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  4. CSF2RB (trabikibart Biosimilar) Recombinant Monoclonal Antibody

CSF2RB (trabikibart Biosimilar) Recombinant Monoclonal Antibody

  • 貨號：
    CSB-RA006047MB2HU
  • 規(guī)格：
    ￥83486
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSF2RB（trabikibart Biosimilar Antibody）重組單克隆抗體是一種針對人類CSF2RB蛋白，其靶點為細胞因子受體共同β鏈（CD131），該蛋白是GM-CSF、IL-3和IL-5受體的關鍵亞基，在免疫調(diào)節(jié)和造血過程中發(fā)揮重要作用。該抗體的來源于重組人CSF2RB蛋白，具有高度的種屬特異性，僅對人類樣本表現(xiàn)出反應性。其別名包括Beta-C抗體、CD131抗體、GM-CSF/IL-3/IL-5受體共同β鏈抗體等，反映了其靶點的多種生物學命名及功能關聯(lián)。 trabikibart Biosimilar Antibody作為靶向CSF2RB抗體，trabikibart類似物，被探索用于治療哮喘、慢性阻塞性肺疾?。–OPD）等過敏性和炎癥性疾病，通過阻斷GM-CSF/IL-3/IL-5介導的信號傳導，減輕嗜酸性粒細胞浸潤和炎癥反應。此外，其在造血干細胞增殖調(diào)控中的作用也為再生障礙性貧血等血液疾病的治療提供了潛在方向。目前，相關藥物的研發(fā)聚焦于提高靶向性和降低毒性，以優(yōu)化臨床療效和安全性。 CSF2RB重組單克隆抗體主要用于實驗，助力解析CSF2RB在免疫細胞分化、細胞因子信號轉(zhuǎn)導中的分子機制。研究人員通過該抗體可特異性檢測CSF2RB在不同組織和細胞中的表達水平，為探討其在腫瘤微環(huán)境調(diào)節(jié)、自身免疫病發(fā)病機制中的作用提供工具。其種屬反應性限定為人類，提示實驗需使用人源細胞或組織樣本，確保研究結果的準確性和特異性。 綜上，CSF2RB重組單克隆抗體不僅是炎癥性疾病和血液疾病臨床治療的潛在候選藥物，也是深入研究細胞因子受體功能及相關疾病機制的重要科研工具，具有重要的轉(zhuǎn)化醫(yī)學價值。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Beta-C antibody; CD131 antibody; CDw131 antibody; Colony stimulating factor 2 receptor beta antibody; Colony stimulating factor 2 receptor beta low affinity；granulocyte macrophage antibody; Common beta chain antibody; Csf2rb antibody; Cytokine receptor common beta chain antibody; Cytokine receptor common beta chain precursor；CDw131 antigen antibody; Cytokine receptor common subunit beta antibody; GM CSF/IL 3/IL 5 receptor common beta chain antibody; GM-CSF/IL-3/IL-5 receptor common beta subunit antibody; granulocyte-macrophage colony-stimulating factor receptor, beta antibody; IL3RB antibody; IL3RB_HUMAN antibody; IL5RB antibody; Interleukin 3 receptor, beta antibody; Interleukin 3 receptor/granulocyte macrophage colony stimulating factor 3 receptor beta；high affinity antibody; Interleukin 5 receptor, beta antibody; SMDP5 antibody; stimulating factor 3 receptor, beta；high affinity antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human CSF2RB protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    0.01M PBS，pH7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應用說明：
    Validation Status
    Application-specific performance (e.g., in flow cytometry, ELISA, IHC or other assay formats) has not yet been experimentally verified by CUSABIO. Users are advised to determine the optimal working conditions empirically in their own assay systems.
    Guaranteed Quality
    ① Antibody purity?> 95% tested by SDS-PAGE.
    ② Endotoxin level < 0.1EU/ug tested by LAL method.
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    In stock
  • 用途：
    It is a non-therapeutic biosimilar antibody, owning the same variable region from the corresponding approved therapeutic antibody. In conclusion, it is a research-grade biosimilar antibody and expressed in mammalian cell, which can be directly used as positive controls in drug discovery or used for rapid verification of the biological functions of target protein.

