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  4. GPNMB (Glembatumumab Biosimilar) Recombinant Monoclonal Antibody

GPNMB (Glembatumumab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA622928MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    GPNMB（Glembatumumab Biosimilar Antibody）重組單克隆抗體是一種靶向糖蛋白NMB（GPNMB），其別名包括糖蛋白、跨膜nmb抗體、GPNMB抗體、GPNMB_HUMAN抗體、HGFIN抗體、NMB抗體、骨活化素抗體、跨膜糖蛋白抗體、跨膜糖蛋白HGFIN抗體、跨膜糖蛋白NMB抗體等。該抗體以重組人GPNMB蛋白制備，具有針對(duì)人源GPNMB的特異性結(jié)合能力，種屬反應(yīng)性明確為人類，為其在人體相關(guān)研究中的應(yīng)用提供了特異性保障。 Glembatumumab Biosimilar Antibody作為靶向GPNMB抗體，Glembatumumab的類似物，其作用機(jī)制可能通過(guò)抗體依賴性細(xì)胞介導(dǎo)的細(xì)胞毒性作用（ADCC）或補(bǔ)體依賴的細(xì)胞毒性作用（CDC）特異性殺傷腫瘤細(xì)胞。目前該抗體研發(fā)的藥物的臨床研究主要集中在晚期實(shí)體瘤的治療，尤其在三陰性乳腺癌患者中，早期臨床試驗(yàn)顯示出一定的抗腫瘤活性，可改善患者的無(wú)進(jìn)展生存期，但其長(zhǎng)期療效和安全性仍需大規(guī)模臨床試驗(yàn)進(jìn)一步驗(yàn)證。此外，GPNMB在骨代謝中也發(fā)揮作用，相關(guān)研究探索該抗體研發(fā)的藥物在骨質(zhì)疏松、骨轉(zhuǎn)移等疾病中的治療潛力。 在GPNMB重組單克隆抗體是研究GPNMB生物學(xué)功能的重要工具。研究者可利用該抗體進(jìn)行GPNMB在細(xì)胞中的定位、表達(dá)水平檢測(cè)，如通過(guò)實(shí)驗(yàn)方法，分析其在正常組織與病理狀態(tài)下的表達(dá)差異。在機(jī)制研究中，該抗體可用于探究GPNMB在腫瘤發(fā)生發(fā)展、細(xì)胞增殖、遷移侵襲以及骨重建等信號(hào)通路中的作用，為深入理解相關(guān)疾病的分子機(jī)制提供支持。同時(shí)，通過(guò)構(gòu)建GPNMB過(guò)表達(dá)或敲除細(xì)胞模型，結(jié)合抗體干預(yù)實(shí)驗(yàn)，可進(jìn)一步驗(yàn)證其作為治療靶點(diǎn)的可行性，為開(kāi)發(fā)新的靶向藥物奠定基礎(chǔ)。在多學(xué)科研究中，該抗體也可與其他分子探針或治療藥物聯(lián)合使用，探索聯(lián)合治療策略的協(xié)同效應(yīng)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Glycoprotein；transmembrane nmb antibody; Glycoprotein nmb antibody; Glycoprotein nmb like protein antibody; Gpnmb antibody; GPNMB_HUMAN antibody; HGFIN antibody; NMB antibody; Osteoactivin antibody; Transmembrane glycoprotein antibody; Transmembrane glycoprotein HGFIN antibody; Transmembrane glycoprotein NMB antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human GPNMB protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Could be a melanogenic enzyme.
  • 基因功能參考文獻(xiàn)：
    1. loss of GPNMB, which has been implicated in melanosome formation, autophagy, phagocytosis, tissue repair, and negative regulation of inflammation, underlies autosomal-recessive Amyloidosis cutis dyschromica. PMID: 29336782
    2. Study shows high GPNMB mRNA level in osteosarcoma tissues and cell lines. Its silencing regulates the proliferation and metastasis of osteosarcoma cells by suppressing the PI3K/Akt/mTOR signaling pathway. PMID: 29620278
    3. Serum levels of GPNMB were highly correlated with accumulation of bioactive lipid substrate of Gaucher disease, glucosylsphingosine as well as established biomarkers, chitotriosidase and chemokine, CCL18. PMID: 28003098
    4. Increased brain expression of GPNMB is associated with genome wide significant risk for Parkinson's disease PMID: 28391543
    5. This study revealed that GPNMB aggregates are localized to the neuron, and not localized to the astrocyte and microglia and in the spinal cord of ALS patients. GPNMB has protective effects against mutant TDP-43-induced motor neuron cell death, via ERK1/2 and Akt pathway.. PMID: 27935101
    6. This review will summarize the latest understanding of Gpnmb in the aspects of diagnosis, progression and prognosis of pathological disorders and neoplasms, emphasizing the clinical advances in targeting Gpnmb-expressing malignancies--{REVIEW} PMID: 29441921
    7. The combination of MAPK pathway inhibitors with an antibody-drug conjugate targeting GPNMB is an effective therapeutic option. PMID: 27515299
    8. High GPNMB expression is associated with enhancement of invasive behavior in lung cancer. PMID: 26883195
    9. Findings suggest that MAFK and its target gene GPNMB play important roles in the malignant progression of triple-negative breast cancer (TNBC) cells, offering potentially new therapeutic targets for TNBC patients. PMID: 28400538
