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  4. GFRAL (NGM-120 Biosimilar) Recombinant Monoclonal Antibody

GFRAL (NGM-120 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA751020MB2HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    GFRAL (NGM-120 Biosimilar Antibody)重組單克隆抗體是一種針對(duì)生長分化因子15（GDF15）受體GFRAL的靶向生物制劑，主要用于科研領(lǐng)域的機(jī)制研究與實(shí)驗(yàn)?zāi)Ｐ蜆?gòu)建。該抗體通過基因工程技術(shù)重組表達(dá)，具有高特異性和親和力，能夠精準(zhǔn)識(shí)別并結(jié)合GFRAL受體，進(jìn)而調(diào)控其下游信號(hào)通路。 在學(xué)術(shù)研究中，GFRAL (NGM-120 Biosimilar Antibody)重組單克隆抗體可作為工具試劑，助力探索GDF15-GFRAL信號(hào)軸在能量代謝、體重調(diào)節(jié)、腫瘤微環(huán)境以及神經(jīng)退行性疾病等領(lǐng)域的作用機(jī)制。通過特異性阻斷或激活GFRAL受體，研究人員能夠深入分析該通路對(duì)生理及病理過程的影響，為相關(guān)疾病的發(fā)病機(jī)制研究提供關(guān)鍵實(shí)驗(yàn)數(shù)據(jù)。 該抗體具備良好的生物活性和批次穩(wěn)定性，適用于細(xì)胞水平的體外實(shí)驗(yàn)（如受體結(jié)合實(shí)驗(yàn)、信號(hào)通路分析）及動(dòng)物模型的體內(nèi)研究（如藥效學(xué)評(píng)估、組織分布觀察）。其重組表達(dá)工藝確保了產(chǎn)品的高純度和低批次間差異，為科研結(jié)果的可靠性與可重復(fù)性提供有力支持。 作為科研用工具試劑，GFRAL (NGM-120 Biosimilar Antibody)重組單克隆抗體為生命科學(xué)領(lǐng)域的基礎(chǔ)研究與轉(zhuǎn)化醫(yī)學(xué)探索提供了重要支持，有助于推動(dòng)對(duì)GFRAL相關(guān)疾病機(jī)制的深入理解，并為潛在治療靶點(diǎn)的發(fā)現(xiàn)提供實(shí)驗(yàn)依據(jù)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    NGM 120 research-grade biosimilar ;GFRAL antibody; C6orf144 antibody; UNQ9356/PRO34128 antibody; GDNF family receptor alpha-like antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human GFRAL protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass membrane protein; Extracellular side.
  • 蛋白家族：
    GDNFR family
  • 組織特異性：
    Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius (at protein level). Detected at low levels in testis and adipose tissue.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 32789

    OMIM: 617837

    KEGG: hsa:389400

    STRING: 9606.ENSP00000343636

    UniGene: Hs.526967



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