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  4. DDR1 (US20140199312 Biosimilar) Recombinant Monoclonal Antibody

DDR1 (US20140199312 Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA006595MB1HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    DDR1 (US20140199312 Biosimilar Antibody) 重組單克隆抗體是一種針對盤狀結(jié)構(gòu)域受體1（DDR1），其源自重組人DDR1蛋白，種屬反應(yīng)性為人類。DDR1作為受體酪氨酸激酶家族成員，在多種生理與病理過程中發(fā)揮關(guān)鍵作用，其別名包括CD167抗體、CAK抗體、PTK3抗體等，反映了其在細(xì)胞黏附、信號轉(zhuǎn)導(dǎo)及腫瘤發(fā)生中的多重功能關(guān)聯(lián)。 在DDR1靶向藥物的基于DDR1在乳腺癌、非小細(xì)胞肺癌、肝癌等多種惡性腫瘤中高表達(dá)的特性，相關(guān)藥物通過調(diào)控細(xì)胞增殖、侵襲及血管生成參與腫瘤進(jìn)展的干預(yù)。此類藥物可特異性作用于DDR1，阻斷其與配體（如膠原蛋白）的相互作用，從而抑制下游信號通路（如MAPK、PI3K/AKT）的激活，為靶向治療提供潛在策略。目前，相關(guān)研究聚焦于評估DDR1靶向藥物在實(shí)體瘤中的抗腫瘤活性，尤其在克服腫瘤微環(huán)境纖維化導(dǎo)致的治療抵抗方面展現(xiàn)出潛力，部分臨床試驗(yàn)已進(jìn)入早期階段，探索其單藥或聯(lián)合用藥的安全性與有效性。 該抗體廣泛應(yīng)用于DDR1功能機(jī)制研究，包括實(shí)驗(yàn)，用于檢測細(xì)胞或組織樣本中DDR1的表達(dá)水平與定位。通過特異性識別DDR1不同亞型（如DDR1a），研究者可深入解析其在細(xì)胞分化、器官纖維化（如腎纖維化、肺纖維化）及炎癥反應(yīng)中的作用機(jī)制。此外，作為工具抗體，其高特異性和親和力有助于構(gòu)建DDR1基因敲除/敲入模型的驗(yàn)證體系，推動(dòng)DDR1相關(guān)疾病靶點(diǎn)的發(fā)現(xiàn)與藥物研發(fā)進(jìn)程。 綜上，DDR1重組單克隆抗體不僅為DDR1介導(dǎo)疾病的臨床治療提供了新方向，也為基礎(chǔ)科研中受體酪氨酸激酶信號網(wǎng)絡(luò)的解析奠定了重要工具基礎(chǔ)，具有顯著的轉(zhuǎn)化醫(yī)學(xué)價(jià)值。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CAK antibody; CD 167 antibody; CD167 antibody; CD167 antigen-like family member A antibody; CD167a antibody; Cell adhesion kinase antibody; DDR 1 antibody; DDR antibody; DDR1 antibody; DDR1_HUMAN antibody; Discoidin domain receptor antibody; Discoidin domain receptor tyrosine kinase 1 antibody; Discoidin receptor tyrosine kinase antibody; Discoidin receptor tyrosine kinase isoform a antibody; EDDR 1 antibody; EDDR1 antibody; Epithelial discoidin domain receptor 1 antibody; Epithelial discoidin domain-containing receptor 1 antibody; Epithelial specific receptor kinase antibody; HGK2 antibody; Mammarian carcinoma kinase 10 antibody; Mammary carcinoma kinase 10 antibody; MCK-10 antibody; MCK10 antibody; NEP antibody; Neuroepithelial tyrosine kinase antibody; Neurotrophic tyrosine kinase receptor type 4 antibody; NTRK 4 antibody; NTRK4 antibody; OTTHUMP00000029343 antibody; OTTHUMP00000029344 antibody; OTTHUMP00000029345 antibody; OTTHUMP00000029346 antibody; OTTHUMP00000029347 antibody; OTTHUMP00000164863 antibody; OTTHUMP00000164867 antibody; OTTHUMP00000222080 antibody; Protein-tyrosine kinase 3A antibody; Protein-tyrosine kinase RTK-6 antibody; PTK 3 antibody; PTK 3A protein tyrosine kinase 3A antibody; PTK3 antibody; PTK3A antibody; Receptor tyrosine kinase NEP antibody; RTK 6 antibody; RTK6 antibody; TRK E antibody; TRKE antibody; Tyrosine kinase DDR antibody; Tyrosine kinase receptor E antibody; Tyrosine-protein kinase CAK antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human DDR1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
  • 基因功能參考文獻(xiàn)：
    1. Data (including data from studies using knockout mice) suggest that DDR1 plays role in promoting mammary tumor growth; tumor-extrinsic DDR1 appears to be required for promotion of mammary tumors by interleukin-6. PMID: 29298894
    2. our study provides a novel regulatory pathway involving TM4SF1, DDR1, MMP2 and MMP9, which promotes the formation and function of invadopodia to support cell migration and invasion in pancreatic cancer. PMID: 28368050
    3. The three well-conserved seed matched sites for miR-199a/b-5p in the discoidin domain receptor 1 (DDR1) 3'-UTR were targeted, and miRNA binding to at least two sites was required for DDR1 inhibition. PMID: 29429150
    4. E2F1 knockdown decreased the expression of discoidin domain receptor 1 (DDR1) which plays a crucial role in many fundamental processes such as cell differentiation, adhesion, migration and invasion. PMID: 29039472
    5. Furthermore, the inhibition of DDR1 with 7rh showed striking efficacy in combination with chemotherapy in orthotopic xenografts and autochthonous pancreatic tumors where it significantly reduced DDR1 activation and downstream signaling, reduced primary tumor burden, and improved chemoresponse. PMID: 28864681
