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  4. DPP3 (Procizumab Biosimilar) Recombinant Monoclonal Antibody

DPP3 (Procizumab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA868352MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    DPP3 (Procizumab Biosimilar) Recombinant Monoclonal Antibody是一種用于科研領(lǐng)域的重組單克隆抗體。該抗體通過基因工程技術(shù)制備，具有高度的特異性和親和力，能夠精準識別并結(jié)合目標分子，為相關(guān)研究提供可靠的工具。 在科研應(yīng)用中，該重組單克隆抗體可用于多種實驗場景。例如，在蛋白質(zhì)相互作用研究中，它能幫助科研人員探究目標蛋白的功能及調(diào)控機制；在細胞生物學研究里，可借助其特異性結(jié)合特性，對細胞內(nèi)相關(guān)通路的活動進行檢測與分析。 其作為重組抗體，具有批間一致性好、純度高等優(yōu)點，能夠減少實驗過程中的干擾因素，提高實驗結(jié)果的可靠性和重復(fù)性?？蒲腥藛T可利用該抗體開展一系列基礎(chǔ)研究工作，為深入了解相關(guān)生物學過程和疾病機制提供有力支持。 無論是在分子水平的機制研究，還是在細胞層面的功能探索，DPP3 (Procizumab Biosimilar) Recombinant Monoclonal Antibody都展現(xiàn)出重要的科研價值，是生命科學研究領(lǐng)域中一種實用的科研試劑。
  • Uniprot No.：
  • 基因名：
  • 別名：
    AK-1967 research-grade biosimilar; PCZ research-grade biosimilar ;DPP3 antibody; Dipeptidyl peptidase 3 antibody; EC 3.4.14.4 antibody; Dipeptidyl aminopeptidase III antibody; Dipeptidyl arylamidase III antibody; Dipeptidyl peptidase III antibody; DPP III antibody; Enkephalinase B antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human DPP3 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    3-4 weeks
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    Cleaves and degrades bioactive peptides, including angiotensin, Leu-enkephalin and Met-enkephalin. Also cleaves Arg-Arg-beta-naphthylamide (in vitro).
  • 基因功能參考文獻：
    1. We conclude that DPP 3 may influence the cellular expression of Ang-(1-7) and potentially reflect a therapeutic target to augment the actions of the peptide PMID: 27315786
    2. biological function of human dipeptidyl peptidase III PMID: 26887037
    3. several crystal structures of complexes of human dipeptidyl peptidase III with different peptides. PMID: 27025154
    4. Evidence for concurrent expression of hDPP III mRNA V-I and V-II in multiple human tumor derived cell lines. PMID: 27153830
    5. the DPP III conformational landscape and the influence of ligand binding on the protein structure and dynamics, was investigated. PMID: 26334575
    6. Kinetic studies revealed that the single mutant D496G lost selectivity due to the increase of the Km value. The D496G, but not S504G, showed significantly decreased binding of peptides with N-terminal arginine, and of tynorphin. PMID: 25581752
    7. The study used three different conformations of human dipeptidyl-peptidase III (DPP III) to investigate the influence of the protein environment on ligand binding and the Zn(2+) coordination. PMID: 25192149
    8. Deletion/mutagenesis of C/EBP-beta binding motif of DPP III promoter significantly increased its activity and abolished its responsiveness to IL-6 in glioblastoma cells. PMID: 24472318
    9. The activity of the yeast and human dipeptidyl peptidase III were examined. PMID: 23362197
    10. Combined results of mutational analysis and mass spectrometry suggest that glutathionylation (formation of mixed disulfide) of Cys176 and Cys654 contributes to human DPP III inactivation by oxidized glutathione. PMID: 23667907
    11. Amplification and mRNA overexpression of the DPP3 gene is associated with squamous cell lung carcinomas. PMID: 23382044
    12. results provide the basis for the design of specific inhibitors that enable the elucidation of the exact role of DPP III and the exploration of its potential as a target of pain intervention strategies PMID: 22493238
    13. Ets-1/Elk-1 is a critical mediator of DPP3 transcription in human glioblastoma cells. PMID: 20236318
    14. In malignant neoplasms of the ovary DPP III activity increased with growing histologic grade. PMID: 14529681
    15. the conserved tyrosine could be involved in transition state stabilization during the catalytic action of M49 peptidases. PMID: 18163885

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  • 亞細胞定位：
    Cytoplasm, cytosol.
  • 蛋白家族：
    Peptidase M49 family
  • 組織特異性：
    Detected in placenta (at protein level). Detected in erythrocytes (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 3008

    OMIM: 606818

    KEGG: hsa:10072

    STRING: 9606.ENSP00000353701

    UniGene: Hs.502914



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