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  4. ENPP3 (US2020317814 Biosimilar) Recombinant Monoclonal Antibody

ENPP3 (US2020317814 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號(hào)：
    CSB-RA007681MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    ENPP3 (US2020317814 Biosimilar Antibody) 重組單克隆抗體是一種針對(duì)人ENPP3蛋白，其別名為堿性磷酸二酯酶I抗體、CD203c抗體、NPP3抗體等，涵蓋了該分子在不同研究領(lǐng)域的多種命名。該抗體以重組人ENPP3蛋白制備，能特異性結(jié)合ENPP3分子，適用于人及食蟹猴樣本的實(shí)驗(yàn)研究。 ENPP3作為一種細(xì)胞表面酶，屬于核苷酸焦磷酸酶/磷酸二酯酶家族成員，在調(diào)節(jié)細(xì)胞外核苷酸代謝、信號(hào)轉(zhuǎn)導(dǎo)及免疫反應(yīng)中發(fā)揮關(guān)鍵作用?；贓NPP3開(kāi)發(fā)的靶向藥物在臨床研究中顯示出應(yīng)用潛力，尤其在胰腺癌、肝癌等惡性腫瘤治療領(lǐng)域，相關(guān)藥物旨在通過(guò)抑制ENPP3活性阻斷腫瘤血管生成，目前正處于臨床試驗(yàn)階段；此外，檢測(cè)患者血清或腫瘤組織中ENPP3的表達(dá)水平，可輔助評(píng)估腫瘤分期及預(yù)后，為臨床診療提供參考。 該抗體廣泛應(yīng)用于分子生物學(xué)和細(xì)胞生物學(xué)研究。借助技術(shù)，可實(shí)現(xiàn)對(duì)ENPP3蛋白的定性與定量分析，助力揭示其在生理病理過(guò)程中的作用機(jī)制。例如，在免疫細(xì)胞研究中，CD203c（ENPP3）作為嗜堿性粒細(xì)胞和肥大細(xì)胞的活化標(biāo)志物，該抗體可用于監(jiān)測(cè)過(guò)敏反應(yīng)或免疫相關(guān)疾病中免疫細(xì)胞的激活狀態(tài)。此外，針對(duì)食蟹猴的種屬反應(yīng)性使其適用于非臨床藥效及安全性評(píng)價(jià)，為臨床前研究提供可靠工具。 綜上，ENPP3重組單克隆抗體不僅為基礎(chǔ)研究提供了特異性檢測(cè)工具，也為腫瘤等疾病的臨床診斷與靶向治療開(kāi)發(fā)奠定了重要基礎(chǔ)，具有顯著的科研價(jià)值和臨床轉(zhuǎn)化潛力。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Alkaline phosphodiesterase I antibody; ARHR2 antibody; B10 antibody; CD203c antibody; CD203c antigen antibody; dJ1005H11.3；phosphodiesterase I/nucleotide pyrophosphatase 3 antibody; dJ914N13.3；phosphodiesterase I/nucleotide pyrophosphatase 3 antibody; E NPP 3 antibody; E-NPP 3 antibody; Ectonucleotide pyrophosphatase/phosphodiesterase 3 antibody; Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 antibody; ENPP3 antibody; ENPP3_HUMAN antibody; gp130RB13 6 antibody; gp130RB136 antibody; M6S1 antibody; NPP1 antibody; NPP3 antibody; NPPase antibody; NPPS antibody; Nucleotide pyrophosphatase antibody; PC 1 antibody; PC-1 antibody; PCA1 antibody; PD Ibeta antibody; PD-Ibeta antibody; PDNP1 antibody; PDNP3 antibody; Phosphodiesterase I beta antibody; Phosphodiesterase I/nucleotide pyrophosphatase 3 antibody; phosphodiesterase i/nucleotide pyrophosphatase beta antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human ENPP3 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說(shuō)明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP. Limits mast cell and basophil responses during inflammation and during the chronic phases of allergic responses by eliminating the extracellular ATP that functions as signaling molecule and activates basophils and mast cells and induces the release of inflammatory cytokines. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells. Has also alkaline phosphodiesterase activity.
  • 基因功能參考文獻(xiàn)：
    1. We showed the ability of the immunological marker CD203c to predict the clinical efficacy of sublingual immunotherapy on rhinitis subjects allergic to Parietaria. PMID: 29702283
    2. Basophil CD203c surface expression reliably discriminated cystic fibrosis with allergic bronchopulmonary aspergillosis from cystic fibrosis with Aspergillus colonization and cystic fibrosis over time. PMID: 26585435
    3. Expression of CD203c on basophils as a marker of immunoglobulin E-mediated (L)-asparaginase allergy. PMID: 23581640
    4. Anaphylactic transfusion reaction in homozygous haptoglobin deficiency detected by CD203c expression on basophils. PMID: 24497482
    5. ENPP3 is a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb) PMID: 23960081
    6. The early signaling requirements for the CD11b/CD203c compartment expression and CD63 degranulation provide support for the hypothesis that CD11b and CD203c reside in a similar compartment. PMID: 22722613
    7. Subjects with nut allergy show an increase of basophil CD203c levels at baseline and following rapid ex vivo stimulation with nut allergen PMID: 20975283
    8. Asthma exacerbation was accompanied by increased expression of CD203c on basophils that decreased significantly during remission PMID: 20159259
    9. Influence of hyperosmotic conditions on basophil CD203c upregulation in patients with food-dependent exercise-induced anaphylaxis. PMID: 20047266
    10. Data show that low and high dilutions of histamine inhibit CD203c up-regulation in anti-IgE stimulated basophils. PMID: 19418203
    11. E-NPP3 is associated with carcinogenesis of human colon cancer and that serum E-NPP3 might be a tumor marker of colon carcinoma PMID: 14533006
    12. E-NPP3 is involved in the infiltration of neoplastic bile duct carcinoma PMID: 15072822
    13. Our data demonstrate that leptin promotes platelet activation, provides a mechanistic basis for the prothrombotic effect of this hormone, and identifies a potentially novel therapeutic avenue to limit obesity-associated cardiovascular disease. PMID: 15886225
    14. In conclusion, using well-defined experimental conditions, the measurement of CD203c up-regulation on basophils in response to specific allergens is as reliable as CD63-BAT for the in vitro diagnosis of patients with IgE-mediated allergy. PMID: 17275019

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  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type II membrane protein. Apical cell membrane; Single-pass type II membrane protein. Secreted.
  • 蛋白家族：
    Nucleotide pyrophosphatase/phosphodiesterase family
  • 組織特異性：
    Detected on bile ducts in liver, and in blood serum (at protein level). Detected in prostate and uterus. Detected on basophils, but not neutrophils.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 3358

    OMIM: 602182

    KEGG: hsa:5169

    STRING: 9606.ENSP00000350265

    UniGene: Hs.486489



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