    10. glycoprotein non-metastatic B presented increased expression in breast cancer in vivo compared to normal breast tissue PMID: 28689015
    11. Osteoactivin differential regulates the expression of matrix metalloproteases in head and neck squamous cell carcinomas to promote cancer cell invasion. PMID: 28295306
    12. The GPNMB is expressed in a temporal manner during eosinophil development and delivers a proliferative signal upon activation. PMID: 28104809
    13. it may be premature to conclude associations between GPNMB rs156429 and Parkinson's disease, amyotrophic lateral sclerosis and multiple system atrophy. PMID: 27132081
    14. Glycoprotein nonmetastatic melanoma protein B protein was highly expressed in the bladder cancer, which was related to the poor prognosis in bladder cancer patients. Glycoprotein nonmetastatic melanoma protein B promoted the proliferation, migration, and invasion in bladder cancer cells. PMID: 28443476
    15. an inducer for glioma and could enhance matrix metalloproteinase activity through Wnt/beta-catenin pathway to contribute to glioma tumorigenesis PMID: 27334625
    16. findings indicate that GPNMB promotes glioma growth via Na(+)/K(+)-ATPase alpha subunits. Thus, the interaction between GPNMB and Na(+), K(+)-ATPase alpha subunits represents a novel therapeutic target for the treatment of brain glioblastomas. PMID: 27836549
    17. Finally, we identify glycoprotein NMB as a melanocytic marker up-regulated in Tsc2-null mouse uteri and human lymphangioleiomyomatosis samples PMID: 26880751
    18. The GPNMB is a promising biomarker and therapeutic target for the development and progression of Nonalcoholic fatty liver disease in obesity. PMID: 26581806
    19. Osteoactivin in the extracellular matrix promotes oral squamous carcinoma cell adhesion and migration. PMID: 26636434
    20. Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease PMID: 26771826
    21. GPNMB might be a surrogate marker for BC and may cross talk with the HER2 signal pathway. PMID: 26077887
    22. GPNMB plays an important roles in regulating the expression of key pluripotency genes in dental pulp cells and modifying odontogenic differentiation. PMID: 26261527
    23. A positive correlation between GPNMB and NRP-1 levels in human breast tumors. PMID: 25772243
    24. Data shows that the expression of Gpnmb and Spp1 is highly upregulated in glioma-associated microglia/macrophages highlighting the importance of macrophages and microglia as therapeutic targets in anti-tumor treatment regimens. PMID: 25658639
    25. GPNMB/OA protein expression prevents cells from apoptosis-enhancing proliferation and represents a novel modulator of the invasion and metastasis in pancreatic cancer cells. PMID: 25426614
    26. The transcription factor MITF is a critical regulator of GPNMB expression in dendritic cells. PMID: 25889792
    27. GPNMB mRNA in FLCN-related renal cell carcinomas was 23-fold more abundant than in sporadic tumors. PMID: 25594584
    28. GPNMB has protective effect against ischemia-reperfusion injury via phosphorylation of ERK1/2 and Akt PMID: 25010402
    29. Glycoprotein nonmetastatic melanoma protein B plays an important role in angiogenesis during hyperoxia injury PMID: 25054912
    30. DC-HIL+ CD14+ HLA-DR no/low cells are a potential blood marker and therapeutic target for melanoma PMID: 24933321
    31. Our data identify Gpnmb as a novel marker for obesity-induced adipose tissue macrophage infiltration and potentiator of interleukin-4 responses and point toward a crucial role for MITF in driving part of the adipose tissue macrophage phenotype. PMID: 24789918
    32. GPNMB/OA acts as a critical molecular mediator promoting the acquisition of the more aggressive, pro-metastatic phenotype distinctive of human DU145 and PC3 cell lines. PMID: 24589892
