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  4. GIPR (CN 112521501 A Biosimilar) Recombinant Monoclonal Antibody

GIPR (CN 112521501 A Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA009438MB3HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    GIPR (CN 112521501 A Biosimilar Antibody) 重組單克隆抗體是一種針對胃抑制性多肽受體（Gastric inhibitory polypeptide receptor, GIPR）重組單克隆抗體。GIPR作為其核心靶點，屬于G蛋白偶聯(lián)受體家族，在糖代謝調(diào)節(jié)、能量平衡及肥胖發(fā)生機(jī)制中發(fā)揮關(guān)鍵作用。該抗體以重組人GIPR蛋白制備，具有高度的靶向特異性，可特異性識別并結(jié)合GIPR，從而調(diào)控下游信號通路活性。 GIPR靶向藥物因其在代謝性疾病中的潛在價值備受關(guān)注。目前研究表明，GIPR參與葡萄糖依賴性促胰島素分泌及脂肪細(xì)胞分化過程，相關(guān)藥物可能通過抑制GIPR活性改善胰島素抵抗、降低體重，為2型糖尿病和肥胖癥的治療提供新策略。臨床前研究顯示，該抗體研發(fā)的藥物在食蟹猴（Macaca fascicularis）模型中表現(xiàn)出良好的種屬交叉反應(yīng)性，為非臨床藥效及安全性評價提供了重要實驗依據(jù)，目前正逐步推進(jìn)臨床試驗以驗證其臨床療效與安全性。 該抗體憑借對人和食蟹猴GIPR的特異性識別能力，成為代謝疾病機(jī)制研究的重要工具。研究者可利用其開展GIPR在組織分布、信號轉(zhuǎn)導(dǎo)及疾病關(guān)聯(lián)等方面的基礎(chǔ)研究，例如通過技術(shù)分析GIPR在脂肪組織、胰島β細(xì)胞中的表達(dá)模式，或結(jié)合動物模型探究其在能量代謝調(diào)控中的分子機(jī)制。此外，作為其候選藥物，其開發(fā)過程也為其的質(zhì)量控制、活性測定等藥學(xué)研究提供了參考范例，推動相關(guān)領(lǐng)域的技術(shù)創(chuàng)新與標(biāo)準(zhǔn)化發(fā)展。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Gastric inhibitory polypeptide receptor, GIPR
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human GIPR protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
  • 基因功能參考文獻(xiàn)：
    1. an association between the GIPR rs2302382 polymorphism and type 2 diabetes mellitus in Egyptian patients. PMID: 28744963
    2. Data suggest that GIPR (gastric inhibitory polypeptide receptor) is among the few GPCRs (G-protein-coupled receptors) which signal through G-proteins (GTP-binding protein Gs alpha subunit, here) both at plasma membrane and in endosomes; recombinant proteins expressed in HEK293 cells were used in these studies. PMID: 27641811
    3. GIPR overexpression does not appear to affect acromegalic patients' clinical features PMID: 28179449
    4. Study shows the internalization of GIPR involving clathrin-coated pits, AP-2 and dynamin and its subsequent intracellular trafficking. GIP stimulates a rapid robust internalization of the GIPR, the major part being directed to lysosomes. PMID: 26225752
    5. The common variant rs10423928 in the GIPR gene is associated with increased risk of stroke in patients with type 2 diabetes. PMID: 26395740
    6. Body mass index change for the A/T+A/A in GIPR genotypes was significantly higher than that for the T/T genotype. rs10423928 may predict weight gain in schizophrenia. PMID: 25321336
    7. The potential future role of gastric inhibitory peptide (GIP) receptors as molecular targets in neuroendocrine neoplasms may be dependent on the tumor grade. PMID: 25591947
    8. Results show that GIPR undergoes trafficking between the plasma membrane and intracellular compartments of both GIP-stimulated and unstimulated adipocytes. PMID: 25047836
    9. GIPR is overexpressed in gastric and duodenal neuroendocrine tumors PMID: 24565507
    10. GIPR expression was downregulated in subcutaneous adipose tissue from obese patients and correlated negatively with body mass index, waist circumference, systolic blood pressure, and glucose and triglyceride levels. PMID: 24512489
    11. GIPR promoter was hypomethylated in type 2 diabetic patients as compared to controls. PMID: 24086540
    12. This study demonstrates an association between a functional GIPR polymorphism Glu354Gln (rs1800437) and Bone mineral density and fracture risk. PMID: 24446656
    13. Compared with the current treatment standard SSTR2, GIPR has only somewhat lesser absolute gene expression in tumor tissue but much lesser expression in normal tissue, making it a promising new target for neuroendocrine tumor imaging and therapy. PMID: 24238043
    14. Structural and pharmacological characterization of novel potent and selective monoclonal antibody antagonists of glucose-dependent insulinotropic polypeptide receptor. PMID: 23689510
    15. Functional expression of a GIP receptor mutant lacking N-glycosylation is rescued by co-expressed wild type GLP1 receptor, which suggests formation of a GIP-GLP1 receptor heteromer. PMID: 22412906
    16. Our prospective, observational study indicates that the type 2 diabetes risk by dietary intake of carbohydrate and fat may be dependent on GIPR genotype. PMID: 22399504
    17. Most of the somatostatin receptor-negative neuroendocrine tumors and GLP-1 receptor-negative malignant insulinomas are GIP receptor positive. PMID: 22112810
    18. The T allele of GIPR rs2287019 is associated with greater improvement of glucose homeostasis in individuals who choose a low-fat, high-carbohydrate, and high-fiber diet. PMID: 22237064
    19. a role of the adipocyte GIPr in nutrient-dependent regulation of body weight and lean mass, but it does not support a direct and independent role for the adipocyte or beta-cell GIPr in promoting adipogenesis. PMID: 22027838
    20. Variations of the GIPR sequence are not associated with childhood obesity. PMID: 20516203
    21. Variants at the GIPR locus associated with 2-h glucose level (rs10423928, beta (s.e.m.) = 0.09 (0.01) mmol/l per A allele, P = 2.0 x 10(-15)), were identified. PMID: 20081857
    22. Proximal 5' flanking region is TATA-less and contains a GC-rich region involved in cellular expression. PMID: 12530665
    23. differences in cellular response to gastric inhibitory polypeptide(GIP) mediated by endothelin-1 may be related to differences in activation of GIP receptor splice variants PMID: 12721154
    24. Glucose-stimulated insulin secretion is maintained despite complete absence of both GIP-1 and GIP receptors. Role for incretin receptors as essential downstream targets for glucoregulatory actions of DPP-IV inhibitors. PMID: 15111503
    25. Proximal promoter of GIP-R gene contains a GC-rich region capable of binding to Sp1 and SP3. PMID: 15666829
    26. the promoter region of the GIP-R gene revealed six consensus sequences important in regulating the reporter gene activity and capable of binding to Sp1 and Sp3 transcription factors PMID: 16087722
    27. GIPR adipose tissue gene expression was significantly lower in insulin resistant obese non-diabetic women PMID: 17395281
    28. GIPR overexpression was observed in pediatric and adult adrenocortical tumors PMID: 18971217
    29. Diabetic kidney lesions of GIPRdn transgenic mice: podocyte hypertrophy and thickening of the GBM precede glomerular hypertrophy and glomerulosclerosis. PMID: 19211686
    30. Our data suggest a potential relevance of GIPR variants for obesity. PMID: 19254363
    31. Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GLP-1R and GIP-R. PMID: 19386626

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  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4271

    OMIM: 137241

    KEGG: hsa:2696

    STRING: 9606.ENSP00000467494

    UniGene: Hs.251412



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