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  4. FZD10 (OTSA-101-DTPA-90Y Biosimilar) Recombinant Monoclonal Antibody

FZD10 (OTSA-101-DTPA-90Y Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA891782MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    FZD10（OTSA-101-DTPA-90Y Biosimilar Antibody)重組單克隆抗體是一種針對(duì)FZD10靶點(diǎn)的研究用生物制劑。該抗體通過重組DNA技術(shù)制備，具有高特異性和親和力，能夠精準(zhǔn)識(shí)別并結(jié)合FZD10蛋白。FZD10作為Wnt信號(hào)通路的重要成員，在多種腫瘤中異常表達(dá)，是腫瘤發(fā)生發(fā)展的關(guān)鍵調(diào)控因子之一，因此成為癌癥研究領(lǐng)域的重要靶點(diǎn)。 該抗體的研發(fā)為探索FZD10在腫瘤微環(huán)境中的功能提供了有力工具。研究人員可利用其特異性結(jié)合特性，開展FZD10蛋白的表達(dá)定位、信號(hào)通路機(jī)制及腫瘤細(xì)胞生物學(xué)行為的研究。此外，該抗體偶聯(lián)了DTPA-90Y放射性標(biāo)記，可用于腫瘤靶向成像和放射免疫治療的相關(guān)研究，為開發(fā)新型腫瘤診斷與治療策略提供實(shí)驗(yàn)基礎(chǔ)。 在科研應(yīng)用中，F(xiàn)ZD10重組單克隆抗體可助力揭示W(wǎng)nt/FZD10信號(hào)軸在腫瘤發(fā)生、侵襲和轉(zhuǎn)移中的作用機(jī)制，為癌癥的精準(zhǔn)治療研究提供理論依據(jù)。其高度的靶向性和生物活性，使其成為腫瘤生物學(xué)、分子醫(yī)學(xué)等領(lǐng)域基礎(chǔ)研究和轉(zhuǎn)化醫(yī)學(xué)研究的重要試劑。通過該抗體的應(yīng)用，有望推動(dòng)對(duì)FZD10相關(guān)疾病機(jī)制的深入理解，為后續(xù)的藥物研發(fā)和臨床前研究奠定基礎(chǔ)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    OTSA-101-DTPA-90Y research-grade biosimilar ;FZD10 antibody; Frizzled-10 antibody; Fz-10 antibody; hFz10 antibody; FzE7 antibody; CD antigen CD350 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human FZD10 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable).
  • 基因功能參考文獻(xiàn)：
    1. there was a strong inverse correlation between nuclear immunostaining scores for beta-catenin expression and expression patterns of FZD10 PMID: 19134005
    2. FZD10 transactivation causes the activation of the Dvl-Rac1-JNK pathway and is associated with the development/progression of synovial sarcomas PMID: 19137009
  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor Fz/Smo family
  • 組織特異性：
    Highest levels in the placenta and fetal kidney, followed by fetal lung and brain. In adult brain, abundantly expressed in the cerebellum, followed by cerebral cortex, medulla and spinal cord; very low levels in total brain, frontal lobe, temporal lobe an
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4039

    OMIM: 606147

    KEGG: hsa:11211

    STRING: 9606.ENSP00000229030

    UniGene: Hs.31664



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