    33. our findings will clarify a new explanation about how GPNMB induces bone repair, and provide a potential target for bone regeneration therapeutics and bone engineering PMID: 23794283
    34. the molecular basis for the distinct trafficking and morphogenetic properties of PMEL and GPNMB is the PKD domain PMID: 23452376
    35. GPNMB expression was regulated by EpCAM and CSF-1 partly through their common downstream product c-myc PMID: 23924854
    36. Silencing of GPNMB by siRNA inhibits the formation of melanosomes in melanocytes in a MITF-independent fashion. PMID: 22912767
    37. GPNMB inhibits motor neuron death and plays a critical role in motor neuron survival. PMID: 22891158
    38. Together these results suggest that GPNMB gene is a p53- and androgen-dysregulated gene and should be regarded as an anti-tumor gene for prostate cancer. PMID: 22290289
    39. The abnormal expression of GPNMB may play an important role in the development of prostate cancer. PMID: 21844952
    40. Gastrointestinal stromal tumours do not show immunopositivity for ERa or HMB45. PMID: 22014058
    41. upregulated in monocyte-derived dendritic cells by BCR-ABL tyrosine kinase inhibitors PMID: 21874302
    42. GPNMB increase in kidney disease was confirmed by real-time PCR after 5/6 nephrectomy, in streptozotocin-induced diabetes, and in patients with chronic kidney disease PMID: 21389974
    43. Toxin-conjugated DC-HIL to abrogate the ability of Sezary syndrome cells to proliferate in vitro. PMID: 21252093
    44. ADAM10 as a sheddase capable of releasing the GPNMB/OA ectodomain from the surface of breast cancer cells PMID: 20711474
    45. GPNMB expression has a role in uveal melanoma PMID: 20375921
    46. GPNMB expression is associated with the basal/triple-negative subtype and is a prognostic marker of poor outcome in patients with breast cancer. PMID: 20215530
    47. GPNMB is a melanosomal protein that is released by proteolytic ectodomain shedding and might be a useful and specific histological marker of melanocytic cells. PMID: 20056711
    48. Human OA uses the same transcriptional initiation site in both bone and kidney as was reported for melanoma cells and is expressed in osteoblast cultures at all stages of differentiation PMID: 14696968
    49. cloning and analysis of two fragments in the 5' flanking region of HGFIN; studies indicate p53 cooperates with cytokine-mediated transcription factors to regulate the expression of HGFIN PMID: 15684612
    50. Osteoactivin is expressed at high levels in normal and inflammatory liver macrophages suggesting a significant role in acute liver injury. PMID: 15763343

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  • 相關(guān)疾?。?/div>
    Glioblastoma multiforme patients that exhibit increased mRNA and protein levels (>3-fold over normal brain) in biopsy samples have a significantly higher risk of death (PubMed:16609006). In the context of cancer immunotherapy, including that of melanoma, has been proposed to be used as a cell surface protein antigen targeted by antibodies coupled to cytotoxic drugs (PubMed:16489096).
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Melanosome membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    PMEL/NMB family
  • 組織特異性：
    Widely expressed, but very low expression, if any, in the brain. Expressed in the epidermis with higher levels in melanocytes compared with keratinocytes and Langerhans cells (at protein level). Expressed in peripheral blood, but not bone marrow mononucle
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 4462

    OMIM: 604368

    KEGG: hsa:10457

    STRING: 9606.ENSP00000371420

    UniGene: Hs.190495



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