DPEP3 (US10189910B2 Biosimilar Antibody) 重組單克隆抗體是一種針對人二肽酶3（Dipeptidase 3, DPEP3）重組單克隆抗體，其別名為Dipeptidase 3 antibody、DPEP3 antibody或UNQ834/PRO1772 antibody。該抗體以重組人DPEP3蛋白制備而成，具有高度特異性和親和力，可特異性識別人及食蟹猴（Macaca fascicularis）的DPEP3蛋白，為跨物種研究提供了可靠工具。 DPEP3可基于其參與肽類代謝的膜結(jié)合酶特性，開發(fā)用于相關(guān)疾病的治療。DPEP3的異常表達(dá)與多種疾病的發(fā)生發(fā)展密切相關(guān)，如腫瘤微環(huán)境調(diào)控、炎癥反應(yīng)及腎臟疾病等，針對這些疾病開發(fā)類似物有望通過調(diào)控DPEP3活性發(fā)揮治療作用。此類藥物與現(xiàn)有治療手段相比，可能具有相似的結(jié)構(gòu)和生物活性，有助于降低治療成本，為患者提供更多治療選擇。目前，針對DPEP3在腫瘤侵襲轉(zhuǎn)移中的作用及靶向藥物的臨床前研究正在逐步開展，旨在探索其在實(shí)體瘤治療中的應(yīng)用前景。 該抗體可廣泛應(yīng)用于實(shí)驗，助力研究者在分子和細(xì)胞水平解析DPEP3的表達(dá)模式、亞細(xì)胞定位及相互作用蛋白。鑒于其對人和食蟹猴的種屬反應(yīng)性，該抗體適用于臨床前動物模型與人體樣本的對比研究，為從基礎(chǔ)研究到臨床轉(zhuǎn)化提供重要支持。此外，通過特異性阻斷DPEP3活性，該抗體可用于探究其在生理病理過程中的功能，為揭示相關(guān)疾病的分子機(jī)制提供關(guān)鍵實(shí)驗工具。

Q9H4B8

Dipeptidase 3 antibody; DPEP3 antibody; UNQ834/PRO1772 antibody

Human

Recombinant Human DPEP3 protein

Homo sapiens (Human)

Non-conjugated

Monoclonal

It differs from different batches. Please contact us to confirm it.

0.01M PBS，pH7.4

Liquid

Validation Status
Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
Guaranteed Quality
① Antibody purity?> 95% tested by SDS-PAGE.
② Endotoxin level < 0.1EU/ug tested by LAL method.

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

In stock

It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.