    6. These findings demonstrate a critical role of miR-199a-3p/DDR1 pathway in ovarian cancer development. PMID: 28743276
    7. findings demonstrate that, in human breast cancer cells, DDR1 regulates IR expression and ligand dependent biological actions. This novel functional crosstalk is likely clinically relevant PMID: 28591735
    8. These results support an activation mechanism of DDR1 whereby collagen induces lateral association of DDR1 dimers and phosphorylation between dimers. PMID: 28590245
    9. Data suggest that IGF-I/IGF-IR system triggers stimulatory actions through both GPER and DDR1 in aggressive tumors as mesothelioma and lung tumors. PMID: 27384677
    10. we further analyzed the CpG methylation levels at the DDR1 promoter in EOC cells and found that the CpG methylation levels of DDR1 promoter correlated negatively with the expression of DDR1 along the EMT spectrum. Therefore, EMT stratification could be a potential biomarker to predict patient response to DDR1-targeting drugs. PMID: 28887161
    11. This study suggested that DDR1 and DDR2 knockdown alters brain immunity and significantly reduces the level of triggering receptor expressed on myeloid cells (TREM)-2 and microglia. PMID: 28863860
    12. Isoform b of DDR1 is responsible for collagen I-induced up-regulation of N-cadherin and tyrosine 513 of DDR1b is necessary. PMID: 27605668
    13. Reduced DDR1 expression may be implicated in impaired melanocyte adhesion process involved in vitiligo pathogenesis PMID: 26091274
    14. data demonstrate that TGF-beta1 favors linear invadosome formation through the expressions of both the inducers, such as collagen and LOXL2, and the components such as DDR1 and MT1-MMP of linear invadosomes in cancer cells. Meanwhile, our data uncover a new TGF-beta1-dependent regulation of DDR1 expression. PMID: 27720259
    15. DDR1 overexpression promoted GC cell proliferation (p < 0.05), migration (p < 0.01), and invasion (p < 0.01), and accelerated the growth (p < 0.05) as well as the microvessel formation (p < 0.01) of transplantation tumor in nude mice. PMID: 27179963
    16. Our results suggest that DDR1 is both a prognostic marker for renal clear cell carcinoma and a potential functional target for therapy PMID: 27020590
    17. Study concludes that non-canonical DDR1 signaling enables breast cancer cells to exploit the ubiquitous interstitial matrix component collagen I to undergo metastatic reactivation in multiple target organs. PMID: 27368100
    18. Upregulation of DDR1 collagen receptor is associated with breast cancer. PMID: 26655502
    19. Knockdown DDR1 reversed the effects of Galpha13 knockdown on cell-cell adhesion and proteolytic invasion in three-dimensional collagen. PMID: 26589794
    20. Data suggest SCl2 (Streptococcus pyogenes) binds to DDR (DDR1, DDR2) ectodomain w/o stimulating receptor signaling; here, protein engineering was used to construct SCl-like proteins that inhibit collagen-DDR interactions and macrophage migration. PMID: 26702058
    21. DDR1 is a key modulator of RIT activity. PMID: 26719540
    22. DDR1 expression is a prognostic indicator in pancreatic ductal carcinoma. PMID: 26297342
    23. alpha5(IV), but not alpha1(IV), promotes lung cancer cell proliferation and tumor angiogenesis through non-integrin collagen receptor DDR1-mediated ERK activation. PMID: 25992553
    24. Hypoxia can increase DDR1 expression in pituitary adenoma cells, leading to improved MMP-2 and MMP-9 secretion, and promoting pituitary adenoma cell proliferation and invasion. PMID: 26286316
    25. suggest that DDR1 suppression may enhance adipose-derived stem cell chondrogenesis by enhancing the expression of chondrogenic genes and cartilaginous matrix deposition. PMID: 25673773
    26. MT1-MMP-discoidin domain receptor 1 axis regulates collagen-induced apoptosis in breast cancer cells PMID: 25774665
    27. Defective Ca(2+) binding in a conserved binding site causes incomplete N-glycan processing and endoplasmic reticulum trapping of DDR1 and DDR2 receptors. PMID: 25470979
    28. A DDR1(Low)/DDR2(High) protein profile is associated with TNBC and may identify invasive carcinomas with worse prognosis. PMID: 25667101
