSB-RA010053MB1HU
  • 規(guī)格:
    ¥83486
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品描述:
    GUCY2C(indusatumab Biosimilar Antibody)重組單克隆抗體是一種針對(duì)人鳥苷酸環(huán)化酶C(GUCY2C),其靶點(diǎn)GUCY2C又稱熱穩(wěn)定腸毒素受體(Heat-stable enterotoxin receptor)、腸道鳥苷酸環(huán)化酶(Intestinal guanylate cyclase)等,在人體組織中具有特異性表達(dá)。該抗體以重組人GUCY2C蛋白制備,具有明確的人源種屬反應(yīng)性,為靶向GUCY2C的相關(guān)研究與應(yīng)用提供了特異性工具。 indusatumab Biosimilar Antibody作為靶向GUCY2C抗體,indusatumab類似物,因GUCY2C在結(jié)直腸癌、胰腺癌等多種消化道腫瘤中高表達(dá)而具有治療潛力。indusatumab有望通過特異性結(jié)合GUCY2C,干擾腫瘤細(xì)胞信號(hào)通路,抑制腫瘤增殖與轉(zhuǎn)移,目前相關(guān)研究正探索其在晚期實(shí)體瘤治療中的療效與安全性,尤其關(guān)注其與化療、免疫治療聯(lián)合應(yīng)用的協(xié)同效應(yīng),為改善消化道腫瘤患者預(yù)后提供新策略。 該抗體可廣泛應(yīng)用于腫瘤生物學(xué)機(jī)制研究,包括通過實(shí)驗(yàn)檢測(cè)GUCY2C在組織樣本中的表達(dá)水平,或利用分析其在腫瘤細(xì)胞表面的分布特征。此外,在細(xì)胞模型構(gòu)建中,該抗體可用于驗(yàn)證GUCY2C作為治療靶點(diǎn)的可行性,助力開發(fā)基于GUCY2C的抗體類似物偶聯(lián)物(ADC)、雙特異性抗體等新型治療藥物,推動(dòng)消化道腫瘤靶向治療的基礎(chǔ)研究與轉(zhuǎn)化醫(yī)學(xué)進(jìn)展。
  • Uniprot No.:
  • 基因名:
  • 別名:
    GC-C; Guanylyl cyclase C; GUC2C; GUC2C_HUMAN; GUCY2C; Heat stable enterotoxin receptor; Heat-stable enterotoxin receptor; hSTAR; Intestinal guanylate cyclase; STA receptor
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human GUCY2C protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    0.01M PBS,pH7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用說(shuō)明:
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    In stock
  • 用途:
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptides guanylin and uroguanylin.
  • 基因功能參考文獻(xiàn):
    1. High Expressions of guanylyl cyclase C is associated with rectal cancer. PMID: 28418917
    2. The findings support that the activating mutation in GUCY2C creates an intestinal environment with a major influence on the microbiota, which could contribute to the increased susceptibility to inflammatory bowel disease in patients with Familial GUCY2C diarrhea syndrome. PMID: 28902124
    3. the expression of GCC is maintained throughout the process of tumor progression and formation of metastatic disease. PMID: 29261789
    4. To investigate gut motility and hormones before and after a meal in Familial GUCY2C diarrhea syndrome patients and compare with healthy controls PMID: 28957388
    5. Mutations in GUCY2C indicate a role for this receptor in the pathogenesis of sporadic Congenital secretory diarrhea. PMID: 25994218
    6. these data support Ad5-GUCY2C-PADRE as a safe and effective vaccination strategy in preclinical models and position Ad5-GUCY2C-PADRE for Phase I clinical testing in colorectal cancer patients. PMID: 27903079
    7. Familial GUCY2C diarrhoea syndrome is caused by an activating mutation in the GUCY2C gene, which causes impaired contractility and fluid stagnation in the small bowel PMID: 27338166
    8. Findings show how caloric suppression of the guanylin-GUCY2C signaling axis links obesity to negation of a universal tumor suppressor pathway in colorectal cancer. PMID: 26773096
    9. Data show that individuals affected with meconium ileus (MI) had either homozygous or compound heterozygous variants in enterotoxin receptor GUCY2C. PMID: 25370039
    10. High guanylyl cyclase C expression is associated with colon cancer recurrence. PMID: 24919572
    11. Transmission disequilibrium tests (TDT), case-control studies and quantitative analyses indicated association between GUC2C with Attention-deficit/hyperactivitydisorder and its core symptoms. PMID: 25064385
    12. Intestinal cell proliferation and senescence are regulated by receptor guanylyl cyclase C and p21. PMID: 24217248
    13. GUCY2C signaling constitutes a direct link between the initiation of colorectal cancer and the induction of its associated desmoplastic stromal niche. PMID: 24085786
    14. Data show that lower survival (OS) and disease-free survival (DFS) rates were significantly associated with guanylate cyclase C (GCC) and CK20 mRNA levels. PMID: 23150200
    15. Interaction with VIP36 is dependent on glycosylation at the same sites that allow GC-C to fold and bind ligand. PMID: 23269669