產(chǎn)品評價

靶點詳情

  • 功能：
    High affinity receptor for interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor.
  • 基因功能參考文獻：
    1. SYK mediates the actions of EPO and GM-CSF and coordinates with TGF-beta in erythropoiesis. PMID: 28131718
    2. Exome sequencing identified candidate variants, including a missense mutation in DUOX2 that impaired its function and a frameshift mutation in CSF2RB that was associated with Crohn's Disease in an independent cohort of Ashkenazi Jewish individuals. PMID: 27373512
    3. In a genetic analysis of Ashkenazi Jewish individuals, we associated Crohn's Disease with a frameshift mutation in CSF2RB. Intestinal monocytes from carriers of this mutation had reduced responses to granulocyte-macrophage colony-stimulating factor, providing an additional mechanism for alterations to the innate immune response in individuals with Crohn's Disease. PMID: 27377463
    4. VitD-mediated stimulation of GC anti-inflammatory affects human monocytes in a process involving GM-CSF and MED14 PMID: 23572530
    5. These data suggest that expression of GM-CSF and its receptor subunits by colon tumors may be a useful marker for prognosis PMID: 23108143
    6. JAK kinase binding to betac requires the presence of three critical betac lysine residues, and this binding event is essential for receptor ubiquitination, endocytosis, and signaling. PMID: 21965659
    7. Over expression of IL-3Ralpha and truncated mutation of hbetac may be involved in proliferation and differentiation block in NB4 cells. PMID: 21176354
    8. Granulocyte/macrophage colony-stimulating factor causes a paradoxical increase in the BH3-only pro-apoptotic protein Bim in human neutrophils PMID: 20705940
    9. The results of the study support CSF2RB as a risk factor common to both schizophrenia and major depression in the Chinese Han population. PMID: 21247258
    10. Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations [case report] PMID: 21205713
    11. the up-regulation of IL-3Rbeta expression may contribute to the maintenance of proliferation rather than cell differentiation. PMID: 21207215
    12. The beta1 integrin-interacting domain in the extracellular domain of IL-3Rbeta was identified. A fragment of a protein corresponding to domain 4 of IL-3Rbeta prevented IL-3-mediated arterial morphogenesis and endothelial cell migration. PMID: 20802515
    13. the domain 1 D-E loop disulfide of hbetac and beta(IL-3) have roles in maintaining the precise positions of ligand-binding residues necessary for normal high affinity binding and signaling PMID: 20516062
    14. Two different modes of beta c binding are utilized in the presence of the hIL-3R alpha isoforms. PMID: 20472554
    15. hGM-CSF activation of hGM/beta(c)with or w/o the hbeta(c) subunit, promoted primitive phenotype maintenance, indicating that the hGM Ralpha chain cytosolic domain is needed for differentiation mediated by the hGM Ralpha, beta(c) receptor complex. PMID: 12384414
    16. JAK2 activation mediates cross-talk between extracellular domain mutants of the beta-subunit of the GM-CSF receptor and EpoR PMID: 12488507
    17. Interleukin-3 binding to the human betac receptor involves functional epitopes formed by domains 1 and 4 of different protein chains PMID: 15060062
    18. A minor improvement in resolution has given a clearer indication of the position and stabilization of the key residues Tyr15, Phe79, Tyr347, His349, Ile350 and Tyr403 in the elbow region between domain 1 and domain 4 of the dimer-related molecule. PMID: 16754968
    19. These results suggest that the JAK1-JH7-3 domains are required for interleukin-3 receptor common beta subunit interaction and abolish wild type JAK1 and JAK2-mediated signaling. PMID: 16767694
    20. This study found that several markers (rs2072707, rs2284031 and rs909486)of csf2rb showed sex-specific and family history-dependent associations with schizophrenia. PMID: 17667962
    21. The dynamic role of the common signaling subunit beta c is to prevent IL5alpha and GM-CSF ligand-receptor complexes from rapidly dissociating. PMID: 18294864
    22. The interaction between intercellular adhesion molecule 1 (ICAM-1) and the GM-CSF receptor is essential for GM-CSF-induced eosinophil activation and survival. PMID: 18322230
    23. IL-5-induced effects on betac assembly in the presence of nontagged IL-5Ralpha provide direct evidence that IL-5 can cause higher order rearrangements of betac homo-oligomers PMID: 18326494
    24. Ligand-binding and receptor activation are not critically dependent on individual N-glycosylation sites within the IL-3- and IL-5-receptor common beta-subunit. PMID: 18374598

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  • 相關疾?。?/div>
    Pulmonary surfactant metabolism dysfunction 5 (SMDP5)
  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Type I cytokine receptor family, Type 4 subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2436

    OMIM: 138981

    KEGG: hsa:1439

    STRING: 9606.ENSP00000384053

    UniGene: Hs.592192



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