    29. We uncovered ten new mutations in TNK2 and DDR1 within serous and endometrioid ECs, thus providing novel insights into the mutation spectrum of each gene in EC. PMID: 25427824
    30. Silencing of DDR1 inhibited tumor cell growth and motility, and induced TGFBI expression, both in vitro and in vivo. PMID: 25369402
    31. found an inverse correlation between ZEB1 and DDR1 expression in various cancer cell lines and in human breast carcinoma tissues PMID: 25155634
    32. DDR1 depletion blocked cell invasion in a collagen gel PMID: 25422375
    33. The expression of the DDR1 protein significantly correlated with poor disease-free survival in patients with serous ovarian cancer. PMID: 21541037
    34. High DDR1 protein expression is associated with recurrence in ameloblastomas. PMID: 24723326
    35. In this review we highlight the mechanisms whereby DDRs(DDR1 and DDR2) regulate two important processes, namely inflammation and tissue fibrosis. PMID: 24361528
    36. Report aberrant methylation of DDR1 in men with nonobstructive azoospermia. PMID: 25064398
    37. Crystal structures of DDR1 reveal a DFG-out conformation (DFG, Asp-Phe-Gly) of the kinase domain that is stabilized by a salt bridge between the activation loop and alphaD helix. Differences to Abelson kinase are observed in the DDR1 P-loop's beta-hairpin. PMID: 24768818
    38. These findings indicate that the extracellular juxtamembrane region of DDR1 is exceptionally flexible and does not constrain the basal or ligand-activated state of the receptor. PMID: 24671415
    39. N-glycosylation at the highly conserved (211)NDS motif evolved to act as a negative repressor of DDR1 phosphorylation in the absence of ligand PMID: 24509848
    40. regulation of DDRs by glucose PMID: 24018687
    41. Upregulation of DDR1 induced by collagen I may contribute to the development and progression of NSCLC. PMID: 23761027
    42. The DDR1 extracellular domain plays a crucial role in receptor oligomerization which mediates high-affinity interactions with its ligand. PMID: 23810922
    43. We show that expression of the latent LMP1 in primary human germinal center B cells, the presumed progenitors of HRS cells, upregulates discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase activated by collagen. PMID: 24136166
    44. these data suggest that NEP can augment taxane-induced apoptosis through inhibition of Akt/Bad signaling PMID: 22895534
    45. the expression of the novel collagen receptor discoidin domain receptor 1 (DDR1) by human MKs at both mRNA and protein levels and provide evidence of DDR1 involvement in the regulation of MK motility on type I collagen PMID: 23530036
    46. DDR1 expression was not predictive for patient survival in human breast cancer PMID: 23307244
    47. DD1 mRNA and protein levels were higher in patients with recurrent Hepatocellular carcinoma , suggesting this gene maybe involved in tumor invasion and metastasis. PMID: 22752569
    48. a role for the collagenase of membrane-type MMPs in regulation of DDR1 cleavage and activation at the cell-matrix interface. PMID: 23519472
    49. Discoidin domain receptors promote alpha1beta1- and alpha2beta1-integrin mediated cell adhesion to collagen by enhancing integrin activation. PMID: 23284937
    50. Discoidin domain receptors are unique receptor tyrosine kinases in collagen-mediated signaling [review] PMID: 23335507

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  • 亞細(xì)胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.; [Isoform 4]: Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
  • 組織特異性：
    Detected in T-47D, MDA-MB-175 and HBL-100 breast carcinoma cells, A-431 epidermoid carcinoma cells, SW48 and SNU-C2B colon carcinoma cells and Hs 294T melanoma cells (at protein level). Expressed at low levels in most adult tissues and is highest in the b
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2730

    OMIM: 600408

    KEGG: hsa:780

    STRING: 9606.ENSP00000365759

    UniGene: Hs.631988



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