    16. GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity PMID: 22384056
    17. Mutations in GUCY2C were associated with the Meconium ileus phenotype. downregulation of GUCY2C leads to a cystic fibrosis-like intestinal phenotype. PMID: 22521417
    18. We identified a heterozygous missense mutation (c.2519G-->T) in GUCY2C in all family members with familial diarrhea syndrome. PMID: 22436048
    19. High guanylyl cyclase C is associated with colon cancer. PMID: 21533822
    20. Data suggest that monitoring the peripheral blood GCC expressions may allow employing different treatment options to metastatic CRC patients. PMID: 21901559
    21. Lymph nodes (range: 2-159) from 291 prospectively enrolled node-negative colorectal cancer patients were analyzed by histopathology and GUCY2C quantitative RT-PCR. PMID: 21307149
    22. Longer survival was associated with hypomethylation at specific CpG sites (e.g. GREB1, TGIF and TOB1) and hypermethylation in other genes (e.g. TMCO5, PTPRN and GUCY2C). PMID: 21577013
    23. A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor. PMID: 11950846
    24. guanylyl cyclase c is ectopically expressed in primary and metastatis adenocarcinoma of the esophagus and stomach PMID: 12163327
    25. SH3 domain -mediated protein-protein interaction with the catalytic domain of guanylyl cyclase C inhibited the cyclase activity and might be pivotal for the desensitization phenomenon of the guanylyl cyclase C receptor PMID: 12649275
    26. gelatinolytic activity of GCC in colorectal tumor tissues may facilitate the hepatic metastatic process in the steps after intravasation but not during or before intravasation PMID: 14581363
    27. a novel role for glycosidic modification of GC-C during its biosynthesis, in imparting subtle conformational changes in the receptor that allow for ligand-mediated activation and perhaps regulation of basal activity PMID: 14748740
    28. Lack of guanylyl cyclase c expression assoeciated with significant reduction in adenomas in Apc(Min/+);Gucy2c(-/-) mice PMID: 15825168
    29. Transformation associated with reflux at the gastroesophageal junction reflects activation by bile acid and acid of a transcriptional program involving NF-kappaB and Cdx2, which mediate intestinal metaplasia and ectopic expression of GC-C. PMID: 16618413
    30. This validated assay is being applied to approximately 10,000 lymph nodes in a prospective trial to define the sensitivity of Guanylyl cyclase C(GCC) qRT-PCR for staging patients with colorectal cancer. PMID: 16899600
    31. docking of the c-src SH2 domain to phosphorylated GC-C results in colocalization and further activation of c-src. PMID: 19620276
    32. the role of the linker region in receptor guanylyl cyclases PMID: 19648115
    33. GCC is a specific marker for differentiating primary and secondary metatstatic ovarian mucinous neoplasms. PMID: 19694825
    34. Results suggest that GUCY2C quantitative reverse transcriptase (qRT)-PCR can be used to detect occult lymph node metastases in pN0 colorectal cancer patients. PMID: 19895223
    35. Expression of the receptor guanylyl cyclase C and its ligands in reproductive tissues of the rat: a potential role for a novel signaling pathway in the epididymis. PMID: 12444076
    36. The protein kinase-like domain in receptor guanylyl cyclase C provides a critical structural link between the extracellular domain and the catalytic domain in regulation of this family of receptors. PMID: 11478887

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  • 相關(guān)疾?。?/div>
    Diarrhea 6 (DIAR6); Meconium ileus (MECIL)
  • 亞細(xì)胞定位:
    Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=The 145 kDa plasma membrane form of GC-C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form.
  • 蛋白家族:
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 4688

    OMIM: 601330

    KEGG: hsa:2984

    STRING: 9606.ENSP00000261170

    UniGene: Hs.524278



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