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  4. DLL3 (Rovalpituzumab Biosimilar) Recombinant Monoclonal Antibody

DLL3 (Rovalpituzumab Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA882142MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    DLL3 (Rovalpituzumab Biosimilar Antibody) 重組單克隆抗體是一種靶向Delta樣蛋白3（DLL3），DLL3又名Delta-like protein 3、Drosophila Delta homolog 3或Delta3，是Notch信號通路中的關(guān)鍵跨膜蛋白。該抗體以重組人DLL3蛋白制備，具有高度的人源種屬反應(yīng)性，可特異性識別并結(jié)合人DLL3分子，在腫瘤治療和科研領(lǐng)域具有重要應(yīng)用價值。 靶向DLL3的抗體偶聯(lián)藥物（ADC）Rovalpituzumab tesirine（Rova-T）通過將細(xì)胞毒性藥物遞送至高表達(dá)DLL3的腫瘤細(xì)胞（如小細(xì)胞肺癌（SCLC）、神經(jīng)內(nèi)分泌腫瘤等）發(fā)揮作用，DLL3在這些惡性腫瘤中高表達(dá)而在正常組織中表達(dá)有限的特性使其成為理想靶點(diǎn)，Rova-T已在多項(xiàng)臨床試驗(yàn)中展現(xiàn)出抗腫瘤活性。作為Rova-T藥物發(fā)現(xiàn)的陽性對照，DLL3重組單克隆抗體在保持相似靶向性的同時，有望降低治療成本，為患者提供更多治療選擇。目前，相關(guān)臨床研究主要聚焦于評估其在復(fù)發(fā)/難治性SCLC及其他神經(jīng)內(nèi)分泌腫瘤中的安全性和有效性，探索聯(lián)合免疫治療或化療的協(xié)同效應(yīng)。 該抗體可作為特異性檢測工具，用于實(shí)驗(yàn)，助力DLL3蛋白的表達(dá)定位、功能機(jī)制及信號通路研究。通過結(jié)合DLL3，研究者能深入探究其在腫瘤發(fā)生發(fā)展、細(xì)胞分化及轉(zhuǎn)移中的作用，為開發(fā)新型靶向藥物提供實(shí)驗(yàn)基礎(chǔ)。此外，利用其種屬反應(yīng)性特點(diǎn)，可構(gòu)建人源化腫瘤模型，驗(yàn)證DLL3靶向療法的體內(nèi)效果，推動轉(zhuǎn)化醫(yī)學(xué)研究進(jìn)展。 DLL3是生物學(xué)功能的重要科研工具，為腫瘤精準(zhǔn)治療和基礎(chǔ)研究提供雙重支持。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Delta-like protein 3；Drosophila Delta homolog 3；Delta3, DLL3
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human DLL3 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm.
  • 基因功能參考文獻(xiàn)：
    1. these results reveal that DLL3 is expressed in tumor specimens from most patients with small cell lung cancer PMID: 29290251
    2. Results indicated that DLL3 expression was silenced in hepatocellular carcinoma (HCC) cells by DNA methylation and was more readily affected by histone acetylation than histone methylation (H3K9me2 or H3K27me3). PMID: 29512761
    3. our results indicated epidermal growth factor-like domain multiple 7 protein participates in growth hormone-secreting pituitary adenoma proliferation and invasion regulation via Notch2/DLL3 signaling pathway. These findings raised the possibility that epidermal growth factor-like domain multiple 7 protein might serve as a useful biomarker to assess growth hormone-secreting pituitary adenoma invasion and prognosis PMID: 28705113
    4. The Dll3 was rarely detectable in the para-carcinoma tissues, but positive in 82.1% of non-small cell cancer tissues. PMID: 28007595
    5. Both global haplotype and individual haplotype analyses showed that the haplotypes of SNP1/SNP2/SNP3/SNP4/SNP5 did not correlate with the disease (P >0.05). Together, these data suggest that genetic variants of the DLL3 gene are not associated with CS in the Chinese Han population. PMID: 27472720
    6. DLL3 was silenced by methylation in human human hepatocellular carcinoma and it negatively regulates the growth of human hepatocellular carcinoma cells. PMID: 23337976
    7. We suggest that the three human DLL3 mutations associated with spondylocostal dysplasia are also functionally equivalent to the Dll3(neo) null allele in mice. PMID: 11923214
    8. mutations in DLL3 cause a consistent pattern of abnormal vertebral segmentation in spondylocostal dysostosis PMID: 12746394
    9. no novel or previously described mutations are present in our cohort, indicating that DLL3 mutations may not be a major cause of congenital scoliosis. PMID: 15717203
    10. The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity PMID: 18676613

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  • 相關(guān)疾?。?/div>
    Spondylocostal dysostosis 1, autosomal recessive (SCDO1)
  • 亞細(xì)胞定位：
    Membrane; Single-pass type I membrane protein.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2909

    OMIM: 277300

    KEGG: hsa:10683

    STRING: 9606.ENSP00000205143

    UniGene: Hs.127792



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