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  4. GIPR (maridebart Biosimilar) Recombinant Monoclonal Antibody

GIPR (maridebart Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA009438MB2HU
  • 規(guī)格：
    ￥83486
  • 其他：

產品詳情

  • 產品描述：
    GIPR（maridebart Biosimilar Antibody）重組單克隆抗體是一種針對胃抑制多肽受體（Gastric inhibitory polypeptide receptor，簡稱GIPR）。其來源于重組人GIPR蛋白，具有高度的人源種屬反應性，能夠特異性識別并結合人體GIPR，在臨床研究和科研領域具有重要應用價值。 maridebart Biosimilar Antibody作為靶向GIPR抗體，maridebart的類似物，其開發(fā)為代謝性疾病治療提供了新方向。研究表明，GIPR在血糖調控、胰島素敏感性及脂肪代謝中發(fā)揮重要作用，該抗體研發(fā)的藥物通過阻斷或調節(jié)GIPR信號通路，可能為2型糖尿病、肥胖癥等疾病的治療帶來突破。目前，針對maridebart的臨床試驗主要集中于評估其在改善血糖控制、減輕體重及降低心血管風險等方面的療效與安全性，初步結果顯示出良好的治療潛力，為代謝性疾病患者提供了新的治療選擇。 GIPR（maridebart Biosimilar Antibody）重組單克隆抗體憑借其對人源GIPR的特異性結合能力，成為研究GIPR生理功能與病理機制的重要工具?？蒲腥藛T可利用該抗體進行GIPR在組織中的定位分析、受體-配體相互作用研究及信號轉導通路探索實驗。此外，作為其，其與藥物發(fā)現(xiàn)的陽性對照在結構、活性及安全性上高度一致，為相關研究的可重復性和可靠性提供了保障，助力深入揭示GIPR在代謝紊亂、腫瘤發(fā)生等領域的作用機制，推動基礎醫(yī)學研究向臨床轉化。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Gastric inhibitory polypeptide receptor, GIPR
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human GIPR protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產品評價

靶點詳情

  • 功能：
    This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
  • 基因功能參考文獻：
    1. an association between the GIPR rs2302382 polymorphism and type 2 diabetes mellitus in Egyptian patients. PMID: 28744963
    2. Data suggest that GIPR (gastric inhibitory polypeptide receptor) is among the few GPCRs (G-protein-coupled receptors) which signal through G-proteins (GTP-binding protein Gs alpha subunit, here) both at plasma membrane and in endosomes; recombinant proteins expressed in HEK293 cells were used in these studies. PMID: 27641811
    3. GIPR overexpression does not appear to affect acromegalic patients' clinical features PMID: 28179449
    4. Study shows the internalization of GIPR involving clathrin-coated pits, AP-2 and dynamin and its subsequent intracellular trafficking. GIP stimulates a rapid robust internalization of the GIPR, the major part being directed to lysosomes. PMID: 26225752
    5. The common variant rs10423928 in the GIPR gene is associated with increased risk of stroke in patients with type 2 diabetes. PMID: 26395740
    6. Body mass index change for the A/T+A/A in GIPR genotypes was significantly higher than that for the T/T genotype. rs10423928 may predict weight gain in schizophrenia. PMID: 25321336
    7. The potential future role of gastric inhibitory peptide (GIP) receptors as molecular targets in neuroendocrine neoplasms may be dependent on the tumor grade. PMID: 25591947
    8. Results show that GIPR undergoes trafficking between the plasma membrane and intracellular compartments of both GIP-stimulated and unstimulated adipocytes. PMID: 25047836
    9. GIPR is overexpressed in gastric and duodenal neuroendocrine tumors PMID: 24565507
    10. GIPR expression was downregulated in subcutaneous adipose tissue from obese patients and correlated negatively with body mass index, waist circumference, systolic blood pressure, and glucose and triglyceride levels. PMID: 24512489
    11. GIPR promoter was hypomethylated in type 2 diabetic patients as compared to controls. PMID: 24086540
    12. This study demonstrates an association between a functional GIPR polymorphism Glu354Gln (rs1800437) and Bone mineral density and fracture risk. PMID: 24446656
    13. Compared with the current treatment standard SSTR2, GIPR has only somewhat lesser absolute gene expression in tumor tissue but much lesser expression in normal tissue, making it a promising new target for neuroendocrine tumor imaging and therapy. PMID: 24238043
    14. Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor. PMID: 23689510
    15. Functional expression of a GIP receptor mutant lacking N-glycosylation is rescued by co-expressed wild type GLP1 receptor, which suggests formation of a GIP-GLP1 receptor heteromer. PMID: 22412906
    16. Our prospective, observational study indicates that the type 2 diabetes risk by dietary intake of carbohydrate and fat may be dependent on GIPR genotype. PMID: 22399504
    17. Most of the somatostatin receptor-negative neuroendocrine tumors and GLP-1 receptor-negative malignant insulinomas are GIP receptor positive. PMID: 22112810
    18. The T allele of GIPR rs2287019 is associated with greater improvement of glucose homeostasis in individuals who choose a low-fat, high-carbohydrate, and high-fiber diet. PMID: 22237064
    19. a role of the adipocyte GIPr in nutrient-dependent regulation of body weight and lean mass, but it does not support a direct and independent role for the adipocyte or beta-cell GIPr in promoting adipogenesis. PMID: 22027838
    20. Variations of the GIPR sequence are not associated with childhood obesity. PMID: 20516203
    21. Variants at the GIPR locus associated with 2-h glucose level (rs10423928, beta (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 x 10(-15)), were identified. PMID: 20081857
    22. Proximal 5' flanking region is TATA-less and contains a GC-rich region involved in cellular expression. PMID: 12530665
    23. differences in cellular response to gastric inhibitory polypeptide(GIP) mediated by endothelin-1 may be related to differences in activation of GIP receptor splice variants PMID: 12721154
    24. Glucose-stimulated insulin secretion is maintained despite complete absence of both GIP-1 and GIP receptors. Role for incretin receptors as essential downstream targets for glucoregulatory actions of DPP-IV inhibitors. PMID: 15111503
    25. Proximal promoter of GIP-R gene contains a GC-rich region capable of binding to Sp1 and SP3. PMID: 15666829
    26. the promoter region of the GIP-R gene revealed six consensus sequences important in regulating the reporter gene activity and capable of binding to Sp1 and Sp3 transcription factors PMID: 16087722
    27. GIPR adipose tissue gene expression was significantly lower in insulin resistant obese non-diabetic women PMID: 17395281
    28. GIPR overexpression was observed in pediatric and adult adrenocortical tumors PMID: 18971217
    29. Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis. PMID: 19211686
    30. Our data suggest a potential relevance of GIPR variants for obesity. PMID: 19254363
    31. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GLP-1R and GIP-R. PMID: 19386626

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family
  • 數(shù)據庫鏈接：

    HGNC: 4271

    OMIM: 137241

    KEGG: hsa:2696

    STRING: 9606.ENSP00000467494

    UniGene: Hs.251412



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