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  4. GPRC5D (SAR-446523 Biosimilar) Recombinant Monoclonal Antibody

GPRC5D (SAR-446523 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA882153MB2HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    GPRC5D（SAR-446523 Biosimilar Antibody)重組單克隆抗體是一種針對(duì)G蛋白偶聯(lián)受體C5家族D成員（GPRC5D）的生物工程抗體。該抗體通過重組DNA技術(shù)在體外制備，具有高特異性和親和力，能夠精準(zhǔn)識(shí)別并結(jié)合GPRC5D靶點(diǎn)。 作為科研工具，該抗體可用于GPRC5D相關(guān)的基礎(chǔ)研究和機(jī)制探索。GPRC5D在多種生理和病理過程中發(fā)揮作用，其表達(dá)與特定細(xì)胞類型的功能調(diào)控密切相關(guān)。通過使用該重組單克隆抗體，研究人員可深入探究GPRC5D的生物學(xué)特性，包括其在細(xì)胞信號(hào)轉(zhuǎn)導(dǎo)、細(xì)胞增殖與分化等過程中的作用機(jī)制。 該抗體適用于多種實(shí)驗(yàn)技術(shù)，如以，為檢測GPRC5D的表達(dá)水平、亞細(xì)胞定位及相互作用蛋白提供可靠工具。其高度純化的特性確保了實(shí)驗(yàn)結(jié)果的準(zhǔn)確性和可重復(fù)性，有助于推動(dòng)相關(guān)領(lǐng)域的研究進(jìn)展。 作為科研用試劑，該重組單克隆抗體為GPRC5D靶點(diǎn)的功能研究、疾病機(jī)制探討以及潛在治療策略的開發(fā)提供了重要支持。通過特異性靶向GPRC5D，研究人員能夠進(jìn)一步闡明其在疾病發(fā)生發(fā)展中的作用，為后續(xù)的研究工作奠定基礎(chǔ)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    SAR446523 research-grade biosimilar; SAR 446523 research-grade biosimilar ;GPRC5D antibody; G-protein coupled receptor family C group 5 member D antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human GPRC5D protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn)：
    1. GPRC5D in MM cells makes this gene and its encoded surface protein as promising markers for monitoring the tumor load and hopefully also as targets for antimyeloma antibodies. PMID: 23510526
    2. Overexpression of G protein-coupled receptor 5D in the bone marrow is associated with poor prognosis in patients with multiple myeloma. PMID: 22591013
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 3 family
  • 組織特異性：
    Widely expressed in the peripheral system. Expression pattern is high in pancreas, medium in kidney, small intestine, spleen and testis, low in lung, colon, leukocyte, prostate and thymus and not detectable in brain, heart, liver, placenta, skeletal muscl
  • 數(shù)據(jù)庫鏈接：

    HGNC: 13310

    OMIM: 607437

    KEGG: hsa:55507

    STRING: 9606.ENSP00000228887

    UniGene: Hs